Slide 6 of 27 Alba – GFP bunny Expired in 2002 “Transgenic art” AP Lab #6
Slide 7 of 27 Human Genome Project Completed in 2003 Joint Genome Institute (Walnut Creek, CA) Sequenced entire human genome (DNA) Cost $2.7 billion 2004, Celera (J. Craig Venter) = $300,000,000 (11%) 2010, Illumina (San Diego, CA) = $14,500 (0.0005%) 2013, $1,000 or less
Slide 8 of 27 21 st Century Therapies Gleevec – Chronic Myelogenous Leukemia 1 pill a day Sprycel & Tasigna In 2010, Oncept DNA Vaccine Canine Oral Melanoma Transdermal application June 2010, “siRNA ‘Cure’ for Ebola?” (Geisbert et al.) May 20, 2010, first “synthetic” life form is created
Slide 9 of 27 2013 Biotechnology U. Pitt group produces human heart cells from iPSCs that spontaneously beats on its own Human Liver tissue regrown from iPSCs Surgeons at Duke University implanted a bioengineered blood vessel into patient Netherlands researchers produced lab-grown burger from ONLY cow stem cells.
Slide 10 of 27 Stanford University Newest department: Bioengineering Stanford has a $1,000,000,000 commitment Last department added: 23 years ago Computer Science Silicon Valley MIT Broad Institute of MIT & Harvard (2004) Koch Institute for Integrative Cancer Research (2008)
Slide 12 of 27 The Essence of AP Biology “"if you want easy college Bio credit do dual- enrollment, but if you want to really learn the process and practice of Biology, take AP Bio.” From AP Teacher Community on collegeboard.org
Slide 13 of 27 2013 AP Biology Results Pass Rate = 88% “5”s = 10% Students = 100 There will be zero 1s or 2s this year.
Slide 14 of 27 Why this class is difficult… 1. Honors Biology ≠ AP Biology -- Biology knowledge base may be deficient 2. 42 Chapters (over 1,000 pages) 3. 3 credits vs. 8 credits for college 4. Significant Mathematics focus (Chi-Square Test, etc.) 5. Application & Evaluation Test Questions
Slide 15 of 27 Why this class not difficult… 1. Clear expectations Vocabulary & Objectives 2. Information is readily available 3. Course Materials sourced from 5 Biology textbooks 4. Course materials are easily accessible 5. Few complicated concepts
Slide 16 of 27 What is a College Level Course? Student-Driven Learning “students are expected to work independently outside the class” Role of teacher is to highlight some important points Will NOT cover every concept in class Homework will consist of videos or readings that need to be completed before class
Slide 19 of 27 Class Discussions You WILL be called on to attempt an answer I want to hear what you have to say Please make all questions and comments relevant to the content discussion If your question is off topic, write it down and ask it later
Slide 21 of 27 AP Biology Background Undergrad: Philosophy & Biochemistry Masters: Medical Economics & Epidemiology HHMI (Howard Hughes Medical Institute) Cohort Inaugural Fellow (2008) @ University of Florida AP Summer Institute (2007, 2008, 2009, & 2012) AP Fellows Grant & Stanford University AP Annual Conference (2008, 2012) AP Biology Review at 2012 National Science Bowl Broward County 2013 AP Biology Review Test Item Contributor for 2014 AP Biology Exam
Slide 23 of 27 Summer Project The worksheet is due by 11:59pm on 8/23/13 Email to email@example.com@gmail.com The Online Assessments must be complete by 11:59pm on 8/23/13 In Class Assessment: Biology – Wednesday (8/21/13) Chemistry – Friday (8/23/13)
Slide 24 of 27 BUM Insights Nucleoid / Cell Wall present in bacterial cells? Prokaryotes? Does Golgi Body (Apparatus) contain ribosomes? Need to know the number of chromosomes, chromatids, and chromatin in each stage of mitosis What is the longest phase of the cell cycle?
Slide 25 of 27 BUM In Class Assessment 30 Questions 8 Multiple Correct (Select ALL of the following…) 22 Multiple Choice Spread evenly between 3 topics covered in the BUM About ½ of the questions are application Review the Formative Assessment & Worksheet Think about what would happen if an organelle or molecule were to malfunction. Consider various pathologies of cell organelles, molecular properties of water, and cell cycle
Slide 26 of 27 CUS Insights Polar means it can dissolve in ______ Amino acids can act as BOTH an _____ and a _____ Which functional groups act like acids? Bases? Learn Polar bonds and polar molecule rules Which molecules exhibit Van der Waal forces? Which functional groups have a carbon double bonded to an oxygen?
Slide 27 of 27 CUS In Class Assessment 26 Questions 16 Multiple Choice 10 Multiple Correct Score is out of 25 (one question is effectively Xtra credit) Review the Formative Assessment & Worksheet Functional groups are important
Slide 28 of 27 Upcoming Tests 8/28/13 – First Test TEST Q1-01 (15%) Covers Only Chapters 3-5 Focus is on CH 5 Application & Pathologies 10/14/13 Cumulative Test (20%) Afterschool on Monday 10/14/13 110 students in Auditorium & 60 students in Media Center