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Survey Results & analysis for ATS Assembly on Respiratory Structure & Function Project Proposal Initiative.

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Presentation on theme: "Survey Results & analysis for ATS Assembly on Respiratory Structure & Function Project Proposal Initiative."— Presentation transcript:

1 Survey Results & analysis for ATS Assembly on Respiratory Structure & Function Project Proposal Initiative

2 Executive Summary This report contains a detailed statistical analysis of the results to the survey titled ATS Assembly on Respiratory Structure & Function Project Proposal Initiative. The results analysis includes answers from all respondents who took the survey in the 70 day period from Tuesday, May 12, 2009 to Monday, July 20, completed responses were received to the survey during this time. Survey Results & Analysis Survey: ATS Assembly on Respiratory Structure & Function Project Proposal Initiative Author: Filter: Responses Received: 71

3 Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development: 123 Ventilation/Persusion in artificial ventilation - heterogeneity of perfusion as a cause of hypoventilation: a forgotten issue Effects of air pollution (physical, chemical, biological) on airway/parenchyma structure and remodeling Exhaled breath analysis for desese diagnosis. Innovations in technology that may have utlity in the meidical field. Update on Methacholine challenge testing Transcriptional mechanisms of recovery from acute lung injury Altered surfactant metabolism in diseased lung lung morphogenesis Respiratory Health Effects of Climate Change The mechanisms and role of airway nerves in airway diseases. Exhaled breath analysis for disease diagnosis. Innovations in technology that will have future utility in the medical field. Update on Methacholine challenge testing lung repair in COPD Severe asthma: pathogenesis and new treatments Airway Smooth Muscle Cells anf Myofibroblasts as targets for treating asthma and COPD

4 Phenotyping of animal models of emphysema Quantitative lung imagingAlveolar cell and tissue mechanics pulmonary vasculopathy in metabolic disease:acute vs chronic inflammatory response pulmonary vascular response to inflammatory damage: regio-temporal specific "hot spots" cytoskeletal microdomains in endothelial repair Functional consequences of airway smooth muscle remodeling Origins of increased smooth muscle in asthma. Clinical trial of inhaled corticosteroids on airway smooth muscle hyperplasia. Airway smooth muscle hypertrophy or hyperplasia in COPD. The significance of the small airways in asthma: measurement, phenotypes & treatment. Complex behavior of the respiratory system in health and disease Cyclical recruitment of atelectasis as a mechanism of ventilator-associated lung injury exhaled breath analysis

5 oral-cavity interferences with measurements of exhaled trace constituents from airways Role of extracellular matrix in airway hyperesponsiveness Airway epithelial barrier function in health and disease Airway epithelial models of health and disease Airway Acid and Oxidative Stress-- Biochemical Impacts on Airway Function complex in vitro models: epithelial/endothelial, Epithelial/smooth muscle, Epithelial/leukocyte Interaction of nanoparticles with biological systems and subsequent effects - interaction with the lung, lung tissue and lung cells Electron tomography - 3D electron microscopy: interaction of nanoparticles with subcellular structures like cytoskeleton, organelles, the nucleus Nanoparticulate matter in pulmonary medicinal application; diagnistics, therapeutics (nanomedicine) miRNA in lung function and airway remodeling Dynamics of oxygen deliveryGas equation and it's clinical relationAtelectasis and it's management in context of mechanical ventilation COPD rehabilitationscreening upper mechanics for OSAneuromuscular/chest wall disorders

6 severe asthma phenotypesanimal models for rare pulmonary diseases therapeutic targets in chronic cough MODULATION OF SMALL AIRWAY INFLAMMATION IN ASTHMA WITH EXISTING & NEWER INHALERS INFLUENCE OF VARIOUS BREATHING MANOUVERS ON AIRWAY CALIBRE INCLUDING YOGIC BREATHING WHICH HAS IMMENSE POTENTIAL WHICH HAS NOT BEEN ADDRESSED YET. VARIABILITY IN ACUTE LUNG INJURY DUE TO DIFFERENT ETIOLOGICAL FACTORS, SEPSIS IN PARTICULAR Cardiopulmonary exercise capacity in obesity. Typical reporting may mask the fact that many obese are not deconditioned but rather symptomatic. A position document would be very helpful in the area. Obesity and respiratory function at rest and during exercise. Also, dyspnea on exertion. Tracheostomies in children - standards of care for ongoing management, bronchoscopy etc Dyspnea - more than altered mechanics ObesityRespiratory Muscles lung development in the extremely premature neonate, ventilation strategies for these patients In vitro modelling of healthy airwaysIn vitro respiratory drug delivery and testing

