1. NIDA Director’s Report to the National Advisory Council on Drug Abuse National Advisory Council on Drug Abuse February 14, 2001

2. NIDA Director’s Report to the National Advisory Council on Drug Abuse NIDA Director’s Report to the National Advisory Council on Drug Abuse Budget Update Shaping the Research Agenda Initiative Implementation Closing the “Great Divide” (a.k.a. Bridging the “Disconnect”) Closing the “Great Divide” (a.k.a. Bridging the “Disconnect”)

3. NIDA Director’s Report to the National Advisory Council on Drug Abuse NIDA Director’s Report to the National Advisory Council on Drug Abuse Budget Update

4. NIDA BUDGET (Thousands) NonAIDS AIDS TOTAL Increase Over Prior Year 1999 Actual $428,490 $188,919 $617,409 +14.0% 2000 Actual $468,758 $217,898 $686,656 +12.4% $535,931 $244,902 2001 Approp. $780,833 +13.7%

5. NIDA BUDGET IMPACT Number of Research Project Grants Noncompeting Awards Competing Awards Competing Awards TOTAL RPGs Awards TOTAL RPGs Success Rate Noncompeting Awards Competing Awards Competing Awards TOTAL RPGs Awards TOTAL RPGs Success Rate 1999 Actual 791 338 1129 34% (Excluding SBIR) 2000 Actual 847 355 1249 38% 2001 Approp. 917 372 1337 35%

6. National Institute of Biomedical Imaging and Bioengineering Establishment Act (H.R. 1795) National Institute of Biomedical Imaging and Bioengineering Establishment Act (H.R. 1795)

7. NIDA Director’s Report to the National Advisory Council on Drug Abuse NIDA Director’s Report to the National Advisory Council on Drug Abuse Budget Update Shaping the Research Agenda

8. Society for Neuroscience 2000 Events: NIDA Neuroscience: Current Status And Future Directions NIDA Neuroscience: Current Status And Future Directions Cellular and Molecular Mechanisms Of Synaptic Vesicle Trafficking Cellular and Molecular Mechanisms Of Synaptic Vesicle Trafficking Cross-Sensitization Between Drugs: A Behavioral and Neural Basis for “Gateway”? Cross-Sensitization Between Drugs: A Behavioral and Neural Basis for “Gateway”? Minority Scholars: Research and Funding Opportunities at the National Institute on Drug Abuse Minority Scholars: Research and Funding Opportunities at the National Institute on Drug Abuse

9. Problems of Global Proportions

10. Normal Control Methamphetamine User Pacific Regional Research Conference On Methamphetamine and Other Amphetamine-Type Stimulants Pacific Regional Research Conference On Methamphetamine and Other Amphetamine-Type Stimulants

11. Developing NIDA’s Plan for International Research Developing NIDA’s Plan for International Research

12. Developing NIDA’s Plan for International Research Developing NIDA’s Plan for International Research We Need YOUR Help! Any Volunteers?

13. NIDA Director’s Report to the National Advisory Council on Drug Abuse NIDA Director’s Report to the National Advisory Council on Drug Abuse Budget Update Shaping the Research Agenda Initiative Implementation

14. Neuroscience Risk and Resilience Risk and Resilience Children and Adolescents Children and Adolescents AIDS and Other Medical Consequences AIDS and Other Medical Consequences Behavioral Science Behavioral Science Epidemiology Treatment Prevention Health Disparities Health Disparities Increased Dollars Are Allowing Us To Expand Efforts in Virtually All of Our Priority Areas! Increased Dollars Are Allowing Us To Expand Efforts in Virtually All of Our Priority Areas!

15. New RFAs “The Transition from Drug Use to Addiction: Unearthing the Switch” “The Transition from Drug Use to Addiction: Unearthing the Switch” “The Next Generation of Drug Abuse Prevention Research” “Health and Developmental Consequences of Prenatal Exposure to Methamphetamine” “Health and Developmental Consequences of Prenatal Exposure to Methamphetamine” “Tools for Insertional Mutagenesis in the Mouse” (with numerous other NIH Institutes) “Tools for Insertional Mutagenesis in the Mouse” (with numerous other NIH Institutes) “HIV/AIDS and Drug Use Among Adolescents”

16. New RFAs (con’t) “Research on GHB and Its Precursors” “International Studies on Drug Abuse and HIV/AIDS” “Responding to Club Drugs and Other Emerging and Current Drug Abuse Trends” “Responding to Club Drugs and Other Emerging and Current Drug Abuse Trends” “Therapeutic Community Research” “Services Research on the National Drug Abuse Treatment Clinical Trials Network” “Services Research on the National Drug Abuse Treatment Clinical Trials Network” “Health Disparities: Drug Use and Its Adverse Behavioral, Social, Medical, and Mental Health Consequences” “Health Disparities: Drug Use and Its Adverse Behavioral, Social, Medical, and Mental Health Consequences”

