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Toxins Slackers Facts by Mike Ori. Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not.

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Presentation on theme: "Toxins Slackers Facts by Mike Ori. Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not."— Presentation transcript:

1 Toxins Slackers Facts by Mike Ori

2 Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes. The document can mostly be used forward and backward. I tried to mark questionable stuff with (?). If you want it to look pretty, steal some crayons and go to town. Finally… If you’re a gunner, buck up and do your own work.

3 List the staph aureus toxins

4 Alpha toxin Exfolatin Pyrogenic Toxin Superantigens (PTSAgs) Enterotoxin Toxic Shock Syndrome Toxin (TSST)

5 Alpha toxin effects

6 Pore forming exotoxin

7 Exfolatin symptoms

8 Exfoliation at epidermal stratum spinosum and stratum granulosum

9 PTSags action

10 Activates T cells via MHC-II interaction with APC regardless of TCR fit

11 Staph food poisoning toxin

12 Staph Enterotoxins (PTSags)

13 Enterotoxin effect

14 Vomiting by direct action on nerves.

15 TSST effects

16 Superantigen based shock

17 M protein producer

18 Group A strep (pyogenes)

19 M protein effect

20 Surface antigen Fixes serum factor H which inactivates complement

21 Group A Strep (GAS) toxins

22 Streptolysin O Streptococcal Pryogenic Exotoxin (Spe)

23 Streptolysin O function

24 Pore forming exotoxin

25 Streptolysin O serum sign

26 Anti Strep O antibodies (ASO)

27 Toxin similar to Strep Pyrogenic Exotoxin (Spe)

28 PTSAgs

29 Spe effects

30 Systemic effects like fever, rash

31 Strep agalactiae surface antigen

32 Polysaccharide capsule

33 Strep pneumoniae pore forming exotoxin

34 Pneumolysin

35 Pneumolysin function

36 Pore forming exotoxin

37 Pneumolysin target cells

38 Respiratory epithelium

39 Strep pneumoniae antigen

40 Polysaccharide capsule

41 Corynebacterium diphtheriae toxin

42 Diphtheria toxin (DT)

43 DT function

44 A-B toxin that ADP-ribosylates ribosome EF-2 to halt protein synthesis.

45 Internalin producer

46 Listeria

47 Interalin function

48 Facilitates Listeria entry into cell

49 Listerlysin O function

50 Pore forming exotoxin

51 Bacillis anthracis capsule characteristic

52 D-glutamic acid capsule with antiphagocytic properties

53 Anthrax exotoxin description

54 Three component exotoxin composed of lethal factor, protective antigen, and edema factor. Not well described in notes. I think we only need to know it has one.

55 Clostridium perfringens toxin

56 Alpha toxin

57 Alpha toxin function

58 Kills muscle cells. Not well described in notes.

59 Toxin produced by Clostridium difficile

60 Toxin A – enterotoxin Toxin B – cytotoxin

61 Toxin A effects

62 Hemorrhagic necrosis

63 Toxin B effects

64 Disrupts microfilaments and decreases protein synthesis

65 Name the other two Clostridia toxins

66 Tetanospasmin toxin Botulism toxin

67 Tetanospasmin toxin function

68 Inhibits the action of inhibitory neurons in the anterior horn of the spinal cord to produce rigid paralysis

69 Botulism toxin effects

70 Blocks the release of Ach at the neuromuscular junction to produce flaccid paralysis. Removes wrinkles in foreheads.

71 Bacteriodes fragilis capsule characteristics

72 Polysaccharide capsule that confers resistance to phagocytosis

73 Gram negative endemic toxin

74 Lipopolysaccharide (LPS) AKA endotoxin Common to all Gram-negatives

75 Neisseria menigitidis toxin

76 LPS blebs

77 Neisseria gonorrhea toxin

78 LPS

79 Cholera toxin characteristics

80 An A-B toxin that inhibits GTPase activity of Gas to cause overproduction of cAMP thus causing Cl-, K, HCO3, Na to exit the cell drawing water with them resulting in watery diarrhea.

81 Cholera toxin systemic effects

82 None to speak of as cholera are not invasive.

83 Helicobacter pylori toxin

84 Vacuolating cytotoxin

85 Vacuolating cytotoxin function

86 Causes apoptosis that results in large cytoplasmic vaculoles

87 Cag secretor

88 H pylori

89 Cag entry mechanism

90 Direct injection

91 Cag function

92 Alters cellular proteins and has a strong association with virulence

93 Antecedant cause of gastritis and gastric adenocarcinoma

94 Cag+ strains of H pylori

95 Alpha hemolysin secretor

96 E. Coli

97 Alpha hemolysin function

98 Pore forming exotoxin

99 Shiga toxin secretor

100 EHEC Shigella dysenteriae type 1

101 Shiga toxin effects

102 A-B toxin that binds to the 60s ribosome on the 28s subunit to block the tRNA binding site thus disabling protein synthesis.

103 Labile toxin and stabile toxin secretor

104 ETEC EPEC (?) (Others ??)

105 LT function

106 Increase cAMP

107 LT stability

108 Breaks down at low temp

109 Stabile toxin function

110 Increase cGMP

111 ST stability

112 Breaks down at higher temp and thus is more stabile than LT.

113 Salmonella typhi toxin

114 LPS

115 Hib capsule characteristics

116 Ribose, ribitol, and phosphate (polyribitol phosphate) capsule that is associated with virulence

117 Bordetella pertussis toxin characteristics

118 An A-B toxin that ADP-ribosylates a Gai thus leading to prolonged activation of adenylyl cyclase and a concomitant in cAMP. This interferes with immune cell function,

119 Soluble adenylate cyclase producer

120 B pertussis

121 AC characteristics

122 Increases cAMP production when activated by Ca/calmodulin.

123 Tracheal toxin producer

124 B pertussis

125 Tracheal toxin characteristics

126 A cytotoxic compound that is a fragment of the cell wall of B pertussis. It has direct cytotoxic effects on ciliated respiratory epithelium.

127 Name the Psuedomonas aeruginosa toxins

128 Exotoxin A Elastase Exoenzyme S

129 Exotoxin A function

130 Enters cells to interfere with ribosomal EF-2 to shut down protein synthesis. It is analogous to but not homologous to DT.

131 Elastase function

132 Degrades elastase

133 Exoenzyme S function

134 ADP-ribosylates intracellular proteins including cytoskeleton filament vimentin

135 P aeruginosa capsule description

136 A thick alginate that forms a protective biofilm that is particularly troublesome in CF patients.

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