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Myoid Thymoma in F-344 Rats Neil Allison, DVM Diplomate ACVP Experimental Pathology Laboratories, Inc Presented at SEVPAC 2008 – Permission granted for.

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Presentation on theme: "Myoid Thymoma in F-344 Rats Neil Allison, DVM Diplomate ACVP Experimental Pathology Laboratories, Inc Presented at SEVPAC 2008 – Permission granted for."— Presentation transcript:

1 Myoid Thymoma in F-344 Rats Neil Allison, DVM Diplomate ACVP Experimental Pathology Laboratories, Inc Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

2 Signalment Rat, F-344 Female 1.5 year-old Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

3 History National Toxicology Program (NTP) chronic carcinogenesis study Thin, ataxic and breathing abnormally on day 526 of the study Euthanasia Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

4 Necropsy Findings Cranial mediastinal mass Discrete, oval, mottled 40 x 32 x 25 mm Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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15 Desmin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

16 Cytokeratin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

17 Diagnosis Myoid thymoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

18 Discussion Reviewed all thymomas in NTP Data from Approximately 189,500 F344 rats 4/244 thymomas with myoid component One myoid thymoma after 2003 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

19 Discussion Benign or malignant? Gross = Huge and discrete mass No invasion of viscera, diaphragm or body wall No Metastasis Cytology = Malignant Behavior = Benign Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

20 Discussion –Other Names Carcinosarcoma Sarcomatoid carcinoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

21 Acknowledgement Julie Foley Natasha Clayton Maureen Puccini Emily Singletary David Sabio Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

22 References 1. Snover MS, Levine GD, Rosai J: Thymic carcinoma. Five distinct histological variants. Am j Surg Pathol 6: , Rosai J, Sobin LH: Histological typing of tumours of the thymus. In: World Health Organisation, International Histological Classification of Tumours, 2 nd ed., pp Springer, Berlin, Germany, Henry K: An unusual tumour with a striated muscle (myoid) component (with a brief review of the literature on myoid cells). Brit J Dis Chest 66: , Murakami S, Shamoto M, Miura K, Takeuchi J: A thymic tumor with massive proliferation of myoid cells. Acta Pathol Jpn 34: , Pearse G: Histopathology of the thymus. Toxicol Pathol 34: , 2006 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


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