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January 4, 2005 Getting Funded When You Have No Preliminary Data Grants-For-Lunch.

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Presentation on theme: "January 4, 2005 Getting Funded When You Have No Preliminary Data Grants-For-Lunch."— Presentation transcript:

1 January 4, 2005 Getting Funded When You Have No Preliminary Data Grants-For-Lunch

2 Funding Without Data Also known as: Pilot studiesPilot studies Seed moneySeed money Feasibility studiesFeasibility studies Phase I feasibility studiesPhase I feasibility studies Small grantsSmall grants Preliminary studiesPreliminary studies Exploratory/ Developmental GrantsExploratory/ Developmental Grants Sources: NIH R03 NIH R21 GCRC Pilot grants Other pilot projects and seed grants available at UTMB via already funded grants and endowments

3 Common Features of Possible Funding Opportunities (specifics may vary) Little or no preliminary data requiredLittle or no preliminary data required New projects only, no competing continuationsNew projects only, no competing continuations New investigators or investigators exploring a new area are encouragedNew investigators or investigators exploring a new area are encouraged Usually provides a limited amount of money for a limited amount of time (non-renewable)Usually provides a limited amount of money for a limited amount of time (non-renewable) Support may be for early, conceptual stage of development of ideas or for specialized purposesSupport may be for early, conceptual stage of development of ideas or for specialized purposes May involve novel, high-risk or previously unexplored areasMay involve novel, high-risk or previously unexplored areas May pave the way for larger studies or grants or may be intended to further the career of new investigators.May pave the way for larger studies or grants or may be intended to further the career of new investigators.

4 R03 NIH Small Grants Program

5 R03 – Small Grants Getting started / how to beginGetting started / how to begin –http://grants1.nih.gov/grants/funding/r03.htm General Program announcement:General Program announcement: –http://grants.nih.gov/grants/guide/pa-files/PA Not all ICs accept investigator initiated (unsolicited) applicationsNot all ICs accept investigator initiated (unsolicited) applications Check list of ICs before getting startedCheck list of ICs before getting started Applications must include an appropriate Program Announcement number and title on line 2 of the PHS 398 applicationApplications must include an appropriate Program Announcement number and title on line 2 of the PHS 398 application

6 R03 – Small Grants DEFINITIONDEFINITION –Supports small research projects that can be carried out in a short period of time with limited resources. R03 provides support for specialized purposes.

7 R03 – Small Grants SCOPESCOPE –Limited funding for short period of time –Pilot or feasibility studies –Secondary analysis of existing data –Small, self-contained research projects –Development of research methodology –Development of new research technology

8 R03 – Small Grants CHARACTERISTICS (unless specified otherwise in a program announcement or RFA)CHARACTERISTICS (unless specified otherwise in a program announcement or RFA) –Project period up to 2 years –Uses modular budget format –Direct costs up to $50,000 per year –New projects only, no competing continuations –No thesis or dissertation research –Only one revision of previously reviewed R03 –Research Plan may not exceed 10 pages –Competing continuations not accepted

9 R03 – Small Grants CHARACTERISTICS (cont.)CHARACTERISTICS (cont.) –Use PHS 398 forms and instructions –Accepted at standard application deadlines –F & A application – subject to full UTMB rate –Appendix may include only original, glossy photos or color images of gels, micrographs, etc. provided that a photocopy is also included within the page limits of the research plan. No publications or other printed material, with the exception of preprinted questionnaires or surveys, may be included in the appendix.

10 R03 – Small Grants REVIEW CRITERIAREVIEW CRITERIA –Discrete, well defined projects –Realistically completed in two years –Less detail and discussion in research plan than R01 –Less emphasis on methodological details than R01 –Justification for work provided in lit cites, etc. –Prelim data not required, particularly in pilot and feasibility studies –Often designed to support the research of scientists in the early stages of establishing independent research careers.

