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© 2006 STEP Consortium Seeding the EuroPhysiome: a roadmap to the Virtual Physiological Human Marco Viceconti STEP CONSORTIUM
© 2006 STEP Consortium The problems Genetic research is producing less clinical impact than expected because the increasing knowledge on the genome is somehow disconnected with that of proteome and of the physiome The specialisation of western medicine, based on the subdivision of the body in sub-systems, makes difficult to tackle all diseases with a strong systemic component The society a medicine based on quantitative evidences, where every clinical decision can be explained by clear and logical arguments
© 2006 STEP Consortium An example: osteoporosis OP is becoming a pandemic It has a genetic component but it is also strongly modulated by the hormonal balance, the dietary regime, and the type of daily physical activity The best method to monitor OP (DXA) can predict retrospectively only 65% of the OP spontaneous fractures (tossing a coin would give 50%) Preliminary studies suggest that the use of a predictive models that integrate the organ and the tissue scales with metabolic and lifestyle factors can increase accuracy up to 85-95%
© 2006 STEP Consortium The human Puzzle The human body is like a jigsaw puzzle made of a trillion pieces Currently we are trying to understand the whole picture by looking at a single piece, or at a few closely interconnected pieces We do need a frame, within which we can finally start to place the pieces all together, and the glue that connects them The frame is not the whole picture, but it is the only way we might hope to see it one day
© 2006 STEP Consortium Paradigmatic Shift in Biomedical Research Complement Reductionism With Integrationism
© 2006 STEP Consortium Integration across …. Across sub-systems
© 2006 STEP Consortium Integration across …. Across dimensional scales Organism (7) OrganSystem(6 ) Organ (5) Tissue (4) Cell (3) Molecule (2) Atom (1) Across Temporal scales
© 2006 STEP Consortium Integration across …. Across Disciplines Medicine BioEngineering Biology
© 2006 STEP Consortium It is necessary … Accumulate and share observations –laboratory and clinical observation are accumulated and made accessible by all those who can use them to develop or to validate new hypotheses Interconnect knowledge –knowledge we have is formalised and interconnected to those others are developing on contiguous sub- systems, scales, domains Create a framework –This is possible only if we create a powerful framework of technology and methods We call it the Virtual Physiological Human
© 2006 STEP Consortium Virtual Physiological Human Descriptive –a framework within which observations made in the laboratories, in the hospitals, and in the field all over the world can be collected, catalogued, organised, shared and combined in any possible way
© 2006 STEP Consortium Virtual Physiological Human Integrative –a framework that allows experts to collaboratively analyse this observations and develop systemic hypotheses that involve the knowledge of multiple scientific disciplines
© 2006 STEP Consortium Virtual Physiological Human Predictive –a framework that makes possible to interconnect predictive models defined at different scales, with different methods, and with different levels of detail, into systemic networks that provide concretisation to those systemic hypotheses, and make it possible to verify their validity by comparison with other clinical or laboratory observations
© 2006 STEP Consortium EuroPhysiome: Scope The scope of the EuroPhysiome Initiative is to promote the development of the Virtual Physiological Human, a methodological and technological framework that will enable the investigation of the human body as a single complex system We claim that, given sufficient resources, the European Research System can develop in the next 10 years the Virtual Physiological Human
© 2006 STEP Consortium Seeding the EuroPhysiome: a roadmap to the Virtual Physiological Human STEP is developing this roadmap through a consensus process involving hundreds of experts and the representatives of clinical, industrial and societal stakeholders The Roadmap is a document that describes the research and technological development that Europe should follow to achieve the realisation of the Virtual Physiological Human
© 2006 STEP Consortium Towards the VPH: Phase #1 VPH-related projects in IST/e-health: –AneurIST (neurovascular pathology) –ImmunoGrid (immune system physiology) –LHDL (musculoskeletal system physiology) 2005 - 2010
© 2006 STEP Consortium Towards the VPH: Phase #2 Building the EuroPhysiome –STEP Action: consensus process to write the VPH research roadmap http://www.europhysiome.org –Biomed Town: Internet community reserved to the biomedical researchers http://www.biomedtown.org 2006 - 2007
© 2006 STEP Consortium Towards the VPH: Phase #3 VPH research in multiple FP7 programs –QoL (DGRes): System Biology: linking genome, proteome and physiome Predictive multiscale models of human pathophysiology Clinical applications of VPH models –IST (DGInfso): VPH Technology development Large scale infrastructures VPH Knowledge management Processing, simulation and visualisation 2007 - 2016
© 2006 STEP Consortium VPH: Economic Impact Strong impact on Body Industry: all industries developing products that interact with the human body –Pharma Industry –Medical device & technology industry –Automotive industry (vehicle safety and comfort) –Tools and workplace industry (ergonomics and safety) –Aerospace industry (effects of weightlessness on humans, extra-vehicle activity suites) –Defence industry (evaluation of biological damage of conventional weapons, armours and shields) –Sport and Leisure industry (equipment for leisure and for competition) –Entertainment industry (creation of digital characters)
© 2006 STEP Consortium VPH: Health Impact Rare diseases Systemic diseases (cancer, osteoporosis, cardiovascular, obesity, diabetes, etc.) Preventive medicine, nutrition and lifestyle Disabling diseases (whiplash, back pain, repeated injury syndromes, etc) Reduced risk in clinical trials
© 2006 STEP Consortium VPH: Policies Impact Towards a quantitative evidence-based medicine Personalised Healthcare (gender, age, etc.) Easier production of public health epidemiology studies Reduced animal experimentation Fighting the “re-invent the wheel” syndrome in research Increase the public visibility of research investments
© 2006 STEP Consortium Thank You! http://www.europhysiome.org
© 2006 STEP Consortium Toward the Virtual Physiological Human: a primer for Policy Makers STEP CONSORTIUM.
