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Information Management The old fashioned way! Gary R. Skuse, Ph.D. Director of Bioinformatics

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Presentation on theme: "Information Management The old fashioned way! Gary R. Skuse, Ph.D. Director of Bioinformatics"— Presentation transcript:

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2 Information Management The old fashioned way! Gary R. Skuse, Ph.D. Director of Bioinformatics

3 Essential Cell Biology : An Introduction to the Molecular Biology of the Cell by Bruce Alberts, Dennis Bray, Alexander Johnson, Julian Lewis, Peter Walter, Keith Roberts, Martin Raff Garland Pub; ISBN: All Illustrations taken from:

4 Molecular Biology is about Information Alice

5 Information Flow within Cells

6 Spatial Flow of Information

7 DNA is Organized into Chromosomes

8 Painted Chromosomes

9 Electron Micrographs of Chromosomes

10 Chromosomes are Comprised of DNA Packaged with Proteins

11 Chromosomes Contain Large Quantities of DNA

12 DNA can Replicate Itself

13 DNA Replication is Uncommonly Accurate

14 Information in DNA is Transcribed into RNA

15 There are Different Types of RNA

16 Gene Organization in Prokaryotes

17 Translation of Prokaryotic and Eukaryotic RNA

18 DNA Serves as a Template for Transcription

19 Eukaryotic Genes are Not Contiguous

20 RNA Splicing is Sequence Directed

21 Alternative Splicing Leads to Multiple Proteins from One Gene

22 RNA Processing, Like All Things Biological, is Complex

23 Gene Expression is Regulated Differently for Different Genes

24 RNA is Translated into Protein

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26 The Code Must be Parsed Accurately

27 Linear Strings of Amino Acids Interact

28 Proteins Fold to Form 3-D Structures

29 We can Depict Protein Structures in Many Ways

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33 Protein Shape Leads to Function

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35 Proteins may Change Shape as they Function

36 Genes are Somewhat Modular

37 Protein Structure Reflects that Modularity

38 Preparation of DNA for Cloning

39 Cloning of DNA

40 The PCR


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