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1 © 2011 imec, K.U.Leuven and VIB INTRODUCTION TO The Centre for Neuro-Electronic Research Flanders Bart De Moor
2 © 2011 imec, K.U.Leuven and VIB THE HUMAN BRAIN 10 12 cells 25.000 connections / cell ! 10 16 connections ! how do they talk to each other link with behavior
3 © 2011 imec, K.U.Leuven and VIB CURRENT STRATEGIES molecular biol genetics cell biol dev biol small animal models omics approaches comput. biol. single electron transistors μ /n-scale solid state devices high density arrays electronic recording implantable wireless devices real time data encoding nanoparticles biological questionsbrain-computer interface NERF electrophysiology life imaging image processing clinical research
4 © 2011 imec, K.U.Leuven and VIB EMPOWERMENT OF NERF
5 © 2011 imec, K.U.Leuven and VIB KEY ATTRIBUTES VIB Molecular mechanisms and systems of living organisms non-profit organization partnerschip with 4 Flemish universities established by the Fl Gov’t in 1995 international environment (> 60 nat) 2012 research budget 90 M€ staff: 1250
6 © 2011 imec, K.U.Leuven and VIB KEY ATTRIBUTES IMEC non-profit organization independent established by the Fl Gov’t in 1984 worldwide reach (> 600 partners) 2012 research budget 300 M€ staff: 1870
7 © 2011 imec, K.U.Leuven and VIB KEY ATTRIBUTES KU LEUVEN prominent research oriented university established in 1425 6.000 researchers (120 countries) Ba – Ma: 35.000 students Doctoral schools: 3.500 Ph.D. -students univ hospital: Strong Med School
8 © 2011 imec, K.U.Leuven and VIB NERF: SCIENTIFIC AMBITION develop technologies to measure single cell activity single circuit activity coordinated activity interface solid state μ /n-scale devices with biological entities multidisciplinary approaches signal measurement live imaging behavior Qn map of neuronal circuit formation / function in vivo
9 © 2011 imec, K.U.Leuven and VIB NERF: STRATEGIC PLAN content focus neuronal network in vivo projects vs centre physical integration / multidisciplinary teams dedicated research groups 100% NERF critical mass lower limit: 50 p / 5 small groups long term: 10 years
10 © 2011 imec, K.U.Leuven and VIB NERF: STRATEGIC PLAN NERF-core: 50 p = 5-6 M€ / Y structural funding 50% commitment 3 partners 650 K€ / Y for 10 years extra leverage Flemish government: 1.75 M€ / Y support for NERF-core expertise imec – VIB – KU Leuven infrastructure imec – VIB – KU Leuven Financial plan
11 © 2011 imec, K.U.Leuven and VIB NERF: LOCATION – INTEGRATION: NEEDS 800 m² net space (imec) small animalarium on site access to imec-research infrastructure clean room design – processing – IC testing -... access to VIB-research infrastructure core / service facilities VIB technology platform access to infrastructure partner univs integration with LS and µe community
NERF: TIMING ACTION PLAN 200820092010201120122013 launch concept benchmark partners concept approval SAB content fine tuning PI3 hired PI4 hired midterm review start second cycle PI2 hired PI1 hired kick off event SAB govt support PI5 hired
13 © 2011 imec, K.U.Leuven and VIB HIGH LEVEL RECRUITMENT Emre Yaksi (HMS – Rachel Wilson) Vincent Bonin (HMS – Clay Reid) Fabian Kloosterman (MIT – Mat Willson) Bruce McNaughton (Univ Lethbridge, Canada) Francesco Battaglia ( Swammerdam Inst, NL) Staf Borghs (Sr Fellow, imec)
NERF GOUP LEADERS 2012 Emre Yaksi lab Neuronal circuits Processing of sensory information NERF PI Vincent Bonin lab Neuronal circuits Visual processing in mammalian brain NERF PI Fabian Kloosterman lab Memory circuits High density electrode arrays NERF PI
NERF VISITING SCIENTISTS 2012 Bruce McNaughton Neuronal ensemble recording technologies Episodic and spatial memory NERF visiting scientist Francesco Battaglia Neuronal circuits Mechanisms of learning & memory NERF visiting scientist
16 © 2011 imec, K.U.Leuven and VIB NERF COORDINATOR 2012 Staf Borghs Senior Fellow @ imec facilitating start up of NERF untill 2013
17 © 2011 imec, K.U.Leuven and VIB NERF STRUCTURE: ORGANIGRAM NERF Board NERF Director PI4PI5 Visiting scientist PI3 PI2PI1 NERF support SAB MC
18 © 2011 imec, K.U.Leuven and VIB NERF STRUCTURE VIB Jo Bury, managing director Rudy Dekeyser, managing director imec Ludo Deferm, VP Bus Dev Jo De Boeck, Senior VP Systems and Tech KU Leuven Peter Marynen, vice rector research Paul Van Dun, director LRD NERF board
19 © 2011 imec, K.U.Leuven and VIB NERF STRUCTURE no legal entity centre of excellence empowered by VIB, imec, K.U.Leuven located at imec campus strategic basic research scientific independance SAB
20 © 2011 imec, K.U.Leuven and VIB NERF: SAB Christof Koch – CalTech (Pasadena, US) Karel Svoboda – Jamelia Farm ( Ashburn, US) Stephen DeWeerth – GeorgiaTech (At, US) Gilles Laurent – MPI (Frankfurt, DE) Patrick Wolf – Duke Univ (Durham, US) Liqun Luo – Stanford Univ (Stanford, US)
21 © 2011 imec, K.U.Leuven and VIB NERF STRUCTURE SAB
22 © 2011 imec, K.U.Leuven and VIB HIGH LEVEL INFRASTRUCTURE
23 © 2011 imec, K.U.Leuven and VIB MODEL SYSTEMS
24 © 2011 imec, K.U.Leuven and VIB NERF ENVIRONMENT 200 mm Si Wafer clean room chip design (probes, sensors, actuators, MEMS,...) architectural optimization IC processing, testing Sub 32 nm CMOS technology 300 mm Si Wafer technology wireless communication electronic workshop mechanical workshop imec core facilities
25 © 2011 imec, K.U.Leuven and VIB INTRODUCTION TO The Centre for Neuro-Electronic Research Flanders Bart De Moor
© imec IMEC and its DESICS division. © imec Personnel (1999): ± 850 people 30,000 m 2 facilities, incl. 6000m 2 ultra clean processing area.
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