7 endothelial dysfuction in ARDSendothelial pathophysiology in pulmonary hypertension pulmonary circulation in ventilator injury ATS Methacholine Challange Guideline Update. last was is 1999 Pulmonary Physiology in the 21st century Innovations in testing and design. Exhaled Breath measurement for Disease. We had previouslt published a paper on detecting Lung cancer. Now we are looking at all disease. This I would like to chair as I have the background and expertise. Lung residenet stem cellsinducible prluripotent stem cellsmicroparticles Animal models of emphysemaInnate immune function in COPD Interaction of inflammatory and alveolar epithelial cells in acute lung injury The role of programmed cellular death in response to stress in resident lung cells stem cell researcheffect of nanoparticles in health and disease Pulmonary nontuberculous mycobacterial disease x-dr tuberculosisARDSMULTIRESISTANT ORGANISMS IN VAP Steroid resistance in structural cellsGlucocorticoid signalingAlternative therapy in Severe asthma New metabolic or lipid pathways that could modulate airway remodeling. Statins and airway disease. Air pollution and lung (dys)functionLung parenchymal structural components: how do they modify function Better understanting FOT and IOS data

8 The controversial role of RAGE in lung pathophysiology. Queisser MA et al.,Am J Respir Cell Mol Biol Sep;39(3): Reynolds PR et al.,Am J Respir Cell Mol Biol Jun 25 Sternberg DI et al., J Thorac Cardiovasc Surg Dec;136(6): Englert JM et al., Am J Pathol Mar;172(3): He M et al., Am J Physiol Lung Cell Mol Physiol Dec;293(6):L Mechanisms of alveolar protein clearance in the intact lung Am J Physiol Lung Cell Mol Physiol Apr;286(4):L Review The development of airway smooth muscle in utero and early life. Factors influencing cell number. The composition of the ectracellular matrix in asthma. Role of imaging in lung diseaseTranslation of new technologies to clinical practice Standards for performance for diagnostic and monitoring tools in critical care Airway wall remodellingSignal transduction cascades underlying development and severity of airway diseases Airway hyperresponsiveness; mechanisms and consequences Airway smooth muscle as a major actor in airway hyperresponsiveness: from whole muscle mechanics to the assesment of crossbridge properties. Statistical mechanics: a new way to establish a link between microscopic properties of airway smooth muscle and its bulk mechanical properties. Murine and other animal models of COPD Modeling airway hyperresponsivenessAging and the lung

9 1. (Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development:)

10 1. Ventilation/Persusion in artificial ventilation - heterogeneity of perfusion as a cause of hypoventilation: a forgotten issue Exhaled breath analysis for desese diagnosis. Transcriptional mechanisms of recovery from acute lung injury Respiratory Health Effects of Climate Change Exhaled breath analysis for disease diagnosis. lung repair in COPD Severe asthma: pathogenesis and new treatments Phenotyping of animal models of emphysema pulmonary vasculopathy in metabolic disease:acute vs chronic inflammatory response Functional consequences of airway smooth muscle remodeling Origins of increased smooth muscle in asthma. The significance of the small airways in asthma: measurement, phenotypes & treatment. Complex behavior of the respiratory system in health and disease Cyclical recruitment of atelectasis as a mechanism of ventilator-associated lung injury exhaled breath analysis oral-cavity interferences with measurements of exhaled trace constituents from airways Role of extracellular matrix in airway hyperesponsiveness Airway epithelial barrier function in health and disease Airway Acid and Oxidative Stress--Biochemical Impacts on Airway Function complex in vitro models: epithelial/endothelial, Epithelial/smooth muscle, Epithelial/leukocyte Interaction of nanoparticles with biological systems and subsequent effects - interaction with the lung, lung tissue and lung cells miRNA in lung function and airway remodeling

11 Cardiopulmonary exercise capacity in obesity. Typical reporting may mask the fact that many obese are not deconditioned but rather symptomatic. A position document would be very helpful in the area. Tracheostomies in children - standards of care for ongoing management, bronchoscopy etc Dyspnea - more than altered mechanics Obesity lung development in the extremely premature neonate, ventilation strategies for these patients In vitro modelling of healthy airways endothelial dysfuction in ARDS ATS Methacholine Challange Guideline Update. last was is 1999 Lung residenet stem cells Animal models of emphysema Interaction of inflammatory and alveolar epithelial cells in acute lung injury stem cell research Pulmonary nontuberculous mycobacterial disease x-dr tuberculosis Steroid resistance in structural cells New metabolic or lipid pathways that could modulate airway remodeling. Air pollution and lung (dys)function Dynamics of oxygen delivery COPD rehabilitation severe asthma phenotypes MODULATION OF SMALL AIRWAY INFLAMMATION IN ASTHMA WITH EXISTING & NEWER INHALERS

