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TNBC Supplementary Figure 1 d e f HD PEST Notch pathway activation (TNBC cases only) c a b NOTCH1 NOTCH2 NOTCH3
Supplementary Figure 2 NOTCH4 a b
Supplementary Figure 3 TCGA-BH-A1FC, ∆exon21-27 Canonical NOTCH1 transcript 34 33 32 31292725232119 302826 242220 18 TCGA-A2-A0T0, chr9:139,390,528-139,390,695 deletion TCGA-A8-A08X, chr9:139,391,422 inter-chromosomal translocation Canonical NOTCH2 transcript TCGA-AO-A0J6, chr1:120,458,725-120,458,786 deletion a b 34 33 32 31292725232119 302826 242220 18 To: chr14:30,447,409 c TCGA-AN-A0AR, BRD4(exon1)-NOTCH3(exon 26) fusion & chr19:15,270,914-15,272,239 deletion 33 32 31 29 27 30 28 26 25 NOTCH3BRD4EPHX3
TCGA-BH-A1FC Tumor TCGA-BH-A1FC Matched Normal a bc d 9q34.3 27 234 28 1 NOTCH1 2120 234 28 1 20 Exon 21-27 deletion S1S2S3 Supplementary Figure 4 ef
19p13.13 332625 21 3326 12 1 50Kb NOTCH3 BRD4 1226bp deletion ab c Supplementary Figure 5 S1S2S3 Notch3 wild-type Mutant Notch3 in TCGA-AN-A0AR Notch3 p.M1583Notch3 p.P2067Rfs*84 d
Pfizer Confidential │ 6 TCGA-A2-A0T0TCGA-A8-A08XTCGA-A8-A0J6 RNA-Seq in tumor WXS in tumor WXS in matched normal abc Supplementary Figure 6
a b Supplementary Figure 7
Chromosome Position (MB) log2 CN ratio c a b d Supplementary Figure 8 e f g TGTGAGCAGA CCCGCTGGTT h i Exon 34 Intron 30 Junction CCACTGGGCCCC CTGGGGTGATACCGCAGG j k l 1p121q21.1 chr1: 144548815 chr1: 120458385 NOTCH2 34 272 1 Intronic 34* 272 1 chr1: 144548815 127293133 1p121q21.1 2 28 30 3234 1272931332 28 30 32 34’ * 5’ - - 3’ NOTCH2Intronic 9q34.3 27 2 2 34 30 31 34 34*31 3031 1 1 NOTCH1 chr9:139390847 chr9:139396004 272931332 28 30 3234 9q34.3 NOTCH1 1 5’ - - 3’ 1272931332 28 30 32 30 31 34’ * chr9:139396004
Supplementary Figure 9 TCTCGAGATGGAGATTGGAGATTG wt deletion GCATTCCAACTTTAGCACAAGG CCAGCTACAGCTATGCTGA AGCGACGTGGGCTCTCCTGGGGC GGCAGCGACGTGGGCAGGGCGGGGCTCTCCTGGGGC c a b d e f g 9q34.3 27 234 28 1 NOTCH1 34* 28 1 27* 4q32.3 chr4:166105738 Intergenic chr9:139390607chr9:139397768 chr9:139439295 9q34.3 4q32.3 Intergenic 1272931332 28 30 3234 NOTCH1 1293133 28 30 32 5’ - - 3’ 34’ * chr4:166105738 Alt. splicing chr9:139390682 – chr4:166107169 27’ unsplicedspliced
Supplementary Figure 10 a b HCC1937 HBCx5 HBCx17 HBCx12B AA0869 MDA-MB-231 BT-474 HCC1806
Supplementary Figure 11 a b 80 KDa 110 KDa 160 KDa NICD1 MDAMB231 - -++ HBCx14 - -++ PF4014 HCC1599 - -++ GAPDH 40 KDa c HBCx14 HCC1599HBCx12B - -++ - -++ - + - + PF4014 110 KDa 160 KDa NICD1 GAPDH 40 KDa 110 KDa 160 KDa NICD1 HCC1937 HBCx14 HCC1599 - ++ -- ++ PF4014 GAPDH 40 KDa -
Notch wt Notch mutant Notch wt Notch mutant Notch wt Notch mutant Notch wt Notch mutant Supplementary Figure 12 PF-4014 * * * * * ** * *
Notch wt Notch mutant Notch wt Notch mutant Notch wt Notch mutant Notch wt Notch mutant Supplementary Figure 13 PF-4014 * * * * ** * * * * * * * *
Supplementary Figure S1 FPKM ESRP1ESRP2 normaltumor Supplementary Figure S1. ESRP1 and ESRP2 mRNA expression in 65 normal kidney samples and 474 ccRCC.
Supplementary data d a c d ab b Figure S1. Quantification of the Western blot data in figure 4C. The area density of each band was measured with a UVP.
Chr2 (115,918,613) exon3 Typical DNA read and direction Chr2 Deletion (multiple exons of DPP10 lost) Chr2 (116,314,797) 29 transcriptome read map to this.
Supplementary Figure 1. Somatic mutation spectrum # Substitutions # Substitutions per Mb b c a Repeats Pseudogenes Whole genome Splice sites Non-coding.
(z=7) (z=7) (z=7) (z=7) MSMS/MS Ba 7702 Bc AH819 Bc Bc AH259 b y y b b 9 2+ b y 33.
Supplementary Figure S1 Percentage of peaks from Trf1 +/+ p53 -/- -Cre vs Trf1 / p53 -/- -Cre comparison that are located in non subtelomeric and subtelomeric.
