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Frank M. Andrews, DVM, MS, DACVIM Professor of LA Medicine The University of Tennessee, CVM Diseases of the Stomach.

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Presentation on theme: "Frank M. Andrews, DVM, MS, DACVIM Professor of LA Medicine The University of Tennessee, CVM Diseases of the Stomach."— Presentation transcript:

1 Frank M. Andrews, DVM, MS, DACVIM Professor of LA Medicine The University of Tennessee, CVM Diseases of the Stomach

2 Equine Gastric Ulcer Syndrome Photo courtesy of MJ Murray.

3 Prevalence of Equine Gastric Ulcer Syndrome (EGUS) 60% to 93% in performance horses 25% to 50% in foals Murray et al, Equine Vet J, 1996; Murray, JAVMA, 1989; Murray, AAEP, 1997.

4 EGUS: Public Perceptions Telephone Survey conducted in 2003, of 300 performance horse owners

5 Impact of EGUS on Adult Horses Results in poor body condition Can disrupt training Can impair performance Can cause colic Can have severe complications –duodenal strictures Murray, AAEP, 1997; Murray, Vet Med, 1991.

6 Impact of EGUS on Foals Gastric outflow obstruction Esophagitis Chronic ulceration Perforation (rupture) & peritonitis Photos courtesy of MJ Murray.

7 The Stomach of the Horse Margo plicatus Glandular region (glandular epithelium) Pylorus Esophagus Duodenum Nonglandular region (squamous epithelium)

8 Compartments of the Equine Stomach Squamous (nonglandular) tissue. Less resistant to acid injury. 80% of equine ulcers Glandular & mucus-secreting tissue. More resistant to acid injury. 20% of equine ulcers Pagan, World Equine Vet Rev, 1997.

9 Cause of EGUS: Aggressive Factors Overpowering Defensive Factors Gastric lining damage occurs when: Aggressive (acid, pepsin, bile, organic acids) factors overpower Defenses (bicarbonate, mucus) of gastric mucosa Squamous mucosa lining lacks these defenses Murray, Equine Vet J Suppl, 1992; Sweeney, In Practice, 1992; Pagan, World Equine Vet Rev, 1997; Murray and Schusser, Equine Vet J, SM GM MP

10 Risk Factors for EGUS: Training/Racing Intensive exercise –Reduced blood flow to the stomach lining? –Increased gastric acidity? –Altered eating behavior? March 25 June 3

11 Acids forced into the proximal stomach Increased intra-abdominal presssure during intense exercise causes gastric compression, pushing acid contents into proximal stomach Lorenzo-Figueras and Merritt, AJVR 2002;63: HCl,VFAs Bile acids

12 Risk Factors for EGUS: Feeding Feeding management –Low prevalence of ulcers in horses at pasture Murray et al, Equine Vet J, 1996.

13 Risk Factors for EGUS: Feeding –Decreased acid when roughage available –Increased serum gastrin when fed concentrates (grains & sweet feeds) –Intermittent feed deprivation = gastric ulcers –Stall confinement = gastric ulcers –Feeding alfalfa hay may help!

14 Gastric Acidity Profile: No Feed Murray and Schusser, Equine Vet J, pH 24-Hr Gastric pH: Feed Withheld Time (hours)

15 Gastric Acidity Profile: Grass Hay Murray and Schusser, Equine Vet J, Time (hours) pH 24-Hr Gastric pH: Free Choice Hay

16 Day 0 48 hours 96 hours Hydrochloric Acid-Induced Ulcers Gastric acidity is high in empty stomach Intermittent feed deprivation –Lesions form in squamous mucosa –No lesions form in glandular mucosa –Lesions prevented by ranitidine (Zantac®) Murray and Schusser, Equine Vet J, 1993; Murray and Eichorn, Am J Vet Res, 1996.

17 Risk Factors for EGUS: Stress 1. Physical stress – Illness – Painful musculoskeletal disorder 2. Behavioral stress – Stall confinement – Transport – Unfamiliar environment, social regrouping

18 Risk Factors for EGUS: Non-Steroidal Anti-Inflammatory Drugs Phenylbutazone & Flunixin Meglumine and other NSAIDs Associated with ulcers throughout the intestinal tract (Cecum & Colon) Inhibit prostaglandins, interrupting mucosal blood flow and mucus Local toxicity Murray, Vet Med, 1991.

19 Clinical Signs of EGUS in Adult Horses Poor appetite Poor body condition Attitude changes Decrease in performance Mild to moderate colic Murray, AAEP, 1997.

20 Clinical Signs of EGUS in Foals Poor appetite or intermittent nursing Colic Poor body condition Frequently lies on back Bruxism (grinding of teeth) Excessive salivation (Ptylism) Diarrhea Murray, Vet Med, 1991.