11 R03 – Small Grants REVIEW CRITERIA (cont.)REVIEW CRITERIA (cont.) –Reviewers will consider the following: Significance – does study address important problem?Significance – does study address important problem? Approach – is project well developed and realistic?Approach – is project well developed and realistic? Innovation – novel concepts used? Existing paradigms or clinical practice challenged?Innovation – novel concepts used? Existing paradigms or clinical practice challenged? Investigator – well trained? Work appropriate to PI experience level?Investigator – well trained? Work appropriate to PI experience level? Environment – does it contribute to probability of success?Environment – does it contribute to probability of success? NOTE: application does not have to be strong in all categories to be judged likely to have major scientific impact

12 R03 – Small Grants REVIEW CRITERIA (cont.)REVIEW CRITERIA (cont.) –Reviewers will consider the following (cont.): Protection of human subjects:Protection of human subjects: –Risk to subjects –Adequacy of protection against risks –Potential benefits of proposed research –Importance of knowledge to be gained –Inclusion of minorities –Inclusion of both sexes / genders –Inclusion of children

13 R03 – Small Grants REVIEW CRITERIA (cont.)REVIEW CRITERIA (cont.) –Reviewers will consider the following (cont.): Care and use of vertebrate animals:Care and use of vertebrate animals: –Proposed use of animals in project (species, strains, ages, sex, and numbers of animals to be used) –Justify use of animals –Information on veterinary care of animals –Procedures to ensure discomfort, distress, pain, etc will be limited to that which is unavoidable –Describe methods of euthanasia to be used, if any

14 R03 – Small Grants NIH ICs that DO accept unsolicited R03sNIH ICs that DO accept unsolicited R03s NEINIANIAAA NIAIDNIBIBNICHD NIDANIDCRNIEHS NIMHNINDSNINR NLM

15 R03 – Small Grants NIH ICs that DO NOT accept unsolicited R03sNIH ICs that DO NOT accept unsolicited R03s FICNCCAMNCI NCMHDNCRRNHGRI NHLBINIAMSNIDCD NIDDKNIGMS

16 R21 NIH Exploratory Developmental Research Grant Award Program

17 R21 – Exploratory Grants Getting started / how to beginGetting started / how to begin –http://grants1.nih.gov/grants/funding/r21.htm General Program Announcement:General Program Announcement: –http://grants.nih.gov/grants/guide/pa-files/PA Not all ICs accept investigator initiated (unsolicited) applicationsNot all ICs accept investigator initiated (unsolicited) applications Check ICs before getting startedCheck ICs before getting started Applications must include an appropriate Program Announcement number and title on line 2 of the PHS 398 applicationApplications must include an appropriate Program Announcement number and title on line 2 of the PHS 398 application

18 R21 – Exploratory Grants DEFINITIONDEFINITION –Intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. Studies may involve considerable risk but may lead to a breakthrough in a particular area. Projects of limited cost or scope that use widely accepted approaches and methods within well established fields are better suited for the R03 small grant mechanism.

19 R21 – Exploratory Grants SCOPESCOPE –Intended for new, exploratory research projects –May involve considerable risk but lead to breakthrough in a particular area –Projects distinct from those supported through R01 mechanism –Projects to increase knowledge in well- established area are not meant for R21 –Projects of limited cost or scope that use widely accepted methods are better suited for R03

20 R21 – Exploratory Grants CHARACTERISTICS (unless specified otherwise in a program announcement or RFA)CHARACTERISTICS (unless specified otherwise in a program announcement or RFA) –Project period up to 2 years –Uses modular budget format –Combined direct costs for 2 years may not exceed $275K, no more than $200K in any one year –New projects only, no competing continuations –Only two revisions of previously reviewed R21 –Research Plan (a – d) may not exceed 15 pages

21 R21 – Exploratory Grants CHARACTERISTICS (cont.)CHARACTERISTICS (cont.) –Preliminary data not required but may be included if available –Use PHS 398 forms and instructions –F & A application – use full UTMB rate –Use instructions for the appendix detailed in the PHS 398 except that no more than 5 manuscripts, previously accepted for publication, may be included.

22 R21 – Exploratory Grants REVIEW CRITERIAREVIEW CRITERIA –Novel, scientific ideas or new model systems –Extensive background material not required –Reviewers will focus on conceptual framework, level of innovation and potential to significantly advance knowledge and understanding –Less emphasis on methodological details than R01 –Justification for work provided in lit cites, etc. –Preliminary data not required

23 R21 – Exploratory Grants REVIEW CRITERIA (cont.)REVIEW CRITERIA (cont.) –Reviewers will consider the following: Significance – does study address important problem?Significance – does study address important problem? Approach – is project well developed and realistic?Approach – is project well developed and realistic? Innovation – novel concepts used? Existing paradigms or clinical practice challenged?Innovation – novel concepts used? Existing paradigms or clinical practice challenged? Investigator – well trained? Work appropriate to PI experience level?Investigator – well trained? Work appropriate to PI experience level? Environment – does it contribute to probability of success?Environment – does it contribute to probability of success?

