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John E. Lewis, Ph.D. Associate Professor University of Miami Miller School of Medicine Department of Psychiatry & Behavioral Sciences 1120 NW 14th Street.

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Presentation on theme: "John E. Lewis, Ph.D. Associate Professor University of Miami Miller School of Medicine Department of Psychiatry & Behavioral Sciences 1120 NW 14th Street."— Presentation transcript:

1 John E. Lewis, Ph.D. Associate Professor University of Miami Miller School of Medicine Department of Psychiatry & Behavioral Sciences 1120 NW 14th Street Suite #1474 (D28) Phone: 305-243-6227 Fax: 305-243-1619 E-mail: Optimizing Your Health through Proper Nutrition and Exercise

2 What are we doing? We have the following ongoing studies: 1.Aerobic and strengthening exercise training and nutrition education on metabolic syndrome variables in HIV 2.Vitamin D on nutrient status, QOL, and bone mineral density in the elderly 3.A broad-spectrum nutrient supplement on oxidative stress, inflammation, immune functioning, and telomeres and telomerase in healthy adults 4.Magnesium sulfate infusion in treatment-resistant depression

3 5.Low-level class IV laser therapy on peripheral neuropathy in type 2 diabetes 6.A polysaccharide (rice bran and Shiitake mushroom) on immunological functioning and metabolic syndrome in HIV 7.Assessment of HbA1c and blood pressure with bioelectrical impedance in healthy adults and in persons with type 2 diabetes What are we doing?


5 “All parts of the body which have a function, if used in moderation and exercised in labours in which each is accustomed, become thereby healthy, well-developed, and age more slowly, but if unused and left idle they become quickly liable to disease, defective in growth, and age more quickly.” Hippocrates also said (450 BC)…













18 Why do we have large numbers (epidemics!) of people with: Obesity Cardiovascular disease Type 2 diabetes Cancer Osteoporosis Arthritis Mental health disorders like depression Chronic pain

19 Trends in Prevalence of Obesity United States, 1960-2004 Ogden, C., Carroll, M., Curtin, L., McDowell, M., Tabak, C., and Flegal, K. (2006). Prevalence of overweight and obesity in the United States, 1999-2004. JAMA, 295, 1549- 1555.



22 Obesity in the future...

23 1. Physical inactivity 2. Poor nutrition What causes chronic disease and excess fat? U.S. Department of Health and Human Services and U.S. Department of Agriculture. (2005). Dietary Guidelines for Americans, 2005. 6th ed. Washington, DC: U.S. Government Printing Office.


25 So what can you do to prevent chronic disease and optimize your health? The answer lies in a very simple approach to your dietary and physical activity behaviors.

26 1. Eat foods as close to the way they appear in their natural state (i.e., either in the ground or on a tree). 2. Eat a predominantly whole-food, plant-based diet. 3. If you follow the first two maxims, then do NOT count calories. It’s a waste of time. For your nutrition, remember a few very simple maxims...

27 Organic versus Conventional?

28 Greens have plenty of protein! Selected nutrients in a 100-calorie portion of four foods: BroccoliRomaineKaleSirloin Lettuce Protein11.2 g11.6 g9.5 g5.4 g Calcium182 mg257 mg455 mg2.4 mg Magnesium71.4 mg43 mg59 mg5 mg Iron2.2 mg7.9 mg3.1 mg.7 mg Fiber10.7 g12 g6.7 g0 Vitamin C143 mg171 mg83 mg0 Cholesterol00055 mg Saturated Fat0001.7 g Weight357 g714 g333 g24 g Adams, C. (1986). Handbook of the nutritional value of foods in common units. New York: Dover Publications.

