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Nanotechnology Nano size: Generally 1-100 nm The European Science Foundation definition Nanoscale was seen to range from 1 to 1000 nm.

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Presentation on theme: "Nanotechnology Nano size: Generally 1-100 nm The European Science Foundation definition Nanoscale was seen to range from 1 to 1000 nm."— Presentation transcript:

1 Nanotechnology Nano size: Generally nm The European Science Foundation definition Nanoscale was seen to range from 1 to 1000 nm

2 Particle size classification  1 nmChemical drug  5 nmProtein  10 nmDNA  nmBlood vessel pore  50 nmCarbon nanotube  nmLiposome nanoparticle  1000 nm (1 µm)bacteria  10 µmCell  50 µmHuman hair

3 Cell membrane pore A side view of a pore (blue dots) in the water- channel protein AQP1, which pierces the cell membrane. Cell exterior is at top, interior at bottom. The pore is about 2.8 angstroms across at its narrowest.

4 Advantages of nanoparticles Advantage of nanoparticles - To deliver more effectively: Enhance amount permeate at favorable site, sustain release of actives, increase mucoadhesive (liposome, neosome, nanoparticle, microemulsion, nanoemulsion) - To deliver more effectively: Enhance amount permeate at favorable site, sustain release of actives, increase mucoadhesive (liposome, neosome, nanoparticle, microemulsion, nanoemulsion) - Nano-powder (Zno, TiO 2 etc) - Carbon nanotube

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6 Titanium dioxide nano powder

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9 Toxicology of nanoparticles  Size  Surface area  Surface chemistry  Solubility  Shape  Material type 1) biodegradable 2) Non- biodegradable * Depend on phagocytic clearance

10 Exposure routes

11 Phagocytosis Most Dangerous 2 1 3

12 Limited Experimental toxicology of manufactured nanomaterials reported to date  Fullerenes  Carbon nanotube  Metal oxide nanoparticles (ZnO, TiO 2 )

13 Eight allotropes of carbon: a) Diamond, b) Graphite, c) Lonsdaleite, d) C60 (Buckminsterfullerene or buckyball), e) C540, f) C70, g) Amorphous carbon, and h) single-walled carbon nanotube or buckytube.carbon DiamondGraphite LonsdaleiteBuckminsterfullerene buckyballAmorphous carboncarbon nanotubebuckytube

14 Research work in nanoparticles toxicology  Use carbon single wall carbon nanotube (SWCNT) as model SWCT do not induce cell damage but stimulate fibroblast proliferation and collagen synthesis→ Lung Fibrosis Small well disperse SWCNT penetrate lung tissue more efficiently than agglomeration SWCT induce angiogenesis

15 Nanomaterialization of Chitin- chitosan: Approaches and potential applications  Nanomaterials: the materials which exhibit the special properties due to the function in nanometer range

16 Formation of nanomaterials  Molecolar Architecture: Building from molecular components, Chemical modification  Size reduction: Constructing from large entities, Depolymerization

17 Chitosan Nanosphere  Synthesis - Organic base system: mPEG grafted phthaloylchitin - Water base system: Chitosan-mPEG-CA

18 Self assembly property

19 PEG

20 UV-screening Nanocarrier Based on polyvinylalcohol-co- vinylcinnamate  Chemical modification Amphiphilic polymer: self-assembly: PVA combined UV protective substances


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