24 R21 – Exploratory Grants REVIEW CRITERIA (cont.)REVIEW CRITERIA (cont.) –Reviewers will consider the following (cont.): Protection of human subjects:Protection of human subjects: –Risk to subjects –Adequacy of protection against risks –Potential benefits of proposed research –Importance of knowledge to be gained –Inclusion of minorities –Inclusion of both sexes / genders –Inclusion of children

25 R21 – Exploratory Grants REVIEW CRITERIA (cont.)REVIEW CRITERIA (cont.) –Reviewers will consider the following (cont.): Care and use of vertebrate animals:Care and use of vertebrate animals: –Proposed use of animals in project (species, strains, ages, sex, and numbers of animals to be used) –Justify use of animals –Information on veterinary care of animals –Procedures to ensure discomfort, distress, pain, etc will be limited to that which is unavoidable –Describe methods of euthanasia to be used, if any

26 R21 – Exploratory Grants NIH ICs that DO accept unsolicited R21sNIH ICs that DO accept unsolicited R21s NCCAMNCRRNEI NIANIAAANIAID NIBIBNICHDNIDA NIDCDNIDCRNIEHS NIMHNINDSNLM

27 R21 – Exploratory Grants NIH ICs that DO NOT accept unsolicited R21sNIH ICs that DO NOT accept unsolicited R21s FICNCINCMHD NHGRINHLBINIAMS NIDDKNIGMSNINR

28 Sample funded R21 research proposal Mind-Body Interactions and Health: Exploratory/Developmental Research Program “Psychoneuroimmunology, Stress, and Healthy Aging n Hispanics.” R21 application submitted by Dr. Victor Sierpina FY2004: *Mind-Body Interactions and Health: Exploratory/Developmental Research Program “Psychoneuroimmunology, Stress, and Healthy Aging n Hispanics.” R21 application submitted by Dr. Victor Sierpina FY2004: * *Dr. Victor Sierpina, Department of Family Medicine, has granted permission for potential applicants at UTMB to view this document as an example of a R21 Developmental award application that received funding. This proposal was submitted in response to a solicitation: RFA-OB

29 Comparison of R03/R21 R03R03 –Uses widely accepted approaches and methods –Funding for up to 2 years –Modular budget format –Direct costs up to $50,000/yr –New projects only, no competing continuations –Only one revision –Research Plan may not exceed 10 pages R21 –Exploratory and novel approaches and methods –Funding for up to 2 years –Modular budget format –Combined direct costs for 2 years may not exceed $275K, no more than $200K in any one year –New projects only, no competing continuations –Only two revisions –Research Plan (a – d) may not exceed 15 pages

30 Comparison of R03/R21(cont.) R03R03 –No thesis or dissertation research –Use PHS 398 forms and standard application deadlines –Use full UTMB F&A rate –Appendix may include original, color/glossy images, provided a photocopy is also included within the page limits of the research plan. No publications or other printed material, with the exception of preprinted questionnaires or surveys. R21 –Preliminary data not required –Use PHS 398 forms –Use full UTMB F&A rate –Use PHS398 instructions for Appendix, except no more than 5 manuscripts, previously accepted for publication, may be included.

31 Pilot Funding available on the UTMB campus

32 UTMB Pilot Funding GCRC Clinical Research Feasibility Funds (CReFF) The CReFF Program focuses on support for pilot studies. The purpose is to support promising investigator-initiated human studies on the GCRC that might not otherwise be possible without this support, and to encourage investigators to propose pilot studies to be conducted on the GCRC. Support will be given for a defined GCRC protocol for up to one year. Priority will be given to junior investigators with appropriate mentors who propose pilot observations that are likely to lead to extramural grant support. For more information, contact the General Clinical Research Center at Clinical Research Feasibility Funds (CReFF) The CReFF Program focuses on support for pilot studies. The purpose is to support promising investigator-initiated human studies on the GCRC that might not otherwise be possible without this support, and to encourage investigators to propose pilot studies to be conducted on the GCRC. Support will be given for a defined GCRC protocol for up to one year. Priority will be given to junior investigators with appropriate mentors who propose pilot observations that are likely to lead to extramural grant support. For more information, contact the General Clinical Research Center at