17. What Else Are We Doing?

18. Neuroscience Risk and Resilience Risk and Resilience Children and Adolescents Children and Adolescents AIDS and Other Medical Consequences AIDS and Other Medical Consequences Behavioral Science Behavioral Science Epidemiology Treatment Health Disparities Health Disparities Prevention

19. Currently Being Updated

20. National Prevention Research Conference National Prevention Research Conference August 9-10, 2001

21. Neuroscience Children and Adolescents Children and Adolescents Risk and Resilience Risk and Resilience AIDS and Other Medical Consequences AIDS and Other Medical Consequences Behavioral Science Behavioral Science Epidemiology Treatment Prevention Health Disparities Health Disparities

22. Combined Workgroup Meeting November 30, 2000 Combined Workgroup Meeting November 30, 2000

23. First Steering Committee Meeting January 18-19, 2001 First Steering Committee Meeting January 18-19, 2001 ational ispanic cience etwork rug on buse

24. Risk and Resilience Risk and Resilience Health Disparities Health Disparities Neuroscience Children and Adolescents Children and Adolescents AIDS and Other Medical Consequences AIDS and Other Medical Consequences Behavioral Science Behavioral Science Epidemiology Prevention Risk and Resilience Risk and Resilience Health Disparities Health Disparities National Drug Abuse Treatment Clinical Trials Network Treatment

25. Let’s talk about Treatment: Let’s talk about Treatment:

26. Intake Processing / Assessment Treatment Plan Pharmacotherapy Continuing Care Clinical and Case Management Self-Help / Peer Support Groups Behavioral Therapy and Counseling Substance Use Monitoring Detoxification Components of Comprehensive Drug Abuse Treatment Drug Abuse Treatment Components of Comprehensive Drug Abuse Treatment Drug Abuse Treatment Child Care Services Vocational Services Medical Services Educational Services AIDS / HIV Services Family Services Financial Services Legal Services Mental Health Services Housing / Transportation Services

27. We’re Beginning to Understand the “Black Box” of Drug Addiction Treatment We’re Beginning to Understand the “Black Box” of Drug Addiction Treatment

28. Simpson, 2001 (Addiction) Treatment Process and Outcomes Model EnhancedCounseling BehavioralStrategies Social Skills Training Family & Friends SupportiveNetworksSupportiveNetworks Induction Personal Health Services Social Support Services SufficientRetentionSufficientRetention PosttreatmentPosttreatment DrugUseDrugUseCrimeCrime SocialRelationsSocialRelations EarlyEngagementProgramParticipationProgramParticipation TherapeuticRelationshipTherapeuticRelationshipEarlyRecoveryBehavioralChangeBehavioralChange Psycho-SocialChangePsycho-SocialChange PatientAttributes at Intake PatientAttributes MotivMotiv ProgramCharacteristicsProgramCharacteristicsCounselorAttributes & Skills CounselorAttributes PosttreatmentPosttreatment DrugUseDrugUseCrimeCrime SocialRelationsSocialRelations Detoxification

29. RESEARCH and Blending PRACTICE NIDA Treatment Initiative

31. The CTN Has Nearly Tripled in Size! The CTN Has Nearly Tripled in Size!

32. National Drug Abuse Treatment Clinical Trials Network National Drug Abuse Treatment Clinical Trials Network Pacific Node UCLA Pacific Node UCLA

33. Northwest Node Oregon Health Sciences University Northwest Node Oregon Health Sciences University Pacific Node UCLA Pacific Node UCLA National Drug Abuse Treatment Clinical Trials Network National Drug Abuse Treatment Clinical Trials Network New England Node Yale University New England Node Yale University Mid-Atlantic Node Johns Hopkins University Medical College of VA Mid-Atlantic Node Johns Hopkins University Medical College of VA Florida Node University of Miami Florida Node University of Miami Rocky Mountain Node University of Colorado Health Sciences Center Rocky Mountain Node University of Colorado Health Sciences Center Southeastern Node Medical University of South Carolina Southeastern Node Medical University of South Carolina Ohio Valley Node University of Cincinnati Ohio Valley Node University of Cincinnati Great Lakes Regional Node Wayne State University Great Lakes Regional Node Wayne State University Delaware Valley Node University of PA Delaware Valley Node University of PA NYC East Side Node NY University/NY VA Med Ctr NYC East Side Node NY University/NY VA Med Ctr

