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American Heart Association Texas Affiliate Brent Fields Vice President Research Administration & State Health Alliances.

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Presentation on theme: "American Heart Association Texas Affiliate Brent Fields Vice President Research Administration & State Health Alliances."— Presentation transcript:

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2 American Heart Association Texas Affiliate Brent Fields Vice President Research Administration & State Health Alliances

3 Research AHA Top Priority The AHA believes that learning more about the #1 and #3 killers in America is one of the best ways to accomplish our mission: Impact Goal: By 2010, we will reduce coronary heart disease, stroke and risk by 25 percent.

4 The AHA’s commitment to research is reflected in our strategic plan: 1.Increasing the capacity of the research community to generate the highest quality research; 2.Identifying critical research agendas and increasing the understanding of specific cardiovascular issues.

5 Research Expense for Major National Health Agencies: 2004 A American Cancer Society B Alzheimer’s Association C American Diabetes Association D National Multiple Sclerosis Society E March of Dimes F Muscular Dystrophy Association G Juvenile Diabetes Association H American Heart Association

6 AHA’s EXPENDITURES AHA National Budget Expenditures

7 How each dollar is spent Donor Dollar 28.5% 25¢ 75¢ National CenterTexas Affiliate Research Allocation 15¢ 13.5¢

8 Nobel Prize Recipients funded by AHA 1937 – Dr. Albert Szent-Gyorgyi1937 – Dr. Albert Szent-Gyorgyi 1971 – Dr. Earl Sutherland1971 – Dr. Earl Sutherland 1985 – Dr. Joseph Goldstein1985 – Dr. Joseph Goldstein 1985 – Dr. Michael Brown1985 – Dr. Michael Brown 1992 – Dr. Edwin Krebs1992 – Dr. Edwin Krebs 1998 – Dr. Robert Furchgott1998 – Dr. Robert Furchgott 2003 – Dr. Peter Agre2003 – Dr. Peter Agre

9 Milestones Dr. Ancel Keys, supported by funding from the Minnesota Affiliate, first links dietary fat with cholesterol. This discovery spurs the AHA to assume a leading role in urging Americans to cholesterol. This discovery spurs the AHA to assume a leading role in urging Americans to change their eating habits. change their eating habits Dr. Paul Zoll, aided by the Massachusetts Affiliate, publishes the first report of the successful ending of ventricular fibrillation in humans by externally applied countershock. ending of ventricular fibrillation in humans by externally applied countershock Dr. William Wierich, assisted by support from the Minnesota Affiliate and joined by Drs. Vincent Gott and Walter Lillehei, implants the first externally powered pacemaker in a patient Vincent Gott and Walter Lillehei, implants the first externally powered pacemaker in a patient with a surgical heart blockage. with a surgical heart blockage Dr. Albert Starr performs the first long-term successful mitral valve replacement with a caged ball valve, ushering in a new era of valve replacement. He was supported in developing the ball valve, ushering in a new era of valve replacement. He was supported in developing the artificial heart valve by the Oregon Affiliate and assisted by engineer Lowell Edwards. artificial heart valve by the Oregon Affiliate and assisted by engineer Lowell Edwards Dr. Julius Jacobsen, with funding from the Vermont Affiliate, begins performing surgery with the aid of a microscope. Microsurgery ultimately leads to changes in coronary artery surgery, the aid of a microscope. Microsurgery ultimately leads to changes in coronary artery surgery, plastic surgery, neurosurgery, gynecology, limb reimplantation, and orthopedic and tumor plastic surgery, neurosurgery, gynecology, limb reimplantation, and orthopedic and tumor surgery. surgery Drs. Joseph Goldstein and Michael Brown, sponsored by the AHA in 1972, 1973 and 1975, are awarded the Nobel Prize in Physiology or Medicine for their research on the role of low- awarded the Nobel Prize in Physiology or Medicine for their research on the role of low- density lipoprotein receptors in controlling blood cholesterol levels. Their research provides density lipoprotein receptors in controlling blood cholesterol levels. Their research provides new insights into the ways fatty cholesterol enters body cells and why cholesterol levels may new insights into the ways fatty cholesterol enters body cells and why cholesterol levels may become too high. become too high.