945 Kb Kb 1,900 Kb 1,640 Kb 1,120 / 1,100 Kb 815 Kb 450 Kb 915 Kb 680 Kb 555 Kb 610 Kb
56.) Congruent Figures—figures that have the same size and shape 57.) Similar Figures—figures that have the same exact shape but different size (angles.
Supplementary Figure 1 List of top 50 most abundantly expressed lncRNAs and mRNAs in HP and PFC from RNAseq. Expression abundance of lncRNAs and mRNAs.
Similar and Congruent Figures. Similar figures have the same shape, but not the same size. They must have the same ratio of side lengths Congruent figures.
Exon 1 Exon 2 Exon 3 Exon 4 TAG = Hypermethylation at CG sites = Background (WT) mCG phyA’ WT WT (Col-0) methylation profile from
B C Supplementary Figure 1 Control X0 Control X9 -HBx (mAb) -HBx (rabbit serum) ABCEFD aa ABCEF X0 X9 ( D) A
Supplementary Figure 1. Outline of the MRC UKALL 2003 trial protocol detailing drugs used and timing schedules for the three regimens. Patients were allocated.
If three sides of one triangle are congruent to the three sides of another triangle, then the two triangles are congruent. If AB = DE, BC = EF, AC.
Mutational analysis of 35 bladder cancer cell lines using RNA-seq.
Wu et al., Supplementary Fig 1 Supplementary Figure 1: The depletion of BRG1 in HeLa cells has no effect on cell proliferation. Sh- empty vector was used.
Date of download: 6/22/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Identification of a Novel TP53 Cancer Susceptibility.
6.1: The Law of Sines. Law of Sines In any triangle ABC (in standard notation): a__ = b__ = c__ Sin A Sin B Sin C * Used with AAS and SSA problems.
Proving RightTriangles Congruent Free powerpoints at
Garcia_Figure S1 Supplementary figures wt rm7 16 g total protein 20 g total protein YFP (27KDa – 33KDa) -Tubulin (50KDa) Q0Q24 Q40Q35 wt wt rm7 wt.
Unscrambling the genomic chaos of osteosarcomas reveals a recurrent gene fusion Leonardo A. Meza-Zepeda, PhD Department of Tumor Biology Institute for.
The mating type locus Chr. III. The MAT locus information The MAT locus can encode three regulatory peptides: - a1 is encoded by the MATa allele -
Similarity & Congruency Dr. Marinas Similarity Has same shape All corresponding pairs of angles are congruent Corresponding pairs of sides are in proportion.
مدیریت تکنولوژی دکترسهیل سرمد سعیدی. فصل اول مفاهیم پایه.
Chapter 4 Ms. Cuervo. Vocabulary: Congruent -Two figures that have the same size and shape. -Two triangles are congruent if and only if their vertices.
Similar Figures Notes. Solving Proportions Review Before we can discuss Similar Figures we need to review how to solve proportions…. Any ideas?
How DNA is used in Heredity Reading the Book of Life, or Gene Expression.
Homeobox leucine zipper protein 9 (HAT9) -AT2G Homeodomain(s) -Leucine Zipper Motif -DNA Binding -Dimerization ?? ~ Helix-turn-helix 5’3’ FWRV.
Blue – 3/2/2015 Gold – 3/3/2015. Bell Ringer: Finish the two-column proof. Prove:ΔLMN ΔPON 2. LNM PNO 2. _________________ StatementsReasons 3.
- KLF6 869 bp IHH HepG2 Hep3B HuH bp- 800 bp- 700 bp- 600 bp- SV1 715 bp SV2 743 bp SV3 745 bp IHH HepG2 Hep3B HuH Percentage of.
LECTURE 2 Splicing graphs / Annoteted transcript expression estimation.
Supplemental Figure 1. Bias-corrected NGS bioinformatics strategies. Paired-end DNA sequencing reveals the sequence of the genomic clone, the sample ID.
Do Now Draw and label a figure for each relationship:
Tumor Supressor Gene Non-functional TSG Mutations increasing risk of cancer “Loss of function” mutation Proto-oncogene Oncogene (Hyperactive or unregulated.
There are five ways to prove that triangles are congruent. They are: SSS, SAS, ASA, AAS, We are going to look at the first three today.
( ) 2.2 FC autism control FGR1OP2. ( ) 1.4 FC autism control SMAD2.
Levels at which eukaryotic gene expression is controlled
Module 4: Understanding KO designs Mark Thomas Wellcome Trust Sanger Institute.
7.2 Similar Polygons. Similar Polygons In geometry, two figures that have the same shape are called similar. Two polygons are similar polygons if corresponding.
Definitions of the Gene
Proving Triangles Congruent. Two geometric figures with exactly the same size and shape. Review of Congruence A C B DE F.
Supplementary Figure S1. The exon-intron structure of the U22HG and GAS5 genes. (A) A comparative analysis of the U22HG gene in humans, frog, fugu, and.
Chapter 5 Introduction to Trigonometry: 5
What is so memorable about CREBBP? (RSTS; RTS, CBP CBP/MOZ FUSION GENE, CREB-binding protein)
Blue – 3/9/2015 Gold – 3/10/2015. Last 2 classes, we talked about 3 ways we can determine triangle congruence. CPCTC – All 3 sides and 3 angles of.
1 Press Ctrl-A ©G Dear2010 – Not to be sold/Free to use CongruentTriangles Stage 4 - Year 9.
The mitochondrial genome Nucleoid, 75kb, 10 proteins, tRNA, rRNA, „optional“ introns Relaxed codon usage Variation in the code, trp, met, thr.
P247. Figure 9-1 p248 Figure 9-2 p251 p251 Figure 9-3 p253.
1 Q1-Q3 results Roderic Guigó' s lab April 11 th 2007 conference call.
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