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Pulmonary Ventilation. Pulmonary Structure and Function Pulmonary Ventilation – Process by which ambient air is moved into and exchanges with air in the.

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Presentation on theme: "Pulmonary Ventilation. Pulmonary Structure and Function Pulmonary Ventilation – Process by which ambient air is moved into and exchanges with air in the."— Presentation transcript:

1 Pulmonary Ventilation

2 Pulmonary Structure and Function Pulmonary Ventilation – Process by which ambient air is moved into and exchanges with air in the lungs …Different from oxygen consumption Figure 12.1

3 Pulmonary Structure and Function Gas exchange (O 2 and CO 2 ) occurs in the alveoli O 2 transfers from alveolus to capillary blood CO 2 transfers from capillary blood to alveolus Fig 12.1 Each minute at rest 250 ml of O 2 and 200 ml of CO 2 diffuse in opposite directions

4 Pulmonary Structure and Function Fig 12.1 Lungs contain 600 million alveoli Extremely thin- walled sacs (0.3 mm thick) Lie side by side with thin walled capillaries Alveoli receive largest blood supply of any organ in the body

5 Pulmonary Structure and Function Lungs – Extremely large surface area for gas exchange Lungs provide the gas exchange surface separating blood from alveolar gases Figure 12.2 Adult lung weighs 1 kg and hold 4-6 L of air

6 Pulmonary Structure and Function Pulmonary ventilation functions primarily to maintain a constant and favorable concentration of O 2 and CO 2 in the alveoli during rest and exercise Adequate pulmonary ventilation ensures complete gas exchange before blood leaves lungs for transport to tissues

7 Pulmonary Structure and Function Breathing mechanics Inspiration – diaphragm descends, ribs are raised, volume increases, intrapulmonic pressure decreases, air rushes in (chest cavity size increases) Contributing muscles: external intercostals, sternocleidomastoids, scalenes, spinal extensors Fig 12.3

8 Pulmonary Structure and Function Breathing mechanics Expiration – Passive process diaphragm relaxes, ribs lower, volume decreases, intrapulmonic pressure increases, air rushes out (chest cavity size decreases) Contributing muscles: rectus abdominus, internal intercostals, posterior inferior serratus Fig 12.3

9 Pulmonary Structure and Function Ventilatory System: Conducting Zone – Trachea to Bronchioles No alveoli Air transport, warming, humidification, particle filtration Anatomic "Dead" Space *Respiratory Zone – Bronchioles to Alveoli Surface area for gas exchange Fig 12.4

10 Pulmonary Structure and Function Measuring Lung Volume: Lung volumes measurements (static or dynamic) can help identify potential obstructive or restrictive lung diseases Lung volumes vary with age, gender, body size, body composition and stature Fig 12.6 Water-sealed, volume displacement recording spirometer

11 Pulmonary Structure and Function Static Lung Volume Measurements: Provides record of ventilatory volume and breathing rate Tidal Volume (TV) – volume inspired or expired per breath (600 ml) Inspiratory Reserve Volume (IRV) – maximal inspiration at end of tidal inspiration (3000 ml) Expiratory Reserve Volume (ERV) – maximal expiration at end of tidal expiration (1200 ml) Force Vital Capacity (FVC) – maximal volume expired after maximal inspiration (TV+IRV+ERV; 4800 ml) Fig 12.6

12 Pulmonary Structure and Function Static Lung Volume Measurements: Residual Lung Volume (RLV) – air volume remaining in lungs after maximal expiration (1200 ml) -allows uninterrupted gas exchange between blood and alveoli Functional Residual Capacity (FRC) – Volume in lungs after tidal expiration (ERV + RLV; 2400 ml) Total Lung Capacity (TLC) – volume in lungs after maximal inspiration (FVC + RLV; 6000 ml) Fig 12.6

13 Pulmonary Structure and Function Dynamic Lung Volumes: Adequate pulmonary ventilation depends on ability to sustain high airflow levels (not air movement in single breath) Dynamic Ventilation depends on: 1)FVC (“stroke volume” of the lungs) 2)Breathing rate High airflow levels (velocity) depends on lung compliance (ability to stretch or expand) : “loose” (high compliance) – emphysema, asthma “stiff” (low compliance) – fibrosis

14 Pulmonary Structure and Function Dynamic Lung Volumes Forced Expiratory Volume (FEV) to FVC ratio: FVC measured over 1 s (FEV 1.0 ) – measures pulmonary airflow capacity, or overall resistance to air movement upstream in the lungs (normal value = 80-85% of FVC) Fig 12.8 No Elastic Recoil (loose) Too Much Elastic Recoil (stiff)

15 Pulmonary Structure and Function 3. Minute Ventilation (VE): Volume of air moved in and out of respiratory tract per minute VE=Breathing Rate (BR) x TV At restVE = 12 breaths/min x 0.5 L/breath VE = 6 L  min ExerciseVE = 30 x 2.5VE=50 x 3.5 VE = 75 L  minVE=150 L  min ModerateVigorous

16 Pulmonary Structure and Function Dynamic Lung Volumes: Measurements of dynamic lung function can indicate the severity of obstructive or restrictive lung diseases FEV/FVC - Normal or increased for restrictive lung disease (80% or greater) FEV/FVC - <70% indicates obstructive lung disease

17 Pulmonary Structure and Function Aging and lifestyle affect lung volumes and pulmonary function Aging: Decreased lung compliance FEV 1.0 and FVC decrease after age 20 Diffusion capacity decreases Partial Pressure of O 2 decreases Diaphragm muscles weakens by ~25%

18 Pulmonary Structure and Function Dynamic Lung Volumes: Provide no information about aerobic fitness: No difference in healthy vs olympic athletes Not predictive of track or marathon performance, distance running

19 Pulmonary Structure and Function Dynamic Lung Volumes: Important part of standard medical/health examination for “at risk” exercisers (smokers, asthmatics)

20 Pulmonary Structure and Function By increasing rate and depth of breathing - increases alveolar ventilation TV increases at start of moderate exercise As intensity increases, TV plateaus at 60% of FVC Breathing rate provides alveolar ventilation at higher exercise intensities How do we ensure sufficient air reaches the alveoli during exercise? Fig 12.10

21 Pulmonary Structure and Function Definitions: Hyperventilation – increase in pulmonary ventilation that exceeds the O 2 needs of metabolism (“overbreathing”) Unloads CO 2 excessively (which constricts arteries with less O 2 to brain) Can lead to unconsciousness.

22 Pulmonary Structure and Function Definitions: Dyspnea – shortness of breath or subjective distress in breathing (sense of inability to breathe) Occurs in physical exertion (novel exercisers), at altitude, or with obstructive or restrictive pulmonary disorders Result of elevated CO 2 and H + in blood from fatigue of poorly trained respiratory muscles (shallow, ineffective breathing)

23 Pulmonary Structure and Function Definitions: Valsalva Maneuver – Increases intrathoracic pressure that occurs when exhalation is forced against a closed glottis Results: Collapse of veins in thoracic region Impaired venous return Acute DROP in arterial blood pressure Decreased blood supply to brain "spots before the eyes" "fainting"

24 Pulmonary Structure and Function Definitions: Valsalva Maneuver Fig Acute drop in blood pressure Blood pressure overshoot

25 Pulmonary Structure and Function Valsalva Maneuver Fig *Valsalva Maneuver does NOT cause the acute rise in blood pressure with resistance training


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