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Active Hectose Correlated Compound (AHCC) The World’s Most Researched Immune Supplement.

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Presentation on theme: "Active Hectose Correlated Compound (AHCC) The World’s Most Researched Immune Supplement."— Presentation transcript:

1 Active Hectose Correlated Compound (AHCC) The World’s Most Researched Immune Supplement

2 1. Introduction

3 What is AHCC? Naturally-derived complex compound Created by reacting specific enzymes with Several subspecies of hybridized medicinal mushrooms Unique compound formed through proprietary cultivation method and a patented manufacturing process Not a mushroom complex Cannot be duplicated and is not found in typical mushrooms Low molecular of 5,000 Daltons as compared to other immune ingredients (rice bran, beta-glucans and standard mushroom extracts are usually ~200,000 Daltons) Biological response modifier with strong immuno-modulating properties Shown in scientific research to increase activity of white blood cells White blood cells protect against & destroy abnormal cells (viruses, bacteria, parasites) Increased activity of Natural Killer (NK), B, B Helper, Killer T, Lymphokine Activated Killer (LAK) cells, Macrophage and Cytokines

4 AHCC Production Facility Sapporo, Japan

5 The Case for AHCC Supported by over 100 studies Over 4,000 patients has been involved in clinical trials Researched by over 30 prestigious institutions worldwide New studies presented annually at the AHCC Research Symposium Used in over 700 clinics worldwide Over 17 years of use in Japan and 6 years in the U.S. Countless anecdotal evidence #1 Selling Immune Supplement in Japan Subject of more than 10 books in Japan Endorsement of hundreds of physicians world-wide Won multiple recognitions including Nutracon Best Product (2002)

6 Books on AHCC

7 AHCC Research in the U.S. UT, Anderson Cancer Center UC, Davis Cancer Center Brigham and Women’s Hospital (Harvard) Faulkner Hospital (Harvard) Columbia Presbyterian (Holistic Urology) Yale School of Medicine, Rheumatology SUNY Binghamton, Biological Sciences UT Houston Medical, Surgery Drexel University, Bioscience and Biotechnology

8 Annual Research Symposium

9 2. Science and Research behind AHCC

10 The Immune System - Physiology Complicated series of cells that include: Natural killer (NK-cells) ■ Cytokines Macrophages ■ Interleukins T and B cells ■ Mast cells Substances they release Histamines Leukotrienes Others Modern science still has not yet figured it all out

11 Misfiring of the Immune System Assault on the immune systems causes: Decreased functioning of the natural killer (NK) cells Decreased functioning of the T-cells and macrophages Suppression of IL-2 Overproduction of IL-6 and other inflammatory cytokines Long-term impact: chronic illness The immune system plays a key part in human health and must be a key focus of preventative medicine

12 Natural Killer Cells Serves a dual function Cytotoxic destroyer Immuno-regulator Sentinel cells – first line of defense against invading pathogens (viruses, bacteria, cancer cells) Critical Role of NK cells Cancer sells are produced continuously in the body NK cells must remove them before they multiply Proper functioning of NK cells is critical to human health

13 AHCC and NK Cells Increases NK cell activity by 300-fold Stimulates T-cells Stimulates Macrophages Stimulates Cytokines Appears to be able to stimulate and modulate Works on both the macrophages and the cytokines Valuable links and network messengers Can work in auto-immune disorders because it does not over- stimulate the immune system Built in dampening system Can be taken continuously Does not need to be stopped like other immune-enhancing supplements

14 Selected Published Research

15

16 AHCC and Liver Disease Non-drug treatment of choice in Japan for: Hepatitis C 10 th leading cause of death in the US Clinically proven to Reduce Viral Load (measure of effectiveness) by up to 85% Dose recommendations of 6g/day in divided doses Hepatocellular carcinoma uncommon cancer in the US Quite common around the world Can improve detoxification by inducing P450 enzymes and inhibiting phase II enzymes Protects liver from chemical induced injuries such as overdose of medications ▪ anti-inflammatory meds statin drugs ▪ over-consumption of alcohol Studies show: Extension of life Improvement in quality of life

17 The AHCC Liver Study Landmark human study Post-surgical liver cancer patients taking AHCC Showed a 14% higher rate of survival than those in the placebo group Only 49% of the patients in the AHCC group had recurrence of cancer compared to 67% in the control group.