29 Don’t you need to consume cow’s milk to get calcium and protein?

30 Dairy industry revenue for 2013 was $38,000,000,000! Reference:

31 You drink her milk…

32 But would you drink their milk?

33 1.Cardiovascular disease and stroke 2.Breast, prostate, and other forms of cancer 3.Diabetes (primarily type 1) 4.Allergies 5.Impaired cognition Joossens, J.V., Geboers, J., and Kesteloot, H. (1989). Nutrition and cardiovascular mortality in Belgium. Acta Cardiol., 44, 157-182. Larsson, S., Mannisto, S., Virtanen, M., Kontto, J., Albanes, D., and Virtamo, J. (2009). Dairy foods and risk of stroke. Epidemiology, 20(3), 355-360. Gerstein, H. (1994). Does cow’s milk cause type I diabetes mellitus? A critical overview of the clinical literature. Diabetes Care 17:13-19. Iacono, G., Carroccio, A., Cavataio, F., Montalto, G., Cantarero, M., and Notarbartolo, A. (1995). Chronic constipation as a symptom of cow milk allergy. J Pediatrics, 126:34- 39. Hebert, J., Hurley, T., Olendzki, B., Tea, J., Ma, Y., & Hampl, J. (1998). Nutritional and socioeconomic factors in relation to prostate cancer mortality: a cross-national study. J Nat Cancer Inst, 90(21), 1637-1647. Eskelinen, M., Ngandu, T.; Helkala, E., Tuomilehto, J., Nissinen, A., Soininen, H., and Kivipelto, M. (2008). Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study. International Journal of Geriatric Psychiatry, 23(7), 741-747. Eating cow’s milk equals a higher risk of:

34 Got Milk??? Got?: 1.Brucellosis and listeria: highly contagious bacteria 2.Bovine leukemia 3.Bovine immunodeficiency virus 4.Mycobacterium paratuberculosis: causes Johne's disease, which is related to Chrone’s disease 5.Camplyobacter 6.Dioxins and other chlorinated pesticides and herbicides 7.Pus, blood, urine, and feces… Yuck!

35 Buy a blender if you do not already have one and make smoothies… My Smoothie Recipe 1. 1 cup of water or rice, soy, almond, or hazelnut fluid if you prefer a liquid with a taste 2. A couple of servings of some fresh uncooked leafy green (collards, kale, red kale, chard, bok choi, mustard, dandelion, spinach, Romaine lettuce, etc.) 3. Any combination of about 2 cups of fruit (apple, pear, banana, cherry, blueberry, blackberry strawberry, raspberry, peach, mango, pineapple, apricot, asai, or anything to your taste); definitely use some frozen fruit to give it the refreshing consistency 4. A couple of ounces or handfuls of some combination of various raw nuts or seeds (flax, pumpkin, Brazil nut, pecan, walnut, cacao, chia seed, etc.) 5. A shiitake mushroom

36 6. A handful of cauliflower, broccoli, or other Brassica plants 7. ¼ of a teaspoon of dulse or kelp 8. ¼ of a teaspoon of turmeric 9. ¼ of a teaspoon of fenugreek 10. A handful of broccoli, sunflower, or other sprouts 11. 1 ounce of camu, maca, and/or pomegranate powder This goes in the blender and makes about 1.25 liters of a smoothie. I constantly rotate the foods that I use, so I get a good mix of nutrients. Besides always tasting good, they also always taste differently each time depending on the mixture of the ingredients. I imagine it will take you a few times to get the consistency the way you want it. I do not think you will be disappointed once you do. All you need is a good blender and you are on your way. Remember to use some frozen fruit to give it that “smoothie” consistency.

37 An objective of Healthy People 2020 is that adults exercise for at least 30 minutes of moderate physical activity for most, if not all, days of the week. A physically active lifestyle has been associated with health benefits that include improved control of hypertension, diabetes, obesity, hyperlipidemia, and reduced overall morbidity and mortality. Typically, 25% of Americans did not participate in any leisure time physical activities in the previous month. Blair, S., Kampert, J., Kohl, H., et al. (1996). Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA, 276, 205-2010. Helmrich, S., Ragland, D., Leung, R., and Paffenbarger, R., (1991). Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med, 325, :147-52. United States Department of Health and Human Services. (1996). Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: United States Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion. Report No.: 017-023-00196- 5. Dipietro, L., Dziura, J., and Blair, S. (2004). Estimated change in physical activity levels (PAL) and prediction of 5-yr weight change in middle-aged men: The aerobics center longitudinal study. Int J Obes and Related Met Dis, 28, 1541-1547. What about exercise?

