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Copyright © 2010 Pearson Education, Inc. Marieb Chapter 22: The Respiratory System Part A
Copyright © 2010 Pearson Education, Inc. Respiration Pulmonary ventilation (breathing): movement of air into and out of the lungs External respiration: O 2 and CO 2 exchange between the lungs and the blood Transport: O 2 and CO 2 in the blood Internal respiration: O 2 and CO 2 exchange between systemic blood vessels and tissues Respiratory system Circulatory system
Copyright © 2010 Pearson Education, Inc. Functional Anatomy Respiratory zone: site of gas exchange Microscopic structures: respiratory bronchioles, alveolar ducts, and alveoli Conducting zone: passageways to gas exchange sites Includes all other respiratory structures Respiratory muscles: diaphragm and other muscles that promote ventilation
Copyright © 2010 Pearson Education, Inc. Defense Mechanisms
Copyright © 2010 Pearson Education, Inc. Why Is The Lung Considered Sterile?
Copyright © 2010 Pearson Education, Inc. Bronchi and Subdivisions Air passages undergo 23 orders of branching Branching pattern called the bronchial (respiratory) tree
Copyright © 2010 Pearson Education, Inc. Respiratory Zone Respiratory bronchioles, alveolar ducts, alveolar sacs (clusters of alveoli) ~300 million alveoli account for most of the lungs’ volume and are the main site for gas exchange
Copyright © 2010 Pearson Education, Inc. Figure 22.8a (a) Alveolar duct Alveoli Alveolar sac Respiratory bronchioles Terminal bronchiole
Copyright © 2010 Pearson Education, Inc. Respiratory Membrane ~0.5- m-thick air-blood barrier Alveolar and capillary walls and their fused basement membranes Alveolar walls Single layer of squamous epithelium (type I cells) Scattered type II cuboidal cells secrete surfactant and antimicrobial proteins
Copyright © 2010 Pearson Education, Inc. Respiratory Membrane
Copyright © 2010 Pearson Education, Inc. Figure 22.9c Capillary Type II (surfactant- secreting) cell Type I cell of alveolar wall Endothelial cell nucleus Macrophage Alveoli (gas-filled air spaces) Red blood cell in capillary Alveolar pores Capillary endothelium Fused basement membranes of the alveolar epithelium and the capillary endothelium Alveolar epithelium Respiratory membrane Red blood cell O2O2 Alveolus CO 2 Capillary Alveolus Nucleus of type I (squamous epithelial) cell (c) Detailed anatomy of the respiratory membrane
Copyright © 2010 Pearson Education, Inc. Figure 22.9a Elastic fibers (a) Diagrammatic view of capillary-alveoli relationships Smooth muscle Alveolus Capillaries Terminal bronchiole Respiratory bronchiole
Copyright © 2010 Pearson Education, Inc. Alveoli Surrounded by fine elastic fibers Contain open pores that Connect adjacent alveoli Allow air pressure throughout the lung to be equalized House alveolar macrophages that keep alveolar surfaces sterile
Copyright © 2010 Pearson Education, Inc. Fluids And The Lung Pleural fluid fills the pleural cavity Provides lubrication and surface tension Surfactant within the alveoli Lowers alveolar surface tension
Copyright © 2010 Pearson Education, Inc. Mechanics of Breathing Pulmonary ventilation consists of two phases 1.Inspiration: gases flow into the lungs 2.Expiration: gases exit the lungs
Copyright © 2010 Pearson Education, Inc. Pressure Relationships in the Thoracic Cavity Atmospheric pressure (P atm ) Pressure exerted by the air surrounding the body 760 mm Hg at sea level Respiratory pressures are described relative to P atm Negative respiratory pressure is less than P atm Positive respiratory pressure is greater than P atm Zero respiratory pressure = P atm
Copyright © 2010 Pearson Education, Inc. Intrapulmonary Pressure Intrapulmonary (intra-alveolar) pressure (P pul ) Pressure in the alveoli Fluctuates with breathing Always eventually equalizes with P atm
Copyright © 2010 Pearson Education, Inc. Intrapleural Pressure Intrapleural pressure (P ip ): Pressure in the pleural cavity Fluctuates with breathing Always a negative pressure (
Copyright © 2010 Pearson Education, Inc. Intrapleural Pressure Negative P ip is caused by opposing forces Two inward forces promote lung collapse Elastic recoil of lungs decreases lung size Surface tension of alveolar fluid reduces alveolar size One outward force tends to enlarge the lungs Elasticity of the chest wall pulls the thorax outward
Copyright © 2010 Pearson Education, Inc. Alveolar Surface Tension Surfactant Detergent-like lipid and protein complex produced by type II alveolar cells Reduces surface tension of alveolar fluid and discourages alveolar collapse Insufficient quantity in premature infants causes infant respiratory distress syndrome
Copyright © 2010 Pearson Education, Inc. Figure Atmospheric pressure Intrapleural pressure 756 mm Hg (–4 mm Hg) Transpulmonary pressure 760 mm Hg –756 mm Hg = 4 mm Hg Thoracic wall Diaphragm Lung Intrapulmonary pressure 760 mm Hg (0 mm Hg) Parietal pleura Pleural cavity Visceral pleura
Copyright © 2010 Pearson Education, Inc. Homeostatic Imbalance Atelectasis (lung collapse) is due to Plugged bronchioles collapse of alveoli Wound that admits air into pleural cavity (pneumothorax)
Copyright © 2010 Pearson Education, Inc. Pulmonary Ventilation Inspiration and expiration Mechanical processes that depend on volume changes in the thoracic cavity Volume changes pressure changes Pressure changes gases flow to equalize pressure
Copyright © 2010 Pearson Education, Inc. Boyle’s Law The relationship between the pressure and volume of a gas Pressure (P) varies inversely with volume (V): P 1 V 1 = P 2 V 2
Copyright © 2010 Pearson Education, Inc. Inspiration An active process Inspiratory muscles contract Thoracic volume increases Lungs are stretched and intrapulmonary volume increases Intrapulmonary pressure drops (to 1 mm Hg) Air flows into the lungs, down its pressure gradient, until P pul = P atm
Copyright © 2010 Pearson Education, Inc. Figure (1 of 2) Sequence of events Changes in anterior- posterior and superior- inferior dimensions Changes in lateral dimensions (superior view) Ribs are elevated and sternum flares as external intercostals contract. Diaphragm moves inferiorly during contraction. External intercostals contract. Inspiratory muscles contract (diaphragm descends; rib cage rises). 2 1 Thoracic cavity volume increases. 3 Lungs are stretched; intrapulmonary volume increases. 4 Intrapulmonary pressure drops (to –1 mm Hg). 5 Air (gases) flows into lungs down its pressure gradient until intrapulmonary pressure is 0 (equal to atmospheric pressure).