18 AHCC and Immuno-senescence New term which has become very relevant Describes the deterioration of our immune system that occurs naturally as we age Increased risk of developing autoimmune disorders Increase frequency of infections (Pneumonia is still the #1 cause of death for the elderly in the US) Increased frequency of non-infectious diseases such as atrial fibrillation, diabetes, arthritis & high blood pressure But it can be delayed and this should be a key focus of modern preventative medicine

19 AHCC Cancer-Related Research Used in Asia and the U.S. to reduce side-effects of chemotherapy Reduce toxicity Improve quality of life Research supports the following modes of action: Increases Tumor Necrosis Factor Increases Gamma Interferon Increases IL-12 (all decrease when undergoing chemotherapy) Decreases circulating level of IAP (Immuno-suppressive acidic protein) Decreases circulating level of IAP and TGF-B (tumor growth factor– Beta) Multiple Studies in Japan for this Indication On formulary in over 700 hospitals as adjunct to Chemotherapy and Radiation Therapy Increasingly used in the U.S. with very positive reported results

20 Other Uses of AHCC in Clinical Practice Allergies Asthma Chronic Sinusitis Eczema Fibromyalgia Hives Rashes Seasonal Disorders Modulation of the cytokine defense mechanism “AHCC should be used as a daily supplement for the immune system, alongside a multivitamin” Raise CD-4 counts an important immune system cellular component Post-Chemotherapy HIV Lyme Disease Chronic Fatigue Osteoarthritis Cold and Flu Prevention Cold and Flu Treatment

21 Why AHCC is Compelling to Physicians Offers an effective balance between high levels of stimulation of the NK cell mediated pathways Documented clinical and basic science research at prestigious hospitals around the world Documented efficacy studies Significant anecdotal evidence / positive response of patients Documented safety studies No toxicity Very few and rare side-effects

22 Usage and Dosage Therapeutically Patients with highly comprised immune systems Recommended therapeutic dose: 3g daily Preventatively Health-conscious adults seeking to heighten their immune activity Recommended preventative/therapeutic does 500mg – 1g daily

23 Summary Biological Response Modifier with strong immuno-modulating properties Extensive clinical research Strong safety data Significant clinical usage Recommended for patients with: Immune disorders Liver disease Cancer Undergoing chemotherapy Chronic illnesses Illnesses directly caused by inflammation Important for prevention of lifestyle diseases

24 3. AHCC in Retail

25 Unparalleled research over 100 studies over 4,000 patients done by the world’s most universities Broad adoption in Asia #1 Selling Immune Supplement in Japan Used in over 700 clinics worldwide Widely used by mainstream physicians in Asia and the U.S. High bioavailability due to low molecular weight, significantly lower than other immune supplements (5,000 Da vs. 200,000 Da) Definitive mode of action: targeting Natural Killer and other white blood cells. AHCC Unique Selling Propositions

26 Retailer FAQ’s Who is the target customer? Anyone with a weakened immune system Healthy individuals seeking immune enhancement How is AHCC different from other mushrooms and arabinoxylan (MGN-3)? Greater bio-availability due to low molecular weight Unique compound with unique properties, not a mushroom complex or extract How should I position AHCC to my customers? The most researched product in the immune category Used in over 700 clinics worldwide The #1 immune supplement in Japan, taken daily along a multivitamin What is recommended dosage of AHCC? 500 mg to 1 gram/day - maintenance 3 grams/day - therapeutic Is AHCC safe for children and pets? Yes, dose based on body weight


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