10 Texas Research Statistics FY there are currently 154 Texas Researchers funded by the AHAFY there are currently 154 Texas Researchers funded by the AHA (TX Affiliate = 96; National = 58) FY total amount funded =$9,152,708FY total amount funded =$9,152,708 (TX Affiliate = $4,974,265; National = $4,178,443) total funding = $67,993, total funding = $67,993,077 (TX Affiliate = $36,611,162; National $31,381,915) Currently 11 cities and 22 institutions are represented by funded researchers in TexasCurrently 11 cities and 22 institutions are represented by funded researchers in Texas 100+ Texas researchers participated in our TXA Peer Review in100+ Texas researchers participated in our TXA Peer Review in There are currently 15 Research Allocations andThere are currently 15 Research Allocations and Advisory Committee Members (RAAC)

11 Galveston Statistics University of Texas Medical Branch  TXA Applications received/funded for the 2006 cycle = 13/2  TXA Applications received/funded = 100/19  7 Active Researchers = TXA - 6; National – 1  410,500 in Active AHA grants (FY actual spent) (TXA - $345,500; National - $65,000)  $3,728,376 in AHA funding ( allocated) (TXA - $2,355,981; National - $1,372,395) Current Research Allocations & Advisory Committee Members Paul Boor, MD – Professor, Dept. of Pathology

12 Galveston Statistics University of Texas Medical Branch Texas Affiliate – Currently Funded Researchers Kishor Bhakat, PhD Beginning Grant-in-Aid Role of Human AP-endonuclease (APT1/Ref-1) in Regulation of Blood Pressure Perenlei Enkhbaatar, MD, PhD Beginning Grant-in-Aid Role of nitric oxide in pathogenesis of cardiopulmonary derangements in sepsis induced by smoke inhalation and pnemonia Luis Ruess, MD Grant-in-Aid Architecture of the Pore of Connexin43 Channels and Hemichannels Bruns Watts lll, PhD Beginning Grant in Aid Regulation of Renal Transport by Neurotropins Michael Kinsky, PhD Beginning Grant in Aid Pharmacologic Modulation of Fluid Therapy Sutapa Ray, PhD Beginning Grant in Aid STAT3 Signaling in Acute Phase Response

13 Galveston Statistics University of Texas Medical Branch National Center – Currently Funded Researchers Sanjeev Choudhary, PhD Scientist Development Grant Novel Role of the NF-kB inducing kinase in Respiratory Syncytial Virus infection

14 Research Focus Training and career development of beginning scientistsTraining and career development of beginning scientists Support of cutting edge basic and clinical scienceSupport of cutting edge basic and clinical science

15 What Kinds of Research Do We Support? The AHA supports research that is broadly related to the cardiovascular area and stroke.

16 SCIENCE AREAS Basic Cell and Molecular BiologyBasic Cell and Molecular Biology Behavior Science, Epidemiology & PreventionBehavior Science, Epidemiology & Prevention Bioengineering & BiotechnologyBioengineering & Biotechnology BrainBrain Cardiac Biology/RegulationCardiac Biology/Regulation Cardiac Electrophysiology & Arrhythmias/RegulationCardiac Electrophysiology & Arrhythmias/Regulation CardiorenalCardiorenal Cardiovascular DevelopmentCardiovascular Development Cell Transort, Physiology & MetabolismCell Transort, Physiology & Metabolism Immunology and MicrobiologyImmunology and Microbiology Liporproteins, Lipid Metabolism & NutritionLiporproteins, Lipid Metabolism & Nutrition Lung, Respiration & ResuscitationLung, Respiration & Resuscitation

17 SCIENCE AREAS Molecular SignalingMolecular Signaling Radiology & ImagingRadiology & Imaging SurgerySurgery ThrombosisThrombosis Vascular Biology & Blood Pressure/RegulationVascular Biology & Blood Pressure/Regulation Vascular Wall BiologyVascular Wall Biology

18 Programs Offered by AHA National Center Scientist Development GrantScientist Development Grant January and July Application Deadline for January and July activation Fellow to Faculty GrantFellow to Faculty Grant January and July Application Deadline for January and July activation January and July Application Deadline for January and July activation Established Investigator AwardEstablished Investigator Award July Application Deadline for January activation July Application Deadline for January activation