12 Airway wall remodelling Airway smooth muscle as a major actor in airway hyperresponsiveness: from whole muscle mechanics to the assesment of crossbridge properties. Murine and other animal models of COPD The controversial role of RAGE in lung pathophysiology. Queisser MA et al.,Am J Respir Cell Mol Biol Sep;39(3): Reynolds PR et al.,Am J Respir Cell Mol Biol Jun 25 Sternberg DI et al., J Thorac Cardiovasc Surg Dec;136(6): Englert JM et al., Am J Pathol Mar;172(3): He M et al., Am J Physiol Lung Cell Mol Physiol Dec;293(6):L The development of airway smooth muscle in utero and early life. Factors influencing cell number. Role of imaging in lung disease

13

14 Glucocorticoid signaling Statins and airway disease. Lung parenchymal structural components: how do they modify function Mechanisms of alveolar protein clearance in the intact lung Am J Physiol Lung Cell Mol Physiol Apr;286(4):L Review The composition of the ectracellular matrix in asthma. Translation of new technologies to clinical practice Signal transduction cascades underlying development and severity of airway diseases Statistical mechanics: a new way to establish a link between microscopic properties of airway smooth muscle and its bulk mechanical properties. Modeling airway hyperresponsiveness

15 3. (Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development:)

16 3. Update on Methacholine challenge testing lung morphogenesis Update on Methacholine challenge testing Alveolar cell and tissue mechanics cytoskeletal microdomains in endothelial repair Airway smooth muscle hypertrophy or hyperplasia in COPD. Nanoparticulate matter in pulmonary medicinal application; diagnistics, therapeutics (nanomedicine) Atelectasis and it's management in context of mechanical ventilation neuromuscular/chest wall disorders therapeutic targets in chronic cough VARIABILITY IN ACUTE LUNG INJURY DUE TO DIFFERENT ETIOLOGICAL FACTORS, SEPSIS IN PARTICULAR pulmonary circulation in ventilator injury Exhaled Breath measurement for Disease. We had previouslt published a paper on detecting Lung cancer. Now we are looking at all disease. This I would like to chair as I have the background and expertise. microparticles MULTIRESISTANT ORGANISMS IN VAP Alternative therapy in Severe asthma Better understanting FOT and IOS data Standards for performance for diagnostic and monitoring tools in critical care Airway hyperresponsiveness; mechanisms and consequences Aging and the lung Acute Lung Injury

17 Most DesirableDesirableSomewhat Desirable Not DesirableLeast Desirable Cytoskeletal dynamics in lung health and disease 25.4% (16)30.2% (19)28.6% (18)7.9% (5) Immune response in ventilator-injured lungs 14.3% (9)38.1% (24)23.8% (15)15.9% (10)7.9% (5) Advances in ventilator technology and modalities 15.9% (10)17.5% (11)42.9% (27)14.3% (9)9.5% (6) Osmotic stress and lung injury & repair 6.3% (4)28.6% (18)39.7% (25)14.3% (9)11.1% (7)

18 Cytoskeletal dynamics in lung health and disease(Acute Lung Injury)

19 Immune response in ventilator-injured lungs(Acute Lung Injury)

20 Advances in ventilator technology and modalities(Acute Lung Injury)

21 Osmotic stress and lung injury & repair(Acute Lung Injury)

22 Lung (Patho)Physiology and Mechanics

23 Most DesirableDesirableSomewhat Desirable Not DesirableLeast Desirable Murine models of asthma– strengths, weaknesses, opportunities and threats 16.7% (11)40.9% (27)25.8% (17)9.1% (6)7.6% (5) Neural control of the airways 15.4% (10)29.2% (19)40.0% (26)13.8% (9)1.5% (1) Modulation of the cough reflex 13.8% (9)24.6% (16)36.9% (24)16.9% (11)7.7% (5) TRP channels in airway pathobiology 8.1% (5)19.4% (12)43.5% (27)24.2% (15)4.8% (3) Quantifying emphysema in humans and mice 34.8% (23)19.7% (13)33.3% (22)10.6% (7)1.5% (1) Neuropeptide modulation airway mechanics in asthma 8.3% (5)30.0% (18)43.3% (26)15.0% (9)3.3% (2) Influence of the epithelium on airway calibre 23.4% (15)46.9% (30)20.3% (13)6.3% (4)3.1% (2) Small airway function: inflammation, airway calibre and heterogeneity 35.4% (23)47.7% (31)12.3% (8)4.6% (3)0.0% (0) Airway hyperresponsivenes s: molecules to man 36.9% (24)35.4% (23)20.0% (13)6.2% (4)1.5% (1) Role of lung surfactant in modulating airway mechanics in asthma 15.9% (10)38.1% (24)30.2% (19)11.1% (7)4.8% (3)

