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Oxytocin and Resilience. Oxytocin The “Love Hormone” ◦ Trust ◦ Positive feelings ◦ Anxiolytic ◦ Sex and pair bonding ◦ Empathy Produced: Hypothalamus.

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Presentation on theme: "Oxytocin and Resilience. Oxytocin The “Love Hormone” ◦ Trust ◦ Positive feelings ◦ Anxiolytic ◦ Sex and pair bonding ◦ Empathy Produced: Hypothalamus."— Presentation transcript:

1 Oxytocin and Resilience

2 Oxytocin The “Love Hormone” ◦ Trust ◦ Positive feelings ◦ Anxiolytic ◦ Sex and pair bonding ◦ Empathy Produced: Hypothalamus Released: Posterior Pituitary Gq – PLC/IP3 pathway

3 Traumatic

4 Scantamburlo 07 Anxiety Depression R=-0.58 R 2 =0.33 P=0.003 R=-0.61 R 2 =0.37 P=0.005

5 Chaviaras 10 Oxytocin agonist Used in humans Less locomotion when given i.p.?

6 Stress HPA axis

7 H ypothalamus P ituitary A drenal Stress

8 HPA axis

9 Different Polymorphisms Chen 2011 ◦ Rs53576  GG  GA  AA Thompson 2011 ◦ Rs  GG  GA

10 Thompson 11 Mother with depression?Rs ? Hi / Low adversity+ / - polymorphisim Environment x Genetics

11 Thompson 11

12 Receptor Polymorphism Rs53576 ◦ Adenosine (A) instead of a Guanine (G) ◦ Opposite effect of adding Oxytocin ◦ Non-coding intron mutation!  “the genetic variant investigated in this study in likely a marker for still-unidentified functional variants of the gene”

13 Chen 11 Hardy-Weinberg equilibrium %

14 Chen 11 Meanwhile in Germany… Social SupportNO Social Support N = 203

15 Chen 11 Trier Social Stress for Groups

16 Chen 11 *

17

18 Take home Oxytocin has antidepressant/anxiolytic action ◦ Promotes resilience Responsible for positive effects of social support Receptor polymorphisms appear to confer a loss of function


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