33 UTMB Pilot Funding (cont.) UTMB Center on Aging External Funding for Aging Research and Education/training Programs Emphasis on funding pilot projects: The Sealy Center on Aging has been able to award pilot funding based on funds received from the Sealy endowment, the Claude D. Pepper Older Americans grant (funds 3 to 4 pilots per year), and the Center for Populations Health and Health Disparities grant (funds 4 pilots per year). From the Sealy Center on Aging has awarded funds to support 46 pilot projects. Several pilot projects have produced R01 grants.UTMB Center on Aging External Funding for Aging Research and Education/training Programs Emphasis on funding pilot projects: The Sealy Center on Aging has been able to award pilot funding based on funds received from the Sealy endowment, the Claude D. Pepper Older Americans grant (funds 3 to 4 pilots per year), and the Center for Populations Health and Health Disparities grant (funds 4 pilots per year). From the Sealy Center on Aging has awarded funds to support 46 pilot projects. Several pilot projects have produced R01 grants.

34 UTMB Pilot Funding (cont.) Center for Population Health and Health Disparities (CPHHD) Pilot Research Grants Funding of up to $50,000 per year for up to two years is available to support pilot projects involving health disparities. A priority for this funding is to stimulate laboratory-based and interdisciplinary investigations exploring mechanisms for disparities in health by ethnicity, socioeconomic status, etc. A major component of the UTMB CPHHD is a population based longitudinal study of stress and health in approximately 2,000 Mexican American adults in Galveston County. This program was offered for the first time in the fall of 2003 with funding originating with NIH. The last round was held in October, For further information contact: Kyriakos Markides, or James S.Goodwin, for Population Health and Health Disparities (CPHHD) Pilot Research Grants Funding of up to $50,000 per year for up to two years is available to support pilot projects involving health disparities. A priority for this funding is to stimulate laboratory-based and interdisciplinary investigations exploring mechanisms for disparities in health by ethnicity, socioeconomic status, etc. A major component of the UTMB CPHHD is a population based longitudinal study of stress and health in approximately 2,000 Mexican American adults in Galveston County. This program was offered for the first time in the fall of 2003 with funding originating with NIH. The last round was held in October, For further information contact: Kyriakos Markides, or James S.Goodwin,

35 UTMB Pilot Funding (cont.) Center for Addiction Research: Fostering Advances in Addiction Science Pilot Grant Program Funds research in the mechanisms/processes underlying drug abuse and addiction, including (but not limited to) targeted genomic/proteomic studies to discover molecular mechanisms of addiction, translational research in addiction and systems biology approaches to integrative models of addiction. Up to three pilot grants ($30,000 each) for one year, with possibility for two years. Faculty at the Assistant Professor level and above are eligible to apply. The program is designed to promote interdisciplinary research collaborations among UTMB faculty that will ultimately result in external funding. The last due date was November 29, For further information: Theresa Tarrant, for Addiction Research: Fostering Advances in Addiction Science Pilot Grant Program Funds research in the mechanisms/processes underlying drug abuse and addiction, including (but not limited to) targeted genomic/proteomic studies to discover molecular mechanisms of addiction, translational research in addiction and systems biology approaches to integrative models of addiction. Up to three pilot grants ($30,000 each) for one year, with possibility for two years. Faculty at the Assistant Professor level and above are eligible to apply. The program is designed to promote interdisciplinary research collaborations among UTMB faculty that will ultimately result in external funding. The last due date was November 29, For further information: Theresa Tarrant,

36 UTMB Pilot Funding (cont.) CIRWH Seed Grant Program The Center for Interdisciplinary Research on Women’s Health seed grants are intended to support promising basic, clinical, or translational research relevant to the general area of women’s health and likely to lead to significant external grant funding. The next round of these competitive grants of $12,500 will be announced in the spring. The grants will be open to UTMB faculty at the assistant professor level and above who are conducting research in women's health. The center also encourages applications from more senior UTMB investigators gathering pilot data for new multidisciplinary projects in women's health. The last round was held in September, For further information contact: Joanna Bremer, Seed Grant Program The Center for Interdisciplinary Research on Women’s Health seed grants are intended to support promising basic, clinical, or translational research relevant to the general area of women’s health and likely to lead to significant external grant funding. The next round of these competitive grants of $12,500 will be announced in the spring. The grants will be open to UTMB faculty at the assistant professor level and above who are conducting research in women's health. The center also encourages applications from more senior UTMB investigators gathering pilot data for new multidisciplinary projects in women's health. The last round was held in September, For further information contact: Joanna Bremer,

