Presentation on theme: "WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION"— Presentation transcript:
1WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION -How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells
2READING Q’s NAME -When are some of the important combinations active? -mitosis and interphase (G1, S, G2)
3DEFINE -What is cancer? -the uncontrolled growth and division of cells READING Q’sDEFINE-What is cancer?-the uncontrolled growth and division of cells
4READING Q’sIDENTIFY-What is an example of a carcinogen that occurs in nature?-ultraviolet radiation from the SUN
5READING Q’s IDENTIFY -Which statement about apoptosis is correct? A- Apoptosis can lead to cancer.B- Apoptosis can prevent cancer.
6READING Q’s DESCRIBE -What are stem cells? -unspecialized cells that can develop into a variety of specialized cellsBill Nye Greatest Discoveries—CELL DIVISION
7GROUP WORK: APPLICATION NOTES -As a group complete the application notes using your knowledge from the reading.
8Normal cell cycle is regulated by cyclin proteins 9.3 MAIN IDEANormal cell cycle is regulated by cyclin proteins
9WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION -How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells
10DEFINE -What is cancer? -the uncontrolled growth and division of cells READING Q’sNORMAL CELL CYCLEDEFINE-What is cancer?-the uncontrolled growth and division of cells
11NORMAL CELL CYCLE cyclins cyclin/CDK checkpoints cyclin/CDK G1 stage SUMMARIZE: How cells regulate the cell cycle.-Cells use _______________ and _______________ to control the cell cycle.-Different combinations of _______________ start the cell cycle at different _______________.-The cell also uses _______________ to monitor the cycle for quality control.-In _______________, the cell checks the DNA for damage. If there is any damage, the cycle won’t proceed to _______________.-In _______________, the spindle fibers are malfunctioning, the cycle won’t proceed to ___________.cyclinsCDK-Cyclin dependent kinasescyclin/CDKcheckpointscyclin/CDKG1 stageS stagemitosiscytokinesis
12SEQUENCE: The cause/effects of cancer CANCER CELL CYCLESEQUENCE:The cause/effects of canceruncontrolled growth/division of cellsA failure in regulation of cell cyclecancer cells go uncheckedcrowding out normal cells--leading to tissue/organ failure
14ABNORMAL CELL CYCLE IDENTIFY: Four environmental factors that cause cancer.1-__________________________2-__________________________3-__________________________4-__________________________Unregulated cancer cell growthASBESTOSCIGARETTE SMOKE/TOBACCOX RAYSULTRAVIOLET RADIATION
15APOPTOSIS SUMMARIZE: Information about apoptosis- APOPTOSIS IS- -process of programmed cell deathOrganisms use apoptosis to--destroy cells that are no longer needed-destroy cells damaged beyond repairProcesses that use apoptosis (examples)-1-trees losing their leaves in autumn2-development of hands and feet in embryo
16APOPTOSIS READING Q’s IDENTIFY -Which statement about apoptosis is correct?A- Apoptosis can lead to cancer.B- Apoptosis can prevent cancer.
18APOPTOSIS READING Q’s 1-”triggers” in body send signals for cell death[viruses/free radicals/stress/radiation]2-capsases [proteins]:-break down cell components-produce DNases—destroys DNA in nucleus3-cell shrinks and sends “distress” signals4-macrophages ingest/clean away shrunken cells
19STEM CELLS LIST: Write three facts you discovered about stem cells 1-unspecialized cells that can develop into a variety of specialized cells2- 2 types: adult & embryonic3- can be directed to a specific type of cellBill Nye Greatest Discoveries—CELL DIVISION
20COMPARE/CONTRAST: Adult and embryonic stem cells -comes from various tissues in body-present frominfancy thru adulthood-unspecialized cells that have potential to become specializedcells formed after fertilization-become specialized as embryo grows
21S A A S A SUMMARIZE COMPLETE: A=apoptosis S=stem cells ___ 1-After a sperm fertilizes an egg, the resulting mass of cellsdivides until there are about cells.___ 2-Some cells go through a programmed death.___ 3-Embryonic cells shrivel and die, resulting in the formationof fingers and toes.___ 4-Unspecialized cells are either embryonic or adult.___ 5. This event occurs in cells that are damaged beyond repair.SAASA
22SUMMARIZEEXPLAIN:How cancerous cell growth differs from normal cell growth-The cancer cell cycle is much faster than the normal cycle.-interphase is dramatically shorter in cancer cellsNORM stomach cells CANCER stomach cellsInterphase 120 min 16 minProphase 60 min 15 minMetaphase 10 min 2 minAnanphase 3 min 1 minTelophase 12 min 3 min
23CANCER DRUGS OVERVIEW: -damage DNA work in all phases of cell cycle -interfere w/DNA & RNA growth by replacing building blocksdestroy cell in S phase-interfere w/enzymes involved in DNA replication-inhibit enzymes needed to make proteins in cell cyclework during MITOSIS, can damage cells at all stages