34. Pacific Node UCLA Pacific Node UCLA National Drug Abuse Treatment Clinical Trials Network National Drug Abuse Treatment Clinical Trials Network Mid-Atlantic Node Johns Hopkins University Medical College of VA Mid-Atlantic Node Johns Hopkins University Medical College of VA Pacific Northwest Node University of Washington Pacific Northwest Node University of Washington Long Island Regional Node NY State Psych Inst Long Island Regional Node NY State Psych Inst North Carolina Node Duke University North Carolina Node Duke University New England Node Yale University New England Node Yale University Northwest Node Oregon Health Sciences University Northwest Node Oregon Health Sciences University Florida Node University of Miami Florida Node University of Miami Rocky Mountain Node University of Colorado Health Sciences Center Rocky Mountain Node University of Colorado Health Sciences Center Southeastern Node Medical University of South Carolina Southeastern Node Medical University of South Carolina Ohio Valley Node University of Cincinnati Ohio Valley Node University of Cincinnati Great Lakes Regional Node Wayne State University Great Lakes Regional Node Wayne State University Delaware Valley Node University of PA Delaware Valley Node University of PA NYC East Side Node NY University/NY VA Med Ctr NYC East Side Node NY University/NY VA Med Ctr

35. NIDA/Managed Behavioral Healthcare Summit NIDA/Managed Behavioral Healthcare Summit December 1, 2000

36. 0 0 10 20 30 40 50 60 70 80 90 100 Atlanta Birmingham Chicago Cleveland Dallas Denver Detroit Ft. Lauderdale Houston Indianapolis Los Angeles Miami Minneapolis New Orleans New York City Omaha Philadelphia Phoenix Portland St. Louis Salt Lake City San Diego Seattle Washington DC Atlanta Birmingham Chicago Cleveland Dallas Denver Detroit Ft. Lauderdale Houston Indianapolis Los Angeles Miami Minneapolis New Orleans New York City Omaha Philadelphia Phoenix Portland St. Louis Salt Lake City San Diego Seattle Washington DC Percentage of Male Arrestees Testing Positive for Any Drug in 1998 Percentage of Male Arrestees Testing Positive for Any Drug in 1998 Source: 1998 Arrestee Drug Abuse Monitoring Program (ADAM) Drug Use Correlates with Crime

37. We Need to Treat Addicted Offenders or They Will Be Back! We Need to Treat Addicted Offenders or They Will Be Back!

38. The Good News…

39. Approaches to Addressing Drug Abuse and Addiction Approaches to Addressing Drug Abuse and Addiction We Are Moving Toward A Better Blending of We Are Moving Toward A Better Blending of

40. Percentage of Correctional Facilities Providing Substance Abuse Treatment, 1997 Percentage of Correctional Facilities Providing Substance Abuse Treatment, 1997 Source: SAMHSA, Substance Abuse Treatment in Adult and Juvenile Correctional Facilities: Findings from the Uniform Facility Data Set 1997 Survey of Correctional Facilities, 2000. Source: SAMHSA, Substance Abuse Treatment in Adult and Juvenile Correctional Facilities: Findings from the Uniform Facility Data Set 1997 Survey of Correctional Facilities, 2000. 0 0 10 20 30 40 50 60 70 80 90 100 Total Federal State Jail Juvenile Percent (n=7,539) (n=129) (n=1,183) (n=3,114) (n=3,113) 40% 94% 61% 34% 37%

41. We Don’t Know Much About the Quality of the Programs Being Used… We Don’t Know Much About the Quality of the Programs Being Used… Or the Number of Slots Being Provided Or the Number of Slots Being Provided The Problem is…

42. If Treatment Access and Quality Are Inadequate It Won’t Work! The Problem is…

43. We Need to Make Sure That the Blending of Health and Criminal Justice Approaches Is Not A Failed Experiment! We Need to Make Sure That the Blending of Health and Criminal Justice Approaches Is Not A Failed Experiment!

44. We Need a Council Subcommittee To Define NIDA’s Research Agenda, Rapid Action Mechanisms, and Role We Need a Council Subcommittee To Define NIDA’s Research Agenda, Rapid Action Mechanisms, and Role ….Any Volunteers!

45. NIDA Director’s Report to the National Advisory Council on Drug Abuse NIDA Director’s Report to the National Advisory Council on Drug Abuse Budget Update Shaping the Research Agenda Initiative Implementation Closing the “Great Divide” (a.k.a. Bridging the “Disconnect”) Closing the “Great Divide” (a.k.a. Bridging the “Disconnect”)

46. Reality Perception We Need To Close It! The “Great Divide”

47. “Lets replace ideology with biology” “Lets replace ideology with biology” Abigail Trafford 2001

48. Turning Scientific Breakthroughs Turning Scientific Breakthroughs Into Science in the NEWS Science NEWS

51. April 4, 2001

53. Launch -- April 10, 2001 Prescription Drugs Initiative

54. July 19-20, 2001 MDMA Research Conference

55. www.drugabuse.gov www.drugabuse.gov NIDA NATIONAL INSTITUTE ON DRUG ABUSE NIDA’s Website Has A New Look!