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Education/Project Module Blood Flow Lessons on concepts of the human circulatory system Regulation of blood flow hemostasis and thrombosis Effect of pressure.

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Presentation on theme: "Education/Project Module Blood Flow Lessons on concepts of the human circulatory system Regulation of blood flow hemostasis and thrombosis Effect of pressure."— Presentation transcript:

1 Education/Project Module Blood Flow Lessons on concepts of the human circulatory system Regulation of blood flow hemostasis and thrombosis Effect of pressure and velocity on blood flow Christine Karklins

2 Education Module - Requisite background Human circulatory system knowledge Blood and its components Blood coagulation basics Viscosity and its effect on flow rate Pressure and flow/relationships

3 Educational Module Examples Human blood & components Coagulation Blood & related anomalies

4 Educational Module Materials syringe Tubing and connectors Graduated cylinders - measure solutions Food coloring - instead of buffer solution Y connectors - branches in “vessels” Corn starch

5 Components:syringe, tubing Input: Fluid (Water+food color) Output: Measure outlet flow rate Compute: Velocity (vary diameter) Analysis: Relationship (flow,velocity, diameter) STEP 1: circulation model Project Module – 5 step experiment Observe and listen to students as they work individually and in groups.

6 Branching With Clot

7 STEP 2: EFFECT OF BLOOD VISCOSITY Use Model described in Step 1 Measure the effects of viscosity on blood flow Add corn starch to thicken the “blood” for viscousness Calculate the flow rate as function of relative viscosity Theoretically calculate the flow rate of patients with anomalies in blood cell counts and corroborate with this model.

8 STEP 3: BRANCHING model Components: syringe, tubing, connectors Input: Fluid (Water+food color) Output: Measure outlet flow rate Compute: Velocity (vary diameter) Analysis: Effect of distributed blood flow (flow rate, velocity)

9 STEP 4: DEEP VEIN THROMBOSIS (DVT) model Components: syringe, tubing, cotton balls Input: Fluid (Water+food color) Assembly: Cotton of different thickness/density plugged into tubing Output: Measure outlet flow rate) Analysis: Effect of ‘clot’ on flow rate Improvements: Model ‘clot’ dissolution, movement

10 Objectives: familiarity with prosthetic materials stents, vascular grafts (tube like) Components: vascular grafts, stents, pump Focus in research is on the development of anti- thombotic materials Model stent, grafts for presentation. STEP 5: Synthetic biomaterials & Thrombosis StentHeart Valve Catheter

11 Assessment Activity Post-test: Assesses the students’ knowledge of the circulatory system Assess the students understanding of blood and its components Experiment/Lab Report: Assesses the students’ knowledge of the engineering principles that govern the circulatory system. Assess the ability of the student to grasp the concepts of experimental in vitro experiments

12 Extention Activity Students may choose one of the following projects as a culminating activity: Research on circulatory system, blood and coagulation. Presentation: Create a Poster Board or Pamphlet to educate their school/community about the human circulatory system in the context of…hemostasis, thrombus, the heart and heart disease. Research important people, events, inventions, and advancements in bioengineering. Investigate and report on current and future technologies used to treat vascular disease.

13 Ethics Case study…present students with a scenario in which a scientist does not include data that is inconsistent with his conclusion. Have class discussion on ethical considerations of omitting data. Maintenance of graft-5yr life span for material Code of ethics online Discussion: What data should be kept? What data should be thrown out? Why? Discuss design criteria for ideal vascular graft, limitations and successes of current grafts. Justice issues.

14 Analyze the pure and applied research nature of science Evaluate public perceptions of value of scientific research Assess short- and long-term risks/benefits of specific pure research which directly led, or may lead, to direct applications.


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