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Necator americanus Reaction after penetration of infective larvae (iL3) Prof Rick Speare Tropical Health Solutions 22 July 2012.

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Presentation on theme: "Necator americanus Reaction after penetration of infective larvae (iL3) Prof Rick Speare Tropical Health Solutions 22 July 2012."— Presentation transcript:

1 Necator americanus Reaction after penetration of infective larvae (iL3) Prof Rick Speare Tropical Health Solutions 22 July 2012

2 101 iL3 have been placed on a pad under a bandage on the ventral surface of the wrist* Itching starts within 2 mins as iL3 begin to penetrate the skin * 101 iL3 was too high!

3 12 hr post-infection Penetration site is itchy Indistinct areas of erythema visible

4 1 day post-infection Erythema has increased Papules are forming

5 2 days post-infection Multiple papules formed Coallesced due to the large number of iL3 used

6 4 days post-infection Papules are increasing in size still

7 6 days post-infection Some papules are starting to vesiculate

8 7 days post-infection

9 8 days post-infection

10 9 days post-infection

11 10 days post-infection Vesiculation progresses

12 11 days post-infection At last! Signs that the lesions will disappear!

13 12 days post-infection

14 15 days post-infection

15 20 days post-infection Three weeks for the penetration reaction to resolve is 3 times longer than normal

16 Useful sources All images were original made by Rick Speare For additional information on experimental infections: Croese J, Speare R, Wood M, Melrose W. Allergy controls the population density of Necator americanus in the small intestine. Gastroenterology 2006;131(2): Allergy controls the population density of Necator americanus in the small intestine Croese J, Speare R. Intestinal allergy expels hookworms: seeing is believing. Trends in Parasitology 2006;22(12): Intestinal allergy expels hookworms: seeing is believing Hookworms at Tropical Health SolutionsTropical Health Solutions


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