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CHAPTER 24 RESPIRATION. TYPES OF RESPIRATORY SYSTEMS Respiration is the uptake of oxygen and the simultaneous release of carbon dioxide. Most primitive.

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Presentation on theme: "CHAPTER 24 RESPIRATION. TYPES OF RESPIRATORY SYSTEMS Respiration is the uptake of oxygen and the simultaneous release of carbon dioxide. Most primitive."— Presentation transcript:

1 CHAPTER 24 RESPIRATION

2 TYPES OF RESPIRATORY SYSTEMS Respiration is the uptake of oxygen and the simultaneous release of carbon dioxide. Most primitive animal phyla obtain oxygen directly from their environments through diffusion. More advanced phyla have specific respiratory organs: Gills, tracheae, and lungs

3 GAS EXCHANGE IN ANIMALS Flatworm CO 2 O2O2 Body wall CO 2 Tracheoles Spiracles Trachea O2O2 O2O2 CO 2 Spiracle Terrestrial arthropod Gill filament Blood vessels Fish Gill CO 2 O2O2 O2O2 Trachea Mammalian lung Blood vessels Alveoli Mammal CO 2

4 RESPIRATION IN AQUATIC VERTEBRATES Water always moves past a fish’s gills in one direction. Gill raker Gill arch Gill rakerGill arch Water Gill filaments Lamellae with capillary networks Water Direction of water flow Direction of blood flow Vein Water Artery Water Gill filaments

5 RESPIRATION IN AQUATIC VERTEBRATES Moving the water past the gills in the same direction permits countercurrent flow. This process is an extremely efficient way of extracting oxygen. Blood flows through a gill filament in an opposite direction to the movement of water. The blood in the blood vessels always encounters water with a higher oxygen concentration, resulting in the diffusion of oxygen into the blood vessels.

6 RESPIRATION IN TERRESTRIAL VERTEBRATES Lungs are less efficient than gills because new air that is inhaled mixes with old air already in the lung. But there is so much more oxygen in air than in water.

7 RESPIRATION IN TERRESTRIAL VERTEBRATES The lungs of mammals possess on their inner surface many small chambers called alveoli, which greatly increases surface area for the diffusion of oxygen. (a) Amphibian(b )Reptile(c) Mammal Alveoli Bronchiole

8 RESPIRATION IN TERRESTRIAL VERTEBRATES Flying creates a respiratory demand for oxygen that exceeds the capacity of the saclike lungs of even the most active mammal. Birds have evolved the most efficient lung. An avian lung is connected to a series of air sacs outside of the lung.

9 RESPIRATION IN TERRESTRIAL VERTEBRATES This creates a unidirectional flow of air through the lungs. Blood flow and airflow are not opposite but flow at perpendicular angles in crosscurrent flow.

10 THE MAMMALIAN RESPIRATORY SYSTEM In the mammalian respiratory system, air passes in and out of the lungs, which are housed in the thoracic cavity. Air is warmed and filtered as it flows through the nasal cavity. It passes next through the pharynx, then the larynx (or voice box), then to the trachea, or windpipe. Nasal cavity Nostril Glottis Larynx Trachea Right lung Pharynx Epiglottis Left lung Left bronchus

11 THE MAMMALIAN RESPIRATORY SYSTEM From there, air passes through several branchings of bronchi in the lungs and then to the bronchioles. The tissue of the lungs is divided into tiny air sacs called alveoli; through these thin-walled cells, gas exchange with the blood occurs. Blood flow Smooth muscle Bronchiole Pulmonary arteriole Pulmonary venule Alveolar sac Alveoli Capillary network on surface of alveolus

12 THE MAMMALIAN RESPIRATORY SYSTEM The mammal respiratory apparatus is simple in structure and functions as a one-cycle pump. A diaphragm muscle separates the thoracic cavity from the abdominal cavity. Each lung is covered by a thin, smooth membrane called the pleural membrane. This membrane adheres to another pleural membrane lining the walls of the thoracic cavity, basically coupling the lungs to the thoracic cavity.

13 THE MAMMALIAN RESPIRATORY SYSTEM Air is drawn into the lungs by the creation of negative pressure. The active pumping of air in and out is called breathing. During inhalation, muscular contraction causes the chest cavity to expand. During exhalation, the ribs and diaphragm return to their original position.

14 KEY BIOLOGICAL PROCESS: BREATHING 14 < P lung >P air Before inhalation, the air pressure in the lungs (P lung ) is equal to the atmospheric pressure (P air ). During inhalation, the diaphragm contracts, and the chest cavity expands downward and outward. This increases the volume of the chest cavity and lungs, which reduces the air pressure inside the lungs, and the air from outside the body flows into the lungs. During exhalation, the diaphragm relaxes, decreasing the volume of the chest cavity. The pressure increases in the lungs, forcing air out of the lungs Diaphragm relaxed P lung P air Inhalation Chest cavity expands Diaphragm relaxed P lung Exhalation P air Diaphragm contracts P lung P air P lung P lung = P air

15 HOW RESPIRATION WORKS: GAS EXCHANGE Oxygen moves through the circulatory system carried by the protein hemoglobin. Hemoglobin molecules contain iron, which binds oxygen in a reversible way. Heme group Beta (β) chains Oxygen (O 2 ) Iron (Fe ++ ) Alpha (  ) chains

16 HOW RESPIRATION WORKS: GAS EXCHANGE Hemoglobin molecules act like little sponges for oxygen. At the high O 2 levels that occur in the blood supply at the lung, most hemoglobin molecules carry a full load of O 2. In the tissues, the O 2 levels are much lower, so hemoglobin gives up its bound oxygen. In the presence of CO 2, the hemoglobin assumes a different shape that gives up its oxygen more readily.

17 HOW RESPIRATION WORKS: GAS EXCHANGE CO 2 must also be transported by the blood. About 8% simply dissolves in the plasma. 20% is bound to hemoglobin but at a different site than where O 2 binds. The remaining 72% diffuses into the red blood cells. In order to maintain the gradient for CO 2 to leave the tissues and enter the plasma, the CO 2 levels in the plasma must be kept low.

18 HOW RESPIRATION WORKS: GAS EXCHANGE The enzyme carbonic anhydrase combines CO 2 with water to form carbonic acid (H 2 CO 3 ). This acid dissociates into bicarbonate (HCO 3 – ) and H +. Bicarbonate also acts as buffer in the blood plasma. In the lungs, the reverse reaction takes place, and CO 2 is released.

19 THE NATURE OF LUNG CANCER Lung cancer is one of the leading causes of death among adults. Mutations to two tumor-suppressing genes are implicated in the development of cancer. Rb codes for Rb protein, which acts as a brake on cell division. p53 codes for p53 protein, which detects damaged or foreign DNA and prevents its replication.

20 THE NATURE OF LUNG CANCER Smoking causes lung cancer. The annual incidence of lung cancer is much higher for smokers than for nonsmokers. Changes in the incidence of lung cancer have mirrored changes in smoking habits. Many types of mutagens are found in cigarette smoke that can damage genes. The p53 gene is damaged in 70% of lung cancers. Smoking also leads to nicotine addiction.

21 INCIDENCE OF LUNG CANCER IN MEN AND WOMEN 1 Per capita cigarette consumption Lung cancer death rates per 100,000 Per capita cigarette consumption Males Cigarette consumption 30years Lung cancer deaths Time Females Cigarette consumption 30years Lung cancer deaths Time


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