19 Programs Offered by the Texas Affiliate Postdoctoral FellowshipPostdoctoral Fellowship January application deadline for July activation Beginning Grant-in-AidBeginning Grant-in-Aid January application deadline for July activation January application deadline for July activation Grant-in-AidGrant-in-Aid January application deadline for July activation January application deadline for July activation

20 Postdoctoral Fellowship To provide stipend support to help trainees initiate careers in cardiovascular and stroke research, and further research training while obtaining significant research results. (2006 Success Rate for this Program: 51 Applications, 8 funded, 16% funded) Deadline:January 4, 2007 Award: $30,000 - $46,000 stipend, depending on years of training or experience, plus annual $3,000 departmental allowance. plus annual $3,000 departmental allowance. Term:1 or 2 years. May apply for competitive one-year award. Term:1 or 2 years. May apply for competitive one-year award. Full-time research effort and sincere interest in pursuing a career inFull-time research effort and sincere interest in pursuing a career in cardiovascular related research expected. Applicant must hold a doctoral degree and have less than 6 years of post doctoralApplicant must hold a doctoral degree and have less than 6 years of post doctoral research training and experience at award activation (July 1, 2007). Support is limited to work within non-profit institutions in Texas.Support is limited to work within non-profit institutions in Texas. Institutional supplementation permissible under certain conditions.Institutional supplementation permissible under certain conditions. An investigator may sponsor no more than two Affiliate Post Doctoral Fellows at anyAn investigator may sponsor no more than two Affiliate Post Doctoral Fellows at any one time. Any application for a new award that would exceed this limit will not be reviewed. Each of the following criteria will be considered:Each of the following criteria will be considered: –The applicant –The sponsor’s qualifications –The environment and training program resources –The specific research project

21 Beginning Grant-in-aid To Promote the Independent Status of Promising Beginning Scientists by Supporting High Quality, Well-defined Research Projects in the Cardiovascular Area, Including Stroke. (2006 Success Rate for this Program: 90 applications, 21 funded, 23% funded) Deadline:January 4, 2007 Award:$65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI salary, including fringe benefits. salary, including fringe benefits. Term:2 years. Competitive renewal is possible for up to four years of support. Applicants must have: an MD, PhD, DO, DVM, or equivalent doctoral degree.an MD, PhD, DO, DVM, or equivalent doctoral degree. A faculty appointment or equivalent academic or research track position, up toA faculty appointment or equivalent academic or research track position, up to and including a rank of assistant professor, by the time of award activation (July 1, 2007).and including a rank of assistant professor, by the time of award activation (July 1, 2007). The applicant must meet institutional requirements for submission of an extramural, peerThe applicant must meet institutional requirements for submission of an extramural, peer reviewed grant proposal.reviewed grant proposal. No more than 7 years of active faculty appointment prior to award activation (July 1, 2007).No more than 7 years of active faculty appointment prior to award activation (July 1, 2007). No more than $100,000 of all extramural grant support per year, excluding principalNo more than $100,000 of all extramural grant support per year, excluding principal investigator and collaborating investigators salaries, fringe, and intramural fundinginvestigator and collaborating investigators salaries, fringe, and intramural funding Each of the following criteria will be considered:Each of the following criteria will be considered: –Evidence the award will promote the independent status of the applicant –Scientific excellence of the proposal –Qualifications of the applicant, including relevant experience, familiarity with published work in the field and productivity field and productivity –Adequacy of the available resources, including research facilities and institutional environment

