Presentation on theme: "WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION"— Presentation transcript:
1 WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION -How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells
2 READING Q’s NAME -When are some of the important combinations active? -mitosis and interphase (G1, S, G2)
3 DEFINE -What is cancer? -the uncontrolled growth and division of cells READING Q’sDEFINE-What is cancer?-the uncontrolled growth and division of cells
4 READING Q’sIDENTIFY-What is an example of a carcinogen that occurs in nature?-ultraviolet radiation from the SUN
5 READING Q’s IDENTIFY -Which statement about apoptosis is correct? A- Apoptosis can lead to cancer.B- Apoptosis can prevent cancer.
6 READING Q’s DESCRIBE -What are stem cells? -unspecialized cells that can develop into a variety of specialized cellsBill Nye Greatest Discoveries—CELL DIVISION
7 GROUP WORK: APPLICATION NOTES -As a group complete the application notes using your knowledge from the reading.
8 Normal cell cycle is regulated by cyclin proteins 9.3 MAIN IDEANormal cell cycle is regulated by cyclin proteins
9 WHAT YOU WILL LEARN 9.3 CELL CYCLE REGULATION -How cancer relates to the cell cycle-The role of apoptosis-Types / Uses of stem cells
10 DEFINE -What is cancer? -the uncontrolled growth and division of cells READING Q’sNORMAL CELL CYCLEDEFINE-What is cancer?-the uncontrolled growth and division of cells
11 NORMAL CELL CYCLE cyclins cyclin/CDK checkpoints cyclin/CDK G1 stage SUMMARIZE: How cells regulate the cell cycle.-Cells use _______________ and _______________ to control the cell cycle.-Different combinations of _______________ start the cell cycle at different _______________.-The cell also uses _______________ to monitor the cycle for quality control.-In _______________, the cell checks the DNA for damage. If there is any damage, the cycle won’t proceed to _______________.-In _______________, the spindle fibers are malfunctioning, the cycle won’t proceed to ___________.cyclinsCDK-Cyclin dependent kinasescyclin/CDKcheckpointscyclin/CDKG1 stageS stagemitosiscytokinesis
12 SEQUENCE: The cause/effects of cancer CANCER CELL CYCLESEQUENCE:The cause/effects of canceruncontrolled growth/division of cellsA failure in regulation of cell cyclecancer cells go uncheckedcrowding out normal cells--leading to tissue/organ failure
14 ABNORMAL CELL CYCLE IDENTIFY: Four environmental factors that cause cancer.1-__________________________2-__________________________3-__________________________4-__________________________Unregulated cancer cell growthASBESTOSCIGARETTE SMOKE/TOBACCOX RAYSULTRAVIOLET RADIATION
15 APOPTOSIS SUMMARIZE: Information about apoptosis- APOPTOSIS IS- -process of programmed cell deathOrganisms use apoptosis to--destroy cells that are no longer needed-destroy cells damaged beyond repairProcesses that use apoptosis (examples)-1-trees losing their leaves in autumn2-development of hands and feet in embryo
16 APOPTOSIS READING Q’s IDENTIFY -Which statement about apoptosis is correct?A- Apoptosis can lead to cancer.B- Apoptosis can prevent cancer.
18 APOPTOSIS READING Q’s 1-”triggers” in body send signals for cell death[viruses/free radicals/stress/radiation]2-capsases [proteins]:-break down cell components-produce DNases—destroys DNA in nucleus3-cell shrinks and sends “distress” signals4-macrophages ingest/clean away shrunken cells
19 STEM CELLS LIST: Write three facts you discovered about stem cells 1-unspecialized cells that can develop into a variety of specialized cells2- 2 types: adult & embryonic3- can be directed to a specific type of cellBill Nye Greatest Discoveries—CELL DIVISION
20 COMPARE/CONTRAST: Adult and embryonic stem cells -comes from various tissues in body-present frominfancy thru adulthood-unspecialized cells that have potential to become specializedcells formed after fertilization-become specialized as embryo grows
21 S A A S A SUMMARIZE COMPLETE: A=apoptosis S=stem cells ___ 1-After a sperm fertilizes an egg, the resulting mass of cellsdivides until there are about cells.___ 2-Some cells go through a programmed death.___ 3-Embryonic cells shrivel and die, resulting in the formationof fingers and toes.___ 4-Unspecialized cells are either embryonic or adult.___ 5. This event occurs in cells that are damaged beyond repair.SAASA
22 SUMMARIZEEXPLAIN:How cancerous cell growth differs from normal cell growth-The cancer cell cycle is much faster than the normal cycle.-interphase is dramatically shorter in cancer cellsNORM stomach cells CANCER stomach cellsInterphase 120 min 16 minProphase 60 min 15 minMetaphase 10 min 2 minAnanphase 3 min 1 minTelophase 12 min 3 min
23 CANCER DRUGS OVERVIEW: -damage DNA work in all phases of cell cycle -interfere w/DNA & RNA growth by replacing building blocksdestroy cell in S phase-interfere w/enzymes involved in DNA replication-inhibit enzymes needed to make proteins in cell cyclework during MITOSIS, can damage cells at all stages