24 Gender differences in health, aging and lung disease 13.4% (9)34.3% (23)31.3% (21)16.4% (11)4.5% (3) Vascular barrier properties 8.1% (5)25.8% (16)43.5% (27)14.5% (9)8.1% (5) Interstitial matrix molecules and tissue mechanics 18.3% (11)40.0% (24)25.0% (15)10.0% (6)6.7% (4) Use of the forced oscillation technique 7.7% (5)24.6% (16)32.3% (21)20.0% (13)15.4% (10) Severe asthma – causes, consequences and treatment 41.5% (27)27.7% (18)18.5% (12)9.2% (6)3.1% (2) Pathobiology of rare lung diseases 12.3% (8)18.5% (12)33.8% (22)23.1% (15)12.3% (8) Aging of the pulmonary system 28.6% (20)41.4% (29)18.6% (13)8.6% (6)2.9% (2)

25 Murine models of asthma– strengths, weaknesses, opportunities and threats(Lung (Patho)Physiology and Mechanics)

26 Neural control of the airways(Lung (Patho)Physiology and Mechanics)

27 Modulation of the cough reflex(Lung (Patho)Physiology and Mechanics)

28 TRP channels in airway pathobiology(Lung (Patho)Physiology and Mechanics)

29 Quantifying emphysema in humans and mice(Lung (Patho)Physiology and Mechanics)

30 Neuropeptide modulation airway mechanics in asthma(Lung (Patho)Physiology and Mechanics)

31 Influence of the epithelium on airway calibre(Lung (Patho)Physiology and Mechanics)

32 Small airway function: inflammation, airway calibre and heterogeneity(Lung (Patho)Physiology and Mechanics)

33 Airway hyperresponsiveness: molecules to man(Lung (Patho)Physiology and Mechanics)

34 Role of lung surfactant in modulating airway mechanics in asthma(Lung (Patho)Physiology and Mechanics)

35 Gender differences in health, aging and lung disease(Lung (Patho)Physiology and Mechanics)

36 Vascular barrier properties(Lung (Patho)Physiology and Mechanics)

37 Interstitial matrix molecules and tissue mechanics(Lung (Patho)Physiology and Mechanics)

38 Use of the forced oscillation technique(Lung (Patho)Physiology and Mechanics)

39 Severe asthma – causes, consequences and treatment(Lung (Patho)Physiology and Mechanics)

40 Pathobiology of rare lung diseases(Lung (Patho)Physiology and Mechanics)

41 Aging of the pulmonary system(Lung (Patho)Physiology and Mechanics)

42 Airway Smooth Muscle & Airway Remodeling

43 Most DesirableDesirableSomewhat Desirable Not DesirableLeast Desirable Developing in vivo methods for measuring airway remodeling 35.9% (23) 18.8% (12)6.3% (4)3.1% (2) Epithelial- mesenchymal transition in airway and lung remodeling 22.2% (14)31.7% (20)33.3% (21)11.1% (7)1.6% (1) Vascular remodeling in pulmonary hypertension, asthma and COPD 31.7% (20)28.6% (18)27.0% (17)11.1% (7)1.6% (1) Airway smooth muscle remodeling and dysfunction in asthma and COPD 31.7% (20)39.7% (25)14.3% (9)12.7% (8)1.6% (1) Targeting airway remodeling in asthma treatment 29.7% (19)37.5% (24)20.3% (13)10.9% (7)1.6% (1) Apoptosis and fibrotic lung disease 20.6% (13)31.7% (20)27.0% (17)19.0% (12)1.6% (1) Association between asthma phenotype and airway remodeling 31.3% (20)25.0% (16)29.7% (19)7.8% (5)6.3% (4)