37 UTMB Pilot Funding (cont.) NIEHS Center in Environmental Toxicology at UTMB Pilot Projects Limited funds are available to support Pilot Project studies in the Environmental Health Sciences. Research proposals should have a strong emphasis on the Center’s interests in the environmentally- related problems of oxidative stress and signaling, DNA repair and mutagenesis, biotransformation, asthma pathogenesis, and environmentally based community outreach and education programs. Special priority will be placed on applications which emphasize collaborative efforts. It is anticipated that four pilot projects will be funded for up to $17,500 for one year. The next deadline is February 15, Contact: RayKay Santa, or Jonathan B. Ward, Center in Environmental Toxicology at UTMB Pilot Projects Limited funds are available to support Pilot Project studies in the Environmental Health Sciences. Research proposals should have a strong emphasis on the Center’s interests in the environmentally- related problems of oxidative stress and signaling, DNA repair and mutagenesis, biotransformation, asthma pathogenesis, and environmentally based community outreach and education programs. Special priority will be placed on applications which emphasize collaborative efforts. It is anticipated that four pilot projects will be funded for up to $17,500 for one year. The next deadline is February 15, Contact: RayKay Santa, or Jonathan B. Ward,

38 UTMB Mind-Body Research Scholars Program Provides seed grants to help foster interdisciplinary mind-body research through mentoring, training in research tools, techniques and writing skills. Seed grants in the amount of $ for the period of 1 year. Approximately 4-6 researchers will be awarded annually. UTMB tenure and non-tenure track faculty at the assistant professor level or above are eligible to apply. Preference will be given to junior faculty and investigators entering mind- body research as a new field. Applications are also encouraged from UTMB investigators gathering pilot data for new multidisciplinary projects in the area of stress and coping behaviors addressing the needs of Hispanic patients and the elderly. The deadline for the first round (FY2005) is in February 14. Contact: Pam Bass or Dr. Victor Sierpina, Mind-Body Research Scholars Program Provides seed grants to help foster interdisciplinary mind-body research through mentoring, training in research tools, techniques and writing skills. Seed grants in the amount of $ for the period of 1 year. Approximately 4-6 researchers will be awarded annually. UTMB tenure and non-tenure track faculty at the assistant professor level or above are eligible to apply. Preference will be given to junior faculty and investigators entering mind- body research as a new field. Applications are also encouraged from UTMB investigators gathering pilot data for new multidisciplinary projects in the area of stress and coping behaviors addressing the needs of Hispanic patients and the elderly. The deadline for the first round (FY2005) is in February 14. Contact: Pam Bass or Dr. Victor Sierpina, UTMB Pilot Funding (cont.)

39 John Sealy Memorial Endowment Fund for Biomedical Research: Research Development Grants The purpose of the Research Development Grant program is to stimulate the development of new research initiatives through the support of pilot projects that have a very high probability of attracting new biomedical research grants to UTMB. Investigators at the rank of Assistant Professor or above are eligible to apply. Grants may be awarded for up to $35,000 per year for up to two years. Applications accepted: January, April and September. The next deadline (for 2005 only) is February 1, Contact: Helen Cook, Sealy Memorial Endowment Fund for Biomedical Research: Research Development Grants The purpose of the Research Development Grant program is to stimulate the development of new research initiatives through the support of pilot projects that have a very high probability of attracting new biomedical research grants to UTMB. Investigators at the rank of Assistant Professor or above are eligible to apply. Grants may be awarded for up to $35,000 per year for up to two years. Applications accepted: January, April and September. The next deadline (for 2005 only) is February 1, Contact: Helen Cook,

40 Resources for identifying funding when you have no preliminary data Research Services Website: Services Website: UTMB Yellow Sheet Yellow Sheet SPIN funding database and SMARTS GENIUS funding alerts funding database and SMARTS GENIUS funding alerts NIH Guide Guide NIH Website for new investigators: Website for new investigators: Contact: Linda Crumpler, Reference Librarian Research Services Funding Library Rebecca Sealy East Room 4.400D Route 0156 Phone:


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