Presentation is loading. Please wait.

Presentation is loading. Please wait.

Salicylic Acid Semisolid Preparations Faith White Advisors: Dr. Antoine Al-Achi & Mrs. Janice Jackson-Freeman.

Similar presentations


Presentation on theme: "Salicylic Acid Semisolid Preparations Faith White Advisors: Dr. Antoine Al-Achi & Mrs. Janice Jackson-Freeman."— Presentation transcript:

1 Salicylic Acid Semisolid Preparations Faith White Advisors: Dr. Antoine Al-Achi & Mrs. Janice Jackson-Freeman

2 Objective The purpose of this experiment was to determine the distribution of salicylic acid in creams, ointments, and pastes.

3 Key Terms Salicylic Acid Cream Ointment Paste

4 Salicylic Acid (C 7 H 6 O 3 ) Salicylic acid is a fine, white powder. It is used externally on the skin. It helps in the treatment of athlete’s foot, ringworm of the scalp, and the removal of warts, corns, and calluses. Salicylic acid is also incorporated into preparations for the treatment of acne, dandruff, seborrhea, and insect bites. COOH OH

5 Cream Viscous liquid or semisolid emulsions of either the oil/water(o/w) or water/oil (w/o) type. Examples: O/W type:shaving, hand, and foundation creams W/O type: cold and emollient creams

6 Methods 1. Preparation of Cream Ingredient Ingredient weight(g) or amount(mL) with Salicylic Acid Ingredient weight (g) or amount (mL) without Salicylic Acid Water*19mL White Wax (beeswax)+12g Spermaceti Wax+12.5g Mineral Oil+54g56g Sodium Borate*.5g Salicylic Acid2g0g *Dissolve together using a steam bath till at the temperature of 70 o C remove from heat, then immediately add salicylic acid. +Dissolve together using a steam bath till at the temperature of 70 o C. -After both mixtures are at appropriate temperatures add together stirring rapidly and continuously until it has congealed.

7 Ointment Semisolid preparations intended for the external application to the skin or mucous membranes; usually contain medicinal substances; properties vary.

8 Methods 2.Preparation of Ointment IngredientIngredient weight (g) or amount (mL) with Salicylic Acid Ingredient weight (g) or amount (mL) without Salicylic Acid ^Sodium Lauryl Sulfate1g ^Propylene Glycol12g #Stearyl alcohol25g #White Petrolatum25g ^Methylparaben0.025g ^Propylparaben0.015g ^water33mL35mL Salicylic Acid2g0g ^Dissolve together using a steam bath till at the temperature of 75 o C remove from heat, then immediately add salicylic acid #Dissolve together using a steam bath till at the temperature of 75 o C. -after both mixtures are at the appropriate temperatures add together stirring rapidly and continuously until it has congealed.

9 Paste Concentrates of absorptive powders dispersed (usually) in petrolatum or hydrophilic petrolatum. Often used in the treatment of oozing lesions. Are also used to restrict the area of treatment by acting as an absorbent.

10 Methods 3.Preparation of Paste IngredientIngredient weight (g) with Salicylic acid Ingredient weight (g) without salicylic acid #Zinc Oxide25g #Starch25g White Petrolatum48g50g Salicylic Acid2g0g #Mix the ingredients together in a mortar and pestle, then add salicylic acid to mixture and then mix in the white petrolatum.

11

12 Preparation of Diluted Alcohol 515 mL of 95% ethyl alcohol USP was measured using volumetric flask and graduated cylinder. 500 mL of deionized water was measured using volumetric flask. Ethyl alcohol and deionized water was combined for a 49% alcohol solution.

13 Preparation of 0.1 N Sodium Hydroxide 8 grams of sodium hydroxide pellets was weighed and dissolved in deionized water and filled to 2 L mark on volumetric flask.

14 Methods a. To 25 mL of diluted alcohol (49%), one drop of phenolphthalein TS and sufficient 0.1 N sodium hydroxide from a buret was used to produce a faint pink color.

15 b. Five grams from one preparation was added and mixed for five minutes at 300 rpms on a stir plate. Methods

16 c. After the five minutes was up, the liquid in the flask was clear or white. Methods

17 d. Drops of 0.1 N sodium hydroxide from a buret was added to the flask slowly till a faint pink color developed. Methods

18 e. The amount of 0.1 N sodium hydroxide used was recorded to determine the precision. Methods

19 Amount of Salicylic Acid in Dosage Forms Each mL of 0.1 N sodium hydroxide is equivalent to mg of salicylic acid.

20 Results 5. The precision of our preparations. PreparationPrecision Cream45.3% Ointment38.4% Paste32.6 %

21 Conclusion Due to inconsistencies in the data it was concluded that maybe there was not sufficient mixing time for the release of salicylic acid from the base...

22 or maybe it was because I couldn’t stop eating the paste!!

23 Acknowledgements I would like to thank Dr. Al-Achi for all of his help in completing this experiment and Mrs. Freeman for all of her guidance, time, and patience.


Download ppt "Salicylic Acid Semisolid Preparations Faith White Advisors: Dr. Antoine Al-Achi & Mrs. Janice Jackson-Freeman."

Similar presentations


Ads by Google