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A Pilot Study of PLX3397, a Selective Colony-Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitor, in Pigmented Villonodular Synovitis (PVNS) Presented.

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Presentation on theme: "A Pilot Study of PLX3397, a Selective Colony-Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitor, in Pigmented Villonodular Synovitis (PVNS) Presented."— Presentation transcript:

1 A Pilot Study of PLX3397, a Selective Colony-Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitor, in Pigmented Villonodular Synovitis (PVNS) Presented By William Tap at 2014 ASCO Annual Meeting

2 Pigmented Villonodular Synovitis (PVNS) Tenosynovial Giant Cell Tumor (TGCT) Presented By William Tap at 2014 ASCO Annual Meeting

3 Pigmented Villonodular Synovitis (PVNS) Presented By William Tap at 2014 ASCO Annual Meeting

4 Slide 4 Presented By William Tap at 2014 ASCO Annual Meeting

5 Can we help patients (PVNS) with a highly targeted therapy (PLX3397) that blocks the CSF1R pathway in this clonal neoplastic process frequently initiated by a single genetic event? Presented By William Tap at 2014 ASCO Annual Meeting

6 Study Goals Presented By William Tap at 2014 ASCO Annual Meeting

7 Study Design Presented By William Tap at 2014 ASCO Annual Meeting

8 Efficacy Assessments Presented By William Tap at 2014 ASCO Annual Meeting

9 Tumor Volume Score (TVS) Presented By William Tap at 2014 ASCO Annual Meeting

10 Patient Disposition Presented By William Tap at 2014 ASCO Annual Meeting

11 Patient Characteristics: Safety Population (n=23) Presented By William Tap at 2014 ASCO Annual Meeting

12 Safety: PVNS Expansion Cohort AEs n = 23 Safety Population Presented By William Tap at 2014 ASCO Annual Meeting

13 Treatment-Related AEs ≥ Grade 3 Presented By William Tap at 2014 ASCO Annual Meeting

14 Duration of Treatment (DOT), April 2014 data cutoff: Median 256 days (range days) Presented By William Tap at 2014 ASCO Annual Meeting

15 14 patients evaluable with TVS Presented By William Tap at 2014 ASCO Annual Meeting

16 Slide 16 Presented By William Tap at 2014 ASCO Annual Meeting

17 Slide 17 Presented By William Tap at 2014 ASCO Annual Meeting

18 Slide 18 Presented By William Tap at 2014 ASCO Annual Meeting

19 Slide 19 Presented By William Tap at 2014 ASCO Annual Meeting

20 Slide 20 Presented By William Tap at 2014 ASCO Annual Meeting

21 Slide 21 Presented By William Tap at 2014 ASCO Annual Meeting

22 Conclusions Presented By William Tap at 2014 ASCO Annual Meeting

23 Thank You Presented By William Tap at 2014 ASCO Annual Meeting


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