2 Bone Functions Support Protection Assistance in movement Mineral storage and releaseBlood cell productionTriglyceride storage
3 Bone Chemistry Water (25%) Organic Constituent (~25%) Collagen.A fibrous protein that provide flexibility.Inorganic Constituent (~50%)Calcium phosphate and calcium carbonate.Mineral salts that provide hardness.
4 Bone Cell Types Osteogenic cells- stem cells. Osteoblasts- bone building cells, secrete matrix & collagen fibers.Osteocytes- mature bone cells that no longer secrete matrix.Osteoclasts- bone digestion.
5 Compact and Spongy Bone 80%20%Compact and Spongy Bone
6 Compact Bone- the osteon is the basic unit of structure.
7 Histology of Compact Bone Concentric Lamellae- calcified matrix surrounding a vertically oriented blood vessel.Lacuna- a small hollow space, contains osteocytes.Canaliculus- a small channel filled with extracellular fluid that connects lacunae to each other, and to the central canal.Central Canal- a circular channel that contains blood and lymphatic vessels, and nerves.
9 Spongy Bone Trabeculae- latticework of thin plates of bone. Spaces in between the lattice are filled with red marrow, which is where blood cells and platelets develop.Location- found near ends of long bones and inside flat bones. i.e. hipbones, sternum, sides of skull, and ribs.Histology- no true osteons.
11 Bone Growth in Length Epiphyseal plate Cartilage cells in this plate divide rapidly.Zone of proliferating cartilage.Between ages 18-25, the epiphyseal plates close.Cartilage cells in the plate stop dividing and bone replaces the cartilage.Growth in length stops at age 25.
13 Factors Affecting Bone Growth 1 NutritionAdequate levels of vitamins and minerals.Calcium and phosphorus for bone growth.Vitamin C for collagen formation.Vitamins K and B12 for protein synthesis.
14 Factors Affecting Bone Growth 2 HormonesDuring childhood growth factors stimulate cell division.Human growth hormone (hGH)Thyroid hormonesInsulinSex steroids at puberty initiate male and female characteristics.
15 Hormonal Abnormalities Oversecretion of hGH during childhood produces giantism.Undersecretion of hGH or the thyroid hormones during childhood produces dwarfism.The epiphyseal plate closes before normal height is reached.Estrogen is responsible for closing the growth plate.Both men and women that lack estrogen receptors on cells grow taller than normal.
16 Bone RemodelingBone Remodeling- the ongoing replacement of old bone tissue by new bone tissue.Resorption and DepositionOsteoclasts- removal of minerals and collagen.4% per year in compact bone.20% per year in spongy bone.Osteoblasts- deposition of minerals and collagen.
17 Aging and Bone Tissue Demineralization- loss of minerals. Very rapid in women as estrogen levels decrease.In males, begins after age 60, but is gradual.Decrease in protein synthesisDecrease in growth hormone.Decrease in collagen production, which gives bone its tensile strength, this causes bone to become brittle and susceptible to fracture.
18 Cold spots indicate Decreased metabolism of decalcified bone. Fracture.Infection.
19 Osteoporosis Decreased bone mass resulting in porous bones. Those at riskWhite, thin, menopausal, smoking, drinking females with a family history.Athletes who are not menstruating due to reduced body fat and decreased estrogen levels.People allergic to milk or with eating disorders whose intake of calcium is low.Prevention or decrease in severity of osteoporosis.Adequate diet, weight-bearing exercise, and estrogen replacement therapy (for menopausal women).Behavior when young may be most important factor.
20 Exercise and Bone Tissue Mechanical Stress- the pull on bone by skeletal muscle and gravity.Mechanical stress increases deposition of mineral salts and collagen production.
21 Lack of Mechanical Stress Results in Bone Loss.
23 Fracture- any break in a bone. Named for shape or position of fracture line.Common fracture types:Open fracture- skin broken.Comminuted- broken ends of bones are fragmented.Greenstick- partial fracture.Impacted- one side of fracture driven into the interior of other side.Pott’s- distal fibular fracture.Colles’- distal radial fracture.Stress fracture- microscopic fissures from repeated strenuous activities.
24 Developmental Anatomy Bone- derived from the Mesoderm germ layer.5th Week= limb bud appears as mesoderm covered with ectoderm.6th Week= constriction produces hand or foot plate, skeleton now totally cartilaginous.7th Week= endochondral ossification begins.8th Week= upper & lower limbs visible.
25 Joints Joint- a point of contact between Two bonesBone and cartilageBone and teethJoint= articulation=arthrosis.Arthrology- the scientific study of joints.Synovial Cavity- the space between articulating bones.
26 Classification of Joints Structural classification based upon:1) Type of connective tissue holding bones together.2) Presence or absence of space between bones.Fibrous joint- collagen fibers, no space.Cartilaginous joint- cartilage, no space.Synovial joint- dense irregular connective tissue, space.Functional classification based upon movement:Synarthrosis- immovable.Amphiarthrosis- slightly movable.Diarthrosis- freely movable.
28 Hinge JointConvex surface of one bone fits into concave surface of 2nd bone.Monoaxial movement, like a door hinge.Movements-Flexion- decreasing the joint angle.Extension- increasing the angle.Hyperextension- opening the joint beyond the anatomical position.ExamplesKnee, elbow, ankle, interphalangeal joints.