44 Developing in vivo methods for measuring airway remodeling(Airway Smooth Muscle & Airway Remodeling)

45 Epithelial-mesenchymal transition in airway and lung remodeling(Airway Smooth Muscle & Airway Remodeling)

46 Vascular remodeling in pulmonary hypertension, asthma and COPD(Airway Smooth Muscle & Airway Remodeling)

47 Airway smooth muscle remodeling and dysfunction in asthma and COPD(Airway Smooth Muscle & Airway Remodeling)

48 Targeting airway remodeling in asthma treatment(Airway Smooth Muscle & Airway Remodeling)

49 Apoptosis and fibrotic lung disease(Airway Smooth Muscle & Airway Remodeling)

50 Association between asthma phenotype and airway remodeling(Airway Smooth Muscle & Airway Remodeling)

51 Integrating Structure and Function: Imaging and Modeling

52 Most DesirableDesirableSomewhat Desirable Not DesirableLeast Desirable Lung imaging: integrating lung and cell mechanics 33.3% (21)44.4% (28)12.7% (8)4.8% (3) Mathematical modeling of lung disease 11.1% (7)27.0% (17)38.1% (24)15.9% (10)7.9% (5) Imaging: novel techniques 20.3% (13)46.9% (30)21.9% (14)7.8% (5)3.1% (2) Imaging: early detection of disease 35.9% (23)28.1% (18)20.3% (13)14.1% (9)1.6% (1) Imaging: physiological mechanisms in health and disease 38.1% (24)33.3% (21)19.0% (12)7.9% (5)1.6% (1) Ventilation heterogeneity: theoretical modeling to imaging 23.4% (15) 32.8% (21)17.2% (11)3.1% (2) Nanotechnology in detecting and treating lung disease 25.0% (16)31.3% (20)23.4% (15)14.1% (9)6.3% (4)

53 Lung imaging: integrating lung and cell mechanics(Integrating Structure and Function: Imaging and Modeling)

54 Mathematical modeling of lung disease(Integrating Structure and Function: Imaging and Modeling)

55 Imaging: novel techniques(Integrating Structure and Function: Imaging and Modeling)

56 Imaging: early detection of disease(Integrating Structure and Function: Imaging and Modeling)

57 Imaging: physiological mechanisms in health and disease(Integrating Structure and Function: Imaging and Modeling)

58 Ventilation heterogeneity: theoretical modeling to imaging(Integrating Structure and Function: Imaging and Modeling)

59 Nanotechnology in detecting and treating lung disease(Integrating Structure and Function: Imaging and Modeling)

60 Respiratory and Peripheral Muscle Biology/Physiology

61 Most DesirableDesirableSomewhat Desirable Not DesirableLeast Desirable Cell and molecular mechanisms for respiratory and peripheral muscle failure 19.4% (12)32.3% (20)33.9% (21)12.9% (8)1.6% (1) Respiratory and peripheral muscle dysfunction in sepsis 18.0% (11)27.9% (17)19.7% (12)24.6% (15)9.8% (6) Skeletal muscle weakness in COPD 17.5% (11)34.9% (22)27.0% (17)14.3% (9)6.3% (4) Respiratory muscle failure in muscular dystrophy 6.5% (4)38.7% (24)22.6% (14)21.0% (13)11.3% (7) Acquired weakness syndromes in critical illness 12.7% (8)34.9% (22)25.4% (16)15.9% (10)11.1% (7) Mechanical ventilation induced diaphragm dysfunction 11.3% (7)32.3% (20)27.4% (17)22.6% (14)6.5% (4) Mechanisms for exercise endurance in asthma and COPD 23.1% (15)27.7% (18) 13.8% (9)7.7% (5) Exercise rehabilitation programs for COPD 21.5% (14)24.6% (16)29.2% (19)13.8% (9)10.8% (7)

62 Cell and molecular mechanisms for respiratory and peripheral muscle failure(Respiratory and Peripheral Muscle Biology/Physiology)

63 Respiratory and peripheral muscle dysfunction in sepsis(Respiratory and Peripheral Muscle Biology/Physiology)

64 Skeletal muscle weakness in COPD(Respiratory and Peripheral Muscle Biology/Physiology)

65 Respiratory muscle failure in muscular dystrophy(Respiratory and Peripheral Muscle Biology/Physiology)

66 Acquired weakness syndromes in critical illness(Respiratory and Peripheral Muscle Biology/Physiology)

67 Mechanical ventilation induced diaphragm dysfunction(Respiratory and Peripheral Muscle Biology/Physiology)

68 Mechanisms for exercise endurance in asthma and COPD(Respiratory and Peripheral Muscle Biology/Physiology)

69 Exercise rehabilitation programs for COPD(Respiratory and Peripheral Muscle Biology/Physiology)

70 Other:

71 Most DesirableDesirableSomewhat Desirable Not DesirableLeast Desirable Hypertonic saline inhalation for cystic fibrosis 11.1% (7)12.7% (8)46.0% (29)23.8% (15)6.3% (4) Genetics of COPD21.9% (14)34.4% (22)25.0% (16)10.9% (7)7.8% (5)

72 Hypertonic saline inhalation for cystic fibrosis(Other:)

73 Genetics of COPD(Other:)


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