© 2006 STEP Consortium What is the Virtual Physiological Human? Marco Viceconti Istituti Ortopedici Rizzoli (IT) STEP Scientific Coordinator.
Virtual Physiological Human Short presentation of the ARGOS VPH Policy Brief Marco Viceconti Istituto Ortopedico Rizzoli, Italy 1.
© 2006 STEP Consortium Day 2: Tuesday 16 May Reporters’ summaries of the six parallel sessions –Appointed reporters will encapsulate the discussions.
Footer European Commission eHealth in FP7: The Virtual Physiological Human Joël bacquet Head of sector Health Infrastructure DG Information Society and.
© 2006 STEP Consortium Towards the EuroPhysiome roadmap STEP CONFERENCE#1 Hard Tissue Strand discussion Monday, May 15 th Fulvia Taddei.
Who benefits from integrative biomedical research? The socio-economic assessment method of VPHOP Dr. rer. pol. Rainer Thiel, empirica with Karl Stroetman,
ICT-Bio 2006 Report on Parallel Session 1 Multilevel Modelling and Simulation of Human Physiology and Disease Related Processes ‘The Virtual Physiological.
Systemic change by streamlined innovation: personalised medicine Novembre 8, 2013.
Biomedical Research. What is Biomedical Research Biomedical research is the area of science devoted to the study of the processes of life; prevention.
EHFG 7 October 2005 – Patient Safety & Research UK Presidency Workshop on Patient Safety, EHFG, Bad Hofgastein,7 September 2005 Kevin McCarthy, European.
1 of 1 E- Health in the European Union Dr. Andrzej Rys Director for Health and Risk Assessment DG SANCO European Commission OPEN DAYS 2009 Mobility in.
Aligning Policy Agendas The case of personalised care and cure for healthy and active ageing Setting the scene for the DG Regio and Flanders Smart Specialisation.
Integrated Biomedical Information for Better Health Workprogramme Call 4 IST Conference- Networking Session.
Dr. José M. Millán, PhD Deputy Director of CIBERER Universitary Hospital La Fe, Valencia, Spain Barriers and Challenges in Rare Diseases Research Centre.
Integrating the gender aspects in research and promoting the participation of women in Life Sciences, Genomics and Biotechnology for Health.
Public Health Preventive Medicine and Epidemiology Prof. Ashry Gad Mohammed MB, ChB. MPH, Dr P.H Prof. of Epidemiology College of Medicine King Saud University.
Horizon societal challenge 1 ICT for Health, demographic change and well-being – Work Programme Horizon 2020 Health, Demographic Change.
10 th October 2013 The delivery of 21 st century services – the implications for the evolution of the Healthcare Science workforce Joan Fletcher.
What is “Biomedical Informatics”?. Biomedical Informatics Biomedical informatics (BMI) is the interdisciplinary field that studies and pursues.
Collaboration in eRegion- ICT for Growth and Empowerment Bror Salmelin Head of Unit, New working environments European Commission, DG Information Society.
European Health Forum Gastein, Bad Hofgastein, Austria, September 2002 Towards the Sixth Framework Programme Parallel Forum V 26 September 2002 Public.
EF on IST in FP6 in Greece Information Day Athens-Thessaloniki, December 2002 The IST Priority in FP6 Erastos Filos
Clinical trials in Framework programme 7 (FP7) EU Judita Kinkorová 2. Národní konference o doporučených postupech, Olomouc 13. listopadu 2010.
National Information Day Greece 23 July 2015 Funding priorities under the work plan 2015.
NIHR Southampton Biomedical Research Centre The Southampton Biomedical Research Centre is funded by the National Institute for Health Research (NIHR) and.
Biomedical Informatics and Health. What is “Biomedical Informatics”?
Towards semantic interoperability solutions Dipak Kalra.
HeC PMT Meeting Tallinn 10 July 2008 Brainstorming session: what interest can there be in thinking about a possible new HeC 2 project to follow-up the.
Inquiry Based Science Education The ESTABLISH project has received funding from the European Union’s Seventh Framework Programme [FP7/ ] under.
SPHERE: Gastein Health Forum Research for the Citizens of Europe Science Europe Health Mark McCarthy Professor of Public Health University College London.
Biomedical Research Objective 2 Biomedical Research Methods.
© UEG Presentation by Towards more coordination in health research: a report on the UEG research symposium 16/11/2012 Michael Manns General Assembly.
EU eHealth Agenda Petra Wilson Director
Science Content Standards, Benchmarks, and Performance Standards 5 th -8 th Grade Strand I:Scientific Thinking and Practice Standard I:Understand the processes.
NICE and NICE’s equality programme in 2012 Nick Doyle Clinical and public health analyst.
Living with Climate Change Systemic investigation of climate change impacts on our society and efficient adaptation / mitigation scenarios to sustain our.
Delivering Global Goals in human settlements and city regions by 2030 with data partnerships #roadmap rd May 2016 WMO, Geneva Stephen Passmore Head.
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1 An initiative developed in the framework of the START project supported by the European Commission (DG InfSo) START IST SSA.
1 Biomedical Sciences Public and Environmental Health Regenerative Medicine Translational Research.
Information Society Technologies Information Society Technologies Workprogramme 2001 DG Information Society European Commission HEALTH Action Line I.1.1.
Heritage for All, Luxembourg 2-3 June 2003 Cultural Heritage and the 6 th Framework Programme Bernard Smith Head of Division Preservation and Enhancement.
Bachelor of Biomedical Science Department of Biological.
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