38 1 pound (2.2 kg) of fat = 3,500 calories. After age 25, people typically gain a pound (2.2 kg) of weight per year. We also lose about.25 (.5 kg) to.5 pounds (1.1 kg) per year of lean body tissue, mostly from muscle and bone. The loss of lean tissue is closely associated with reductions in physical activity. The net result is 45 pounds (20.5 kg) of extra body fat by the age of 55 years. Weight Control

39 Exercise Will... 1.Be the primary method to burn calories, maintain a healthy energy balance, and lose weight. 2.Strengthen the myocardium (heart muscle) to maintain a normal pressure. 3.Increase the capacity of your lungs, i.e., your ventilation rate. 4.Raise HDL cholesterol and lower LDL and total cholesterol.

40 Exercise Will... 5.Improve your mood, thus making you feel good about yourself. 6.Decrease your risk or symptoms of depression and anxiety. 7.Enhance your sleeping patterns. 8.Relieve stress at least partially through the release of endorphins. 9.Increase efficiency of joint action and protection from injury.

41 Exercise Will... 10. Increase your proportion of fat free mass. 11. Increase your muscle mass (hypertrophy). 12. Increase the strength of your muscles and connective tissues. 13.Improve your capacity to perform activities. 14. Increase your bone mineral content. 15. Assist in digestion and elimination.

42 Exercise Recommendations The WHO recommends that people engage in at least 30 minutes of physical activity almost every day to prevent the occurrence of chronic disease. 1. Activities that are liked should be picked to increase adherence. 2. Exercising all muscles is very important. 3. Choose moderate kinds of activity, like brisk walking. 4. Work up to the goals slowly without experience in a regular exercise program.

43 Exercise Recommendations (American College of Sports Medicine) Four Primary Components of Designing an Exercise Program: 1.Frequency: How many days per week? 2.Intensity: What percentage of maximal heart rate? 3.Duration: How long in a given bout? 4.Mode: What type of exercise?

44 Exercise Recommendations ACSM and AHA recommend: 1. Moderate-intensity aerobic physical activity for a minimum of 30 minutes five days/week or vigorous intensity aerobic activity for a minimum of 20 minutes three days/week. 2. 8-10 strength-training exercises be performed on two or more nonconsecutive days/week using the major muscle groups. To maximize strength development, perform 10-15 repetitions for each exercise in a progressive manner. 3. Activities that maintain or increase flexibility on at least two days/week for at least 10 minutes/day. 4. To reduce risk of injury from falls, community-dwelling older adults with substantial risk of falls (e.g., with frequent falls or mobility problems) should perform exercises that maintain or improve balance. Haskell, W., et al. (2007). Physical Activity and Public Health Updated Recommendation for Adults From the American College of Sports Medicine and the American Heart Association. Circulation., 116, 1081-1093.

45 Exercise Recommendations Other Considerations: 1. Hydration is important to maintain homeostasis and recovery. 2. Pre- and post-exercise supplementation with carbohydrates and protein maximize recovery.

46 The Physical Activity Bottom Line A consistent and intense exercise program will help build and maintain muscle and some level of cardiovascular fitness. A combination of weight training, cardiovascular conditioning, and stretching are components of a complete exercise program. Intensity and Consistency are the 2 primary keys to any training program!





51 Why is the supply of monosaccharides important? Glycoprotein synthesis directed by genes is supported… Kornfeld, R. & Kornfeld, S. (1985). Assembly of asparagine-linked oligosaccharides. Annual Review of Biochemistry, 54, 631-664.


53 The Effect of an Aloe Polymannose Multinutrient Complex on Cognitive and Immune Functioning in Alzheimer's Disease Lewis, J. E., McDaniel, H. R., Agronin, M., Loewenstein, D., Riveros, J., Mestre, R., Martinez, M., Colina, N., Abreu, D., Konefal, J., Woolger, J. M., & Ali, K. H. (2013). The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease. The Journal of Alzheimer's Disease, 33, 393-406, DOI 10.3233/JAD-2012-121381.



56 An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults.

57 Results… Ali, K. H., Melillo A., Leonard S., Asthana, D., Woolger, J. M., Wolfson, A. H., McDaniel, H.R., & Lewis, J. E. (2012). An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults. Functional Foods in Health and Disease, 2(7), 265-279.


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