8 This slide shows how the hydrophobic and Fig. 7-2This slide shows how the hydrophobic andhydrophilic regions are set up.WATERHydrophilicheadFigure 7.2 Phospholipid bilayer (cross section)HydrophobictailWATER
9 Phospholipid bilayer Hydrophobic regions of protein Hydrophilic Fig. 7-3PhospholipidbilayerFigure 7.3 The fluid mosaic model for membranesHydrophobic regionsof proteinHydrophilicregions of protein
12 Different types of phospholipids making up the membrane
13 Fig. 7-4TECHNIQUERESULTSExtracellularlayerProteinsInside of extracellular layerKnifeFigure 7.4 Freeze-fracturePlasma membraneCytoplasmic layerInside of cytoplasmic layerFreeze-fracture studies of the plasma membrane supported the fluid mosaic model
15 Biology Animations Fig. 7-5 Lateral movement (~107 times per second) Flip-flop(~ once per month)(a) Movement of phospholipidsFluidViscousBiology AnimationsUnsaturated hydrocarbontails with kinksSaturated hydro-carbon tails(b) Membrane fluidityFigure 7.5 The fluidity of membranesCholesterol(c) Cholesterol within the animal cell membrane
16 This experiment shows how the proteins can move about the membrane. Fig. 7-6This experiment shows how the proteins can move about the membrane.RESULTSMembrane proteinsMixed proteinsafter 1 hourMouse cellFigure 7.6 Do membrane proteins move?Human cellHybrid cell
18 Unsaturated hydrocarbon tails with kinks Saturated hydro- carbon tails Fig. 7-5bFluidViscousUnsaturated hydrocarbontails with kinksSaturated hydro-carbon tailsFigure 7.5b The fluidity of membranes(b) Membrane fluidity
19 Would you expect an amoeba that lives in a pond in a cold northern climate to have a higher or lower percentage of saturated fatty acids in its membranes during the summer as compared to the winter?
23 Fig. 7-7 Fibers of extracellular matrix (ECM) Glyco- Carbohydrate proteinCarbohydrateGlycolipidEXTRACELLULARSIDE OFMEMBRANEFigure 7.7 The detailed structure of an animal cell’s plasma membrane, in a cutaway viewCholesterolMicrofilamentsof cytoskeletonPeripheralproteinsIntegralproteinCYTOPLASMIC SIDEOF MEMBRANE
32 Membranes are bifacial Carbohydrates (making glycoproteins and glycolipids) on outer surfacePeripheral proteins generally on cytoplasmic surfaceProteins have a distinct orientation, ie…receptor proteins oriented at surface, enzyme proteins oriented toward cytoplasm
35 ER 1 Transmembrane glycoproteins Secretory protein Glycolipid Golgi 2 Fig. 7-10ER1TransmembraneglycoproteinsSecretoryproteinGlycolipidGolgiapparatus2VesicleFigure 7.10 Synthesis of membrane components and their orientation on the resulting membrane3Plasma membrane:Cytoplasmic face4Extracellular faceTransmembraneglycoproteinSecretedproteinMembrane glycolipid
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