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An efficient pipeline from medical images to numerical simulations Tiziano Passerini, PhD Department of Mathematics and Computer Science Emory University.

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Presentation on theme: "An efficient pipeline from medical images to numerical simulations Tiziano Passerini, PhD Department of Mathematics and Computer Science Emory University."— Presentation transcript:

1 An efficient pipeline from medical images to numerical simulations Tiziano Passerini, PhD Department of Mathematics and Computer Science Emory University Tiziano Passerini, PhD Department of Mathematics and Computer Science Emory University Acknowledgements: Support from Emory School of Medicine (Dr. W.R.Taylor, Dr. H.Samady) Support from Emory’s Strategic Initiative “Computational & Life Sciences” Support from The Brain Aneurysm Foundation (PI: Dr. A.Veneziani) Acknowledgements: Support from Emory School of Medicine (Dr. W.R.Taylor, Dr. H.Samady) Support from Emory’s Strategic Initiative “Computational & Life Sciences” Support from The Brain Aneurysm Foundation (PI: Dr. A.Veneziani) Mathematical models Geometrical multiscale models for the cardiovascular system; Reduced models for the dynamics of vascular networks. Publications: Alastruey, Passerini, Formaggia, Peiró, “PhysicalAlastruey, Passerini, Formaggia, Peiró, “Physical determinants of the arterial pulse waveform: determinants of the arterial pulse waveform: theoretical analysis and calculation using the 1-D theoretical analysis and calculation using the 1-D formulation”, J Eng Math, formulation”, J Eng Math, Passerini, De Luca, Formaggia, Quarteroni, Veneziani, “A 3D/1D geometrical multiscale model of cerebral vasculature”, J Eng Math, 2009.Passerini, De Luca, Formaggia, Quarteroni, Veneziani, “A 3D/1D geometrical multiscale model of cerebral vasculature”, J Eng Math, Partners: Dr. P.Blanco (LNCC, Brazil), Dr. L.Grinberg (Brown University), M.Piccinelli (Emory Radiology), Dr. A.Veneziani (Emory Math&CS). Mathematical models Geometrical multiscale models for the cardiovascular system; Reduced models for the dynamics of vascular networks. Publications: Alastruey, Passerini, Formaggia, Peiró, “PhysicalAlastruey, Passerini, Formaggia, Peiró, “Physical determinants of the arterial pulse waveform: determinants of the arterial pulse waveform: theoretical analysis and calculation using the 1-D theoretical analysis and calculation using the 1-D formulation”, J Eng Math, formulation”, J Eng Math, Passerini, De Luca, Formaggia, Quarteroni, Veneziani, “A 3D/1D geometrical multiscale model of cerebral vasculature”, J Eng Math, 2009.Passerini, De Luca, Formaggia, Quarteroni, Veneziani, “A 3D/1D geometrical multiscale model of cerebral vasculature”, J Eng Math, Partners: Dr. P.Blanco (LNCC, Brazil), Dr. L.Grinberg (Brown University), M.Piccinelli (Emory Radiology), Dr. A.Veneziani (Emory Math&CS). Pressure dynamics in the human physiological right arm, modeled by means of a 1D blood flow model. Numerical solver based on the LifeV library. Geometry and model parameters courtesy of Dr. P. Blanco. Pressure dynamics in the human physiological right arm, modeled by means of a 1D blood flow model. Numerical solver based on the LifeV library. Geometry and model parameters courtesy of Dr. P. Blanco. (m/s) Numerical methods Flow in a cylindrical nozzle with conical collector and sudden expansion. Reynolds number in the throat: Direct numerical simulation with second order tetrahedral finite elements. Mesh refinement based on the nozzle diameter. Flow in a cylindrical nozzle with conical collector and sudden expansion. Reynolds number in the throat: Direct numerical simulation with second order tetrahedral finite elements. Mesh refinement based on the nozzle diameter. Verification and validation of the CFD methodology. Ongoing project: FDA’s benchmark (Computational Round Robin #1: Nozzle) Partners: U.Villa, Dr. A.Veneziani (Emory Math&CS); Dr. A.Quaini, Dr. S.Canic (U Houston) Verification and validation of the CFD methodology. Ongoing project: FDA’s benchmark (Computational