1. 2. Metalation of  -Deficient Heteroaromatics

2. Metalation of  - Deficient Heteroaromatics. Bare Pyridines. Acidity Considerations Metalation of  - Deficient Heteroaromatics. Bare Pyridines. Acidity Considerations

3. Nu - Addition to Pyridines. Synthetic Utility

4. Directed ortho Metalation (DoM) Reactivity of Pyridines

5. C-based Pyridine DoM. DMG = CONEt 2 Synthetic Application C-based Pyridine DoM. DMG = CONEt 2 Synthetic Application

6. C-based Pyridine DoM. DMG = CON - R HetRing Annelation C-based Pyridine DoM. DMG = CON - R HetRing Annelation

7. C-Based Methoxypyridine DoM. DMG = CH(O - )NR 2

8. HetAtom - Based Pyridine DoM. DMG = OCONR 2 HetAtom - Based Pyridine DoM. DMG = OCONR 2

9. HetAtom - Based Pyridine DoM. DMG = OCONR 2. Methodology HetAtom - Based Pyridine DoM. DMG = OCONR 2. Methodology

10. HetAtom - Based Pyridine DoM. DMG = OCONR 2. Anionic ortho-Fries Rearrangement HetAtom - Based Pyridine DoM. DMG = OCONR 2. Anionic ortho-Fries Rearrangement

11. HetAtom - Based Pyridine DoM. DMG = N - COt-Bu. Synthetic Application HetAtom - Based Pyridine DoM. DMG = N - COt-Bu. Synthetic Application

12. HetAtom-Based Pyridine DoM. DMG = F, Cl. “Catalytic” Metalation. 3-Formyl-2-halopyridines HetAtom-Based Pyridine DoM. DMG = F, Cl. “Catalytic” Metalation. 3-Formyl-2-halopyridines

13. HetAtom-Based Pyridine DoM. DMG = F, Cl. Methodological Results HetAtom-Based Pyridine DoM. DMG = F, Cl. Methodological Results

14. HetAtom-Based Pyridine DoM. DMG = I, F. Tandem DoM / Halogen Dance Reactions of Iodopyridines HetAtom-Based Pyridine DoM. DMG = I, F. Tandem DoM / Halogen Dance Reactions of Iodopyridines

15. HetAtom-Based Pyridine DoM. DMG = SO 2 NR 2, SO 2 N - R Methodology and Application HetAtom-Based Pyridine DoM. DMG = SO 2 NR 2, SO 2 N - R Methodology and Application

16. HetAtom-Based Quinoline DoM. DMG = OCONEt 2 Methodology HetAtom-Based Quinoline DoM. DMG = OCONEt 2 Methodology

17. HetAtom - Based Quinoline DoM. DMG = N - COt-Bu. Methodology HetAtom - Based Quinoline DoM. DMG = N - COt-Bu. Methodology

18. Diazine DoM. Pyrimidines, DMG = OMe. Methodology Diazine DoM. Pyrimidines, DMG = OMe. Methodology

19. Diazine DoM. Pyrimidines, DMG = Cl. Methodology and Synthetic Utility Diazine DoM. Pyrimidines, DMG = Cl. Methodology and Synthetic Utility

20. Diazine DoM. Application to Nucleosides Diazine DoMDoM. Application to Nucleosides

21. Diazine DoM. Pyridazines, DMG = Cl. Methodology Diazine DoM. Pyridazines, DMG = Cl. Methodology

22. Diazine DoM. Pyridazines, DMG = Cl. Addition of s- and n-BuLi Diazine DoM. Pyridazines, DMG = Cl. Addition of s- and n-BuLi

23. Diazine DoM. Pyrazines, DMG = CON - t-Bu, N - COt-Bu Unusual Reactivity Diazine DoM. Pyrazines, DMG = CON - t-Bu, N - COt-Bu Unusual Reactivity

24. "I thought you said it was spot to spot."