Copyright © 2010 Pearson Education, Inc. Expiration Quiet expiration is normally a passive process Inspiratory muscles relax Thoracic cavity volume decreases Elastic lungs recoil and intrapulmonary volume decreases P pul rises (to +1 mm Hg) Air flows out of the lungs down its pressure gradient until Ppul = 0 Note: forced expiration is an active process: it uses abdominal and internal intercostal muscles
Copyright © 2010 Pearson Education, Inc. Figure (2 of 2) Sequence of events Changes in anterior- posterior and superior- inferior dimensions Changes in lateral dimensions (superior view) Ribs and sternum are depressed as external intercostals relax. External intercostals relax. Diaphragm moves superiorly as it relaxes. 1 Inspiratory muscles relax (diaphragm rises; rib cage descends due to recoil of costal cartilages). 2 Thoracic cavity volume decreases. 3 Elastic lungs recoil passively; intrapulmonary volume decreases. 4 Intrapulmonary pres- sure rises (to +1 mm Hg). 5 Air (gases) flows out of lungs down its pressure gradient until intra- pulmonary pressure is 0.
Copyright © 2010 Pearson Education, Inc. Figure seconds elapsed Volume of breath Intrapulmonary pressure Expiration Intrapleural pressure Trans- pulmonary pressure Inspiration Intrapulmonary pressure. Pressure inside lung decreases as lung volume increases during inspiration; pressure increases during expiration. Intrapleural pressure. Pleural cavity pressure becomes more negative as chest wall expands during inspiration. Returns to initial value as chest wall recoils. Volume of breath. During each breath, the pressure gradients move 0.5 liter of air into and out of the lungs.
Copyright © 2010 Pearson Education, Inc. Airway Resistance Resistance is usually not a problem for normal people because we have large diameter airways or many smaller diameter airways As airway resistance rises, breathing movements become more strenuous Severely constricting or obstruction of bronchioles Can prevent life-sustaining ventilation Can occur during acute asthma attacks and stop ventilation Epinephrine dilates bronchioles and reduces air resistance
Copyright © 2010 Pearson Education, Inc. Lung Compliance
Copyright © 2010 Pearson Education, Inc. Lung Compliance Lessened by Non-elastic scar tissue (fibrosis) Reduced production of surfactant Decreased flexibility of the thoracic cage
Overview of Respiration and Respiratory Mechanics Dr Shihab Khogali Ninewells Hospital & Medical School, University of Dundee.
23-1 Chapter 23 Respiratory System Respiration Ventilation: Movement of air into and out of lungs External respiration: Gas exchange between air.
ELAINE N. MARIEB EIGHTH EDITION 13 Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation by.
Copyright 2009, John Wiley & Sons, Inc. Chapter 23: The Respiratory System.
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Functions of the Respiratory system P6 M3. responsible The respiratory system is responsible for: – getting oxygen in to our body – Getting carbon dioxide.
© 2012 Pearson Education, Inc. Chapter 23 – The Respiratory System $100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 Structures of the Respiratory.
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Respiratory System Part II. Respiratory Physiology In order to supply the body with oxygen and get rid of carbon dioxide the process of respiration MUST.
22-1 Chapter 22 Lecture Outline See PowerPoint Image Slides for all figures and tables pre-inserted into PowerPoint without notes. Copyright (c) The McGraw-Hill.
UNIFYING CONCEPTS OF ANIMAL RESPIRATION Cells using cellular respiration need a steady supply of oxygen and must continuously dispose of CO 2 The respiratory.
I.Introduction A.Of all the substances the body must have to survive, oxygen is by far the most critical: 1.Without food – live a few weeks 2.Without.
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Respiratory System Take a big whiff!
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Click on a lesson name to select. Section 1: Circulatory System Section 2: Respiratory System Section 3: Excretory System Chapter 34 Circulatory, Respiratory,
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Respiratory System ROLE: To bring oxygen into the body and to get rid of the carbon dioxide from the body.
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