Round Robin #1: Nozzle) Partners: U.Villa, Dr. A.Veneziani (Emory Math&CS); Dr. A.Quaini, Dr. S.Canic (U Houston) Testing of hypotheses / Device design Parametric study on the positioning of the cannula in left ventricular assist device (LVAD) patients, and its effects on blood features. Partners: Dr. A.Veneziani (Emory Math&CS), M.Piccinelli (Emory Radiology); Dr. D.Gupta (Emory Cardiology) Parametric study on the positioning of the cannula in left ventricular assist device (LVAD) patients, and its effects on blood features. Partners: Dr. A.Veneziani (Emory Math&CS), M.Piccinelli (Emory Radiology); Dr. D.Gupta (Emory Cardiology) Velocity streamlines at the systolic peak in baseline conditions and in two different simulated post- surgical scenarios. The flow distribution in the sovra-aortic branches and flow stagnation at the aortic valve are sensitive to the cannula placement. OSI (healthy, simulated amputation OSI (difference, Amputation - Baseline OSI (healthy, baseline proximal distal Sensitivity analysis of blood flow patterns to local morphological features (angle between bifurcating arteries) and systemic conditions (increased peripheral resistances). Partners: A.Smolensky, Dr. W.R.Taylor (Emory Cardiology); M.Piccinelli, Dr. J.Oshinski (Emory Radiology); Dr. A.Veneziani (Emory Math&CS) Sensitivity analysis of blood flow patterns to local morphological features (angle between bifurcating arteries) and systemic conditions (increased peripheral resistances). Partners: A.Smolensky, Dr. W.R.Taylor (Emory Cardiology); M.Piccinelli, Dr. J.Oshinski (Emory Radiology); Dr. A.Veneziani (Emory Math&CS) Oscillatory shear index on the wall of the infrarenal aorta of a healthy subject in baseline conditions and after simulated left above knee amputation (inflation of a pressure cuff at the left thigh). OSI increases on the frontal and left sides of the distal arterial wall, suggesting a possible flow-induced localization of vascular diseases (e.g. aortic abdominal aneurysm). Image segmentation and morphological analysis Image segmentation and morphological analysis Patient data (medical images, diagnostics…) Patient data (medical images, diagnostics…) Mathematical models & analysis Computer simulations DatabaseDatabase Numerical methods Data mining knowledge extraction Data mining knowledge extraction Hypothesi s Database Store, classify, query large and complex data sets. Project: AneuriskWeb (ecm2.mathcs.emory.edu/aneuriskweb), a public, free repository of medical images, vascular geometries, hemodynamics simulations. The database can be browsed or queried based on geometric and hemodynamic features. Partners: M.Piccinelli (Emory Radiology), Dr. L.Antiga (Orobix), Dr. A.Veneziani (Emory Math&CS) Database Store, classify, query large and complex data sets. Project: AneuriskWeb (ecm2.mathcs.emory.edu/aneuriskweb), a public, free repository of medical images, vascular geometries, hemodynamics simulations. The database can be browsed or queried based on geometric and hemodynamic features. Partners: M.Piccinelli (Emory Radiology), Dr. L.Antiga (Orobix), Dr. A.Veneziani (Emory Math&CS) Sample data from the database. Velocity streamlines in a giant aneurysm of the internal carotid artery. In red: the aneurysm neck. Sample data from the database. Velocity streamlines in a giant aneurysm of the internal carotid artery. In red: the aneurysm neck. Partners: M.Piccinelli (Emory Radiology); M.Corban, Dr. H.Samady (Emory Cardiology); Dr. A.Veneziani (Emory Math&CS); Dr. L.Timmins, Dr. D.Giddens (Georgia Tech) Partners: In patients with left coronary artery disease, arterial segments with endothelial dysfunction (ED) show significantly lower time average wall shear stress (TAWSS) with respect to those with normal endothelial function. A sign of ED is a reduced radius after acetylcholine injection. Find fluid dynamics parameters that can be predictors of pathological events: study the wall shear stress as a marker of endothelial dysfunction in the coronary circulation. Post treatment Pre treatment Radius (mm) TAWSS (dyn/cm 2 )


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