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22 How can you tell that a Horse has EGUS? (Diagnosis) Clinical signs are suggestive of, but not specific for, EGUS Lab: Mild anemia Response to treatment can be useful Gastric endoscopy is only definitive diagnostic tool

23 Endoscopic Evaluation Endoscope quality & dimensions –9 ft long –Small diameter Patient preparation Experience Murray, Vet Med, 1991.

24 Squamous erosions fundus Squamous ulcers lesser curvature Squamous ulcer margo plicatus Endoscopic Evaluation: Adults Murray (personal communication), Photos courtesy of MJ Murray.

25 Glandular ulcer rugal fold Erosion, hyperplasia antrum rugal fold Pyloric ulcer Endoscopic Evaluation: Adults (cont’d) Murray (personal communication), Photos courtesy of MJ Murray.

26 Squamous erosion, desquamation 3 days old Squamous erosions 30 days old Bleeding squamous ulcers 3 months old Endoscopic Evaluation: Foals Murray (personal communication), Photos courtesy of MJ Murray.

27 Glandular corpus ulcers 14 days old2 months old Antrum ulcers 3 months old Pyloric ulcers Endoscopic Evaluation: Foals (cont’d) Murray (personal communication), Photos courtesy of MJ Murray.

28 Treatment of EGUS Eliminate clinical signs Promote healing Prevent complications Prevent recurrences MacAllister, Vet Med,

29 There Are Two Compatible Approaches to Treatment Management modifications Medical therapy-approaches that have been used –Control gastric acid –Mucosal protectants Murray, AAEP, 1997; MacAllister, Vet Med, 1995.

30 Traditional Management Modifications Reduce level of training

31 Diet modifications –Limit periods of fasting –Increase roughage pasture turnout (green grass) free choice hay Alfalfa hay-dietary antacid –Reduce grain/concentrates Seahorn, LSU Equine Vet Res Program Newsletter, 1998; Pagan, World Equine Vet Rev, Traditional Management Modifications

32 Dietary Management Fresh Rice Bran and Rice Bran Oil –Contains surface active phospholipids and cytoprotective factors that maintain health of the stomach lining –Rancidity can be a problem Produces ketoaldehydes which are ulcerogenic –Steam pasteurization can help decrease potential for rancidity –Storage in refrigerator

33 Management Modifications Limit stressful events Long-term stall confinement Trailering Overcrowding

34 Organic Acids (VFAs or SCFAs) High Concentrate Diets Acetic, Butyric, Propionic, and Valeric Acids Byproducts of carbohydrate fermentation in the stomach Synergistic with HCl May lead to non-glandular ulcers Increased VFA’s with increased grain

35 Medical Management of EGUS Neutralizing agents –Antacids Antisecretory agents –Histamine H 2 receptor antagonists –Prostaglandin analog –Acid pump inhibitors Others (antibiotics, neutriceuticals) MacAllister, Vet Med, 1995.

36 **GastroGard , Merial LTD, Atlanta, GA. Only Drug Approved for horses Commonly used Anti-Ulcer Medications, Routes, & Doses Drug Dosage (mg/kg BWT) Dosing interval Route of administration Ranitidine* 6.6Q 6-8 hPO Ranitidine 1.5Q 6 hi.v., i.m. Cimetidine 20-25Q 6-8 hPO Cimetidine 6.6Q 6 hi.v., i.m. Omeprazole **(GastroGard  ) 4Q 24 h PO Omeprazole 0.5Q 24 hi.v. Sucralphate 20-40Q 8 hPO Al/MgOH antacids 0.5 to 1.0 ml/kgQ 4-6 hPO

37 GASTROGARD ® (Omeprazole) New oral-paste formulation of omeprazole developed specifically for horses Well-studied, effective, and safe therapy for EGUS Approved for use in horses, March 1999

38 Ulcer Treatments Act at Different Sites Site of Action H 2 antagonists GASTROGARD™ Sucralfate Antacids H + CI - H 2 (+) ACh (+) Gastrin (+) Prostaglandins (-) H+H+ H+H+ CI - H+H+ STOMACH LUMEN MUCUS/BICARBONATE BARRIER PARIETAL CELL H+H+ H+H+ H+H+ ACID PUMP

39 ImprovedHealed GastroGard ® Allows Healing/Improvement of Ulcers Percent (%) Sham Dosed (n = 25) GASTROGARD (n = 75) 8/25 (32%) 69/75 (92%) 1/25 (4%) 58/75 (77%) Freedom of Information (FOI) Summary for GASTROGARD Oral Paste for Equine Ulcers; Andrews et al, Equine Vet J Suppl, 1999.

