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9.3 CELL CYCLE REGULATION  WHAT YOU WILL LEARN -How cancer relates to the cell cycle -The role of apoptosis -Types / Uses of stem cells.

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Presentation on theme: "9.3 CELL CYCLE REGULATION  WHAT YOU WILL LEARN -How cancer relates to the cell cycle -The role of apoptosis -Types / Uses of stem cells."— Presentation transcript:

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2 9.3 CELL CYCLE REGULATION  WHAT YOU WILL LEARN -How cancer relates to the cell cycle -The role of apoptosis -Types / Uses of stem cells

3 READING Q’s NAME -When are some of the important combinations active? -mitosis and interphase (G 1, S, G 2 )

4 READING Q’s DEFINE -What is cancer? -the uncontrolled growth and division of cells

5 READING Q’s IDENTIFY -What is an example of a carcinogen that occurs in nature? -ultraviolet radiation from the SUN

6 READING Q’s IDENTIFY -Which statement about apoptosis is correct? A- Apoptosis can lead to cancer. B- Apoptosis can prevent cancer.

7 READING Q’s DESCRIBE -What are stem cells? -unspecialized cells that can develop into a variety of specialized cells Bill Nye Greatest Discoveries—CELL DIVISION

8 GROUP WORK: APPLICATION NOTES -As a group complete the application notes using your knowledge from the reading.

9 9.3 MAIN IDEA  Normal cell cycle is regulated by cyclin proteins

10 9.3 CELL CYCLE REGULATION  WHAT YOU WILL LEARN -How cancer relates to the cell cycle -The role of apoptosis -Types / Uses of stem cells

11 READING Q’s DEFINE -What is cancer? -the uncontrolled growth and division of cells  NORMAL CELL CYCLE

12 SUMMARIZE: How cells regulate the cell cycle. -Cells use _______________ and _______________ to control the cell cycle. -Different combinations of _______________ start the cell cycle at different _______________. -The cell also uses _______________ to monitor the cycle for quality control. - In _______________, the cell checks the DNA for damage. If there is any damage, the cycle won’t proceed to _______________. -In _______________, the spindle fibers are malfunctioning, the cycle won’t proceed to ___________. CDK- Cyclin dependent kinases mitosis G 1 stage S stage cytokinesis cyclins cyclin/CDK checkpoints cyclin/CDK

13  CANCER CELL CYCLE SEQUENCE: The cause/effects of cancer A failure in regulation of cell cycle uncontrolled growth/division of cells cancer cells go unchecked crowding out normal cells--leading to tissue/organ failure

14 SUMMARIZE

15  ABNORMAL CELL CYCLE IDENTIFY: Four environmental factors that cause cancer. 1-__________________________ 2-__________________________ 3-__________________________ 4-__________________________ Unregulated cancer cell growth CIGARETTE SMOKE/TOBACCO ASBESTOS X RAYS ULTRAVIOLET RADIATION

16  APOPTOSIS SUMMARIZE: Information about apoptosis- APOPTOSIS IS- -process of programmed cell death Organisms use apoptosis to- -destroy cells that are no longer needed -destroy cells damaged beyond repair Processes that use apoptosis (examples)- 1-trees losing their leaves in autumn 2-development of hands and feet in embryo

17 READING Q’s IDENTIFY -Which statement about apoptosis is correct? A- Apoptosis can lead to cancer. B- Apoptosis can prevent cancer.  APOPTOSIS

18 READING Q’s  APOPTOSIS

19 READING Q’s 1-”triggers” in body send signals for cell death [viruses/free radicals/stress/radiation] 2-capsases [proteins]: -break down cell components -produce DNases—destroys DNA in nucleus 3-cell shrinks and sends “distress” signals 4-macrophages ingest/clean away shrunken cells  APOPTOSIS

20  STEM CELLS LIST: Write three facts you discovered about stem cells 1-unspecialized cells that can develop into a variety of specialized cells 2- 2 types: adult & embryonic 3- can be directed to a specific type of cell Bill Nye Greatest Discoveries—CELL DIVISION

21  STEM CELLS COMPARE/CONTRAST: Adult and embryonic stem cells -comes from various tissues in body -present from infancy thru adulthood -unspecialized cells that have potential to become specialized cells formed after fertilization -become specialized as embryo grows

22 SUMMARIZE COMPLETE: A=apoptosisS=stem cells ___ 1-After a sperm fertilizes an egg, the resulting mass of cells divides until there are about cells. ___ 2-Some cells go through a programmed death. ___ 3-Embryonic cells shrivel and die, resulting in the formation of fingers and toes. ___ 4-Unspecialized cells are either embryonic or adult. ___ 5. This event occurs in cells that are damaged beyond repair. S A A S A

23 SUMMARIZE EXPLAIN: How cancerous cell growth differs from normal cell growth -The cancer cell cycle is much faster than the normal cycle. -interphase is dramatically shorter in cancer cells NORM stomach cellsCANCER stomach cells Interphase120 min16 min Prophase60 min15 min Metaphase10 min2 min Ananphase3 min1 min Telophase12 min3 min

24 CANCER DRUGS OVERVIEW: -damage DNA work in all phases of cell cycle -interfere w/DNA & RNA growth by replacing building blocks destroy cell in S phase -interfere w/enzymes involved in DNA replication work in all phases of cell cycle -inhibit enzymes needed to make proteins in cell cycle work during MITOSIS, can damage cells at all stages

25 ILLUSTRATE


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