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Published byIreland Denmon Modified about 1 year ago

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M/EEG forward problem & solutions Brussels 2011 SPM-M/EEG course January 2011 C. Phillips, Cyclotron Research Centre, ULg, Belgium

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Forward Problem Inverse Problem Source localisation in M/EEG

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Head anatomy Solution by Maxwell’s equations Head model : conductivity layout Source model : current dipole Forward problem

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Ohm’s law : Continuity equation : Maxwell’s equations (1873)

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From Maxwell’s equations find: where M are the measurements and f(.) depends on: signal recorded, EEG or MEG head model, i.e. conductivity layout adopted source location source orientation & amplitude Solving the forward problem

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From Maxwell’s equations find: with f(.) as an analytical solution -highly symmetrical geometry, e.g. spheres, concentric spheres, etc. -homogeneous isotropic conductivity a numerical solution -more general (but still limited!) head model Solving the forward problem

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Con’s: Human head is not spherical Conductivity is not homogeneous and isotropic. Analytical solution Example: 3 concentric spheres Pro’s: Simple model Exact mathematical solution Fast calculation

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Overlapping spheres in MEG Better but…

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Usually “Boundary Element Method” (BEM) : Concentric sub-volumes of homogeneous and isotropic conductivity, Estimate values on the interfaces. Numerical solution Pro’s: More exact head shape modelling Con’s: Mathematical approximations of solution numerical errors Slow and intensive calculation

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Features of forward solution Find forward solution (any) : with f(.) linear in non-linear in If source location is fixed, then

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SPM solutions Source space & head model Template Cortical Surface (TCS), in MNI space. Canonical Cortical Surface (CCS) = TCS warped to subject’s anatomy Subject’s Cortical Surface (SCS) = extracted from subject’s own structural image (BrainVisa/FreeSurfer)

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SPM solutions Jérémie Mattout, Richard N. Henson, and Karl J. Friston, 2007, Canonical Source Reconstruction for MEG

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SPM solutions Source space & head model Template Cortical Surface (TCS), in MNI space. Canonical Cortical Surface (CCS) = TCS warped to subject’s anatomy Subject’s Cortical Surface (SCS) = extracted from subject’s own structural image (BrainVisa/FreeSurfer) Forward solutions: Single sphere Overlapping spheres Concentric spheres BEM … (new things get added to SPM & FieldTrip)

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Solving the Forward Problem is not exciting but necessary… Solution depends on data at hand: MEG vs. EEG: single sphere or overlapping spheres vs. 3 concentric spheres or BEM Structural image available? CCS (good enough) or SCS (tedious work) vs. TCS (best proxy) Sensor location/head position available? Conclusions

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Thank you for your attention

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