40 GastroGard ® Advantages Andrews et al, Comp Cont Educ Pract Bet, Profound gastric acid suppression Prolonged duration of action Once-daily dosing Well studied in horses No reported treatment-related health problems in equine trials Prevents ulcer recurrence Can maintain training program Approved for use in horses (GASTROGARD ® )

41 GastroGard ® : Disadvantages No IV formulation available in US Andrews et al, Comp Cont Educ Pract Bet, 1996.

42 UlcerGard  Prevention of ulcers Non-perscription strength of Gastrogard  Sold through veterinarians

43 Histamine H 2 Receptor Antagonists Zantac® (ranitidine), Tagamet® (cimetidine) Competitive inhibition of the interaction of histamine with parietal cell Dose-dependent inhibition of gastric acid secretion MacAllister, Vet Med, 1995.

44 Histamine H 2 Receptor Antagonists: Advantages & Disadvantages Availability Low cost (generic) Zantac® has been shown to significantly inhibit gastric acid secretion in horses Must be administered 3X daily Murray, AAEP, 1997.

45 Antibiotic Treatment Amoxicillin, metronidazole, clarithromycin, bismuth compounds, etc. Primarily used in humans with Helicobacter pylori H. pylori has been associated with the stomach of horses, but not EGUS Antimicrobials may be used in horses with resistant EGUS

46 Recent Studies on Helicobacter spp. Helicobacter specific DNA isolated from horse stomachs 2 horses with squamous erosions 1 horse with glandular erosions ACVIM Forum-Dallas (May 2002) Scott DR, Marcus EA, Shirazi-Beechey SSP, et al. Evidence of Helicobacter infection in the horse. Proc Am Soc Microbiology 2001.

47 Feed Supplements (Neutriceuticals) NeighLox ® (Kentucky Performance Products) Antacid and Coating Agents: –Aluminum Phosphate, Calcium Carbonate –Dihydroxy-Aluminium Sodium Carbonate Labeled for prevention of heartburn No studies in horses to prove or disprove Probably does not cause any harm

48 Feed Supplements (Neutriceuticals) G.U.T (Uckele Health & Nutrition) Gastric ulcer transnutrient for horses with ulcers Ingredients –Gelatin –Lactobacillus acidophilus, L. lactis Feed 15 grams (1 scoop) twice daily in horses with ulcers No studies proving efficacy

49 Feed Supplements (Neutriceuticals) TractGard (Foxden Equine) Equine GI rehydrator, antacid, digestaid, and electrolyte salt Ingredients (1 to 2 scoops daily) –Calcium carbonate, Sodium sequiscarbonate, KCl, MgSO 4, distiller’s grain, yeast, and linseed meal No studies on efficacy

50 Compounded & Generic Omeprazole: Beware!!

51 Conclusions- General EGUS is a major cause of illness 60-93% of performance horses have EGUS Impacts health, performance, economics Occurs when aggressive factors overpower gastric defenses

52 Conclusions- General Diagnosis requires endoscopy Presumptive diagnosis made based on clinical signs following complete diagnostic evaluation Treatment: management and medical interventions

53 Conclusions- Treatment Zantac®-healing 3X daily treatment Dietary supplements-not tested GastroGard® (omeprazole) –Only FDA approved treatment –Provides potent, long-lasting gastric acid suppression in horses (once daily administration) –92% to 99% improvement in ulcer scores in trials and a wide safety margin UlcerGard  Prevention of Ulcers

54 Duodenal Ulcers/Stricture Part of EGUS (more commonly in foals) Similar pathogenesis Similar clinical signs –Usually associated with bruxism, ptylism, and diarrhea (occurs most often in foals) –Delayed gastric emptying Associated with esophageal ulcers

55 Duodenal Ulcers/Strictures Diagnosis –Clinical signs –Duodenoscopy –Radiology gastric emptying with barium swallows (liquid meal=30 minutes) –Necropsy

56 Duodenal Ulcers/Strictures Treatment –Omeprazole (4 mg/kg, PO, Q24h, 28 days) –Omeprazole (0.5 mg/kg, IV, Q24h) –Ranitidine (6.6 mg/kg, PO, Q8h) Surgery-Gastrojejunostomy (foals only?)

57 Gastric Neoplasia Uncommon in older horses Squamous cell carcinoma, most common –Others: lymphosarcoma, adenosarcoma Arises from squamous mucosa and metastasizes to the abdominal cavity and viscera and/or extends up the esophagus Clinical signs: –Chronic weight loss –Anemia –Naso-gastric reflux –Colic

58 Gastric Neoplasia Diagnosis –Clinical Signs –Endoscopy (definitive) –Abdominal ultrasound –Necropsy Treatment: None Prognosis: Grave

59 Gastric Impaction Infrequent cause of Colic in horses Dry feed material and decreased water intake May occur during winter when dry hay is fed and water intake is lower Diagnosed at surgery in horses with colic Endoscopic examination Treatment with dioctyl sodium succinate (DSS) –5% solution via NG tube in 4 to 6 L fluid Lavage at surgery, resolve in 24 – 48 hours


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