22 Grant-in-aid To Support the Most Innovative and Meritorious Research Projects From Independent Investigators in the Cardiovascular Area, Including Stroke. (2006 Success Rate for this Program: 78 applications, 16 funded, 21% funded) Deadline:January 4, 2007 Award:$65,000 per year maximum, including 10% overhead. Up to $15,000 annually for PI salary, including fringe benefits. annually for PI salary, including fringe benefits. Term:2 years. (One year requests are exceptional, but allowed) Term:2 years. (One year requests are exceptional, but allowed) Continuous support of any one investigator is limited to 4 years Applicants must have: An MD, PhD, DO, DVM, or equivalent doctoral degreeAn MD, PhD, DO, DVM, or equivalent doctoral degree A faculty appointment or equivalent academic or research track position, up to and including a rank ofA faculty appointment or equivalent academic or research track position, up to and including a rank of assistant professor, by the time of award activation (July 1, 2007). The applicant must meet institutional requirements for submission of an extramural, peer reviewed grant proposal. No more than $200,000 of all extramural grant support per year, excluding principal investigator andNo more than $200,000 of all extramural grant support per year, excluding principal investigator and collaborating investigators salaries, fringe, and intramural funding Grants will not be awarded to supplement or duplicate any work that is being supported by otherGrants will not be awarded to supplement or duplicate any work that is being supported by other funding agencies. The only exceptions are career development awards. The scientific merit – with emphasis on the innovative nature of the proposal – is the most importantThe scientific merit – with emphasis on the innovative nature of the proposal – is the most importantfactor. Other Criteria include: –The presence of new or original ideas –Clear statement of research –Sufficient experimental detail in the research plan –Understanding of the essential methodology –Adequacy of the experimental design

23 2006 Success Rate – Texas Affiliate Awards Funded = 45 ($5,314,314) 11 cities – 18 institutions (New 2006 Awards) (RAAC allocations from May, 2006 Committee Meeting)

24 2006 Success Rate – National Center Awards Funded = 22 ($7,500,000) 7 cities – 7 institutions (National allocations to Texas for January & July 2006)

25 American Heart Association Texas Affiliate Funding Outcomes / Critical Funding Gap 1 Program Number of Applicants Number of Applicants in Fundable range Number of Applicants Funded % Success Number of Worthy, Unfunded Applications Additional Dollars Needed 2 Postdoctoral Fellowship %14$1,048,000 Beginning Grant-in-Aid %21$2,730,000 Grant-in-Aid %20$2,723,996 Total %55$6,501,996 Amount committed to TXA$5,314,314 1 Established at May TX RAAC meeting for new awards activated July 1. 2 Additional dollars required to fund meritorious proposals which could not be funded due to insufficient resources

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28 Peer Review Structure Western Review Consortium Texas Affiliate Research Committee Consortium Steering Committee WSA Research Committee Peer Review Committees (10)

29 Peer Review Study Groups Brain, Cardiorenal, Lung, Respiration, SurgeryBrain, Cardiorenal, Lung, Respiration, Surgery Behavioral Science, Epidemiology & Prevention,Behavioral Science, Epidemiology & Prevention, CV Regulation, Cardiac (Patho) Physiology, Radiology &CV Regulation, Cardiac (Patho) Physiology, Radiology & Imaging Imaging CV Development, Immunology & Microbiology, Basic Cell &CV Development, Immunology & Microbiology, Basic Cell & Molecular Biology Molecular Biology Lipoproteins & Lipid Metabolism, Thrombosis, Vascular WallLipoproteins & Lipid Metabolism, Thrombosis, Vascular Wall Biology Biology Cell Transport and Metabolism,Cell Transport and Metabolism, Cellular CV Physiology & Pharmacology, Molecular SignalingCellular CV Physiology & Pharmacology, Molecular Signaling

30 Life Cycle of a Research Application Hmm … Application submitted An idea begins Peer Review Committee notification Research completed Yea! Reports Published Findings translated Assigned to reviewers Critique developed Rank- ordered list Research Committee $ Funded

31 The Process Texas Affiliate JanuaryFebruaryMarch April May July Application Deadline Applications assigned to Committees Committee Chairs review assignments Committee Chairs finalize assignments Reviewers input preference Paper copies are sent to reviewers Peer Review Committee meets Research Committees meet Award Notification Award activation  September: online applications are available  October: institutional tour to promote program

32 Other AHA Scientific Products  AHA Professional Membership/Scientific Council  Scientific Statements/Guidelines  Scientific Sessions, Conferences and Workshops  AHA Scientific Journals  My.Americanheart.org

33 QUESTIONS? For Assistance Contact: Brent Fields VP, Research Administration – Phone Rhonda Jennings Administrative Assistant, Research Administration – Phone – fax


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