Presentation is loading. Please wait.

Presentation is loading. Please wait.

John H. Alexander, MD Director, Heart Center SBR Co-Director, DCRI CV Research American Heart Association Update “Highlights of the AHA” “Duke at the AHA”

Similar presentations


Presentation on theme: "John H. Alexander, MD Director, Heart Center SBR Co-Director, DCRI CV Research American Heart Association Update “Highlights of the AHA” “Duke at the AHA”"— Presentation transcript:

1 John H. Alexander, MD Director, Heart Center SBR Co-Director, DCRI CV Research American Heart Association Update “Highlights of the AHA” “Duke at the AHA” Cardiology Grand Rounds November 23, 2010

2 All Rights Reserved, Duke Medicine 2008 John Alexander: Disclosures (2010) Research Support: Bristol Myers Squibb, CSL Behring, Medtronic Japan, Merck, NIH, Pfizer, Regado Biosciences Consulting: Astra Zeneca, Boeringer Ingelheim, Bristol Myers Squibb, CSL Behring, Medsphere, Novartis, Ortho-McNeil- Jannsen, Otsuka Pharmaceuticals, Regado Biosciences Disclosures available: https://dcri.org/about-us/conflict-of-interest

3 All Rights Reserved, Duke Medicine 2008 Agenda Hot Science Duke at the AHA Modern Communication “The grand rounds tomorrow is intended to generate discussion on how to incorporate the late-breaking science into our clinical practice. So please join us and prepare to discuss.” (Tracy Wang, MD - 11/22/10)

4 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHISIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ● 

5 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHASIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ●  “It is Rocket Science!”

6 RivaroxabanWarfarin Primary Endpoint: Stroke or non-CNS Systemic Embolism INR target ( inclusive) 20 mg daily 15 mg for Cr Cl ml/min Atrial Fibrillation Randomize Double Blind / Double Dummy (n ~ 14,000) Monthly Monitoring Adherence to standard of care guidelines Study Design * Enrollment of patients without prior Stroke, TIA or systemic embolism and only 2 factors capped at 10% Risk Factors CHF Hypertension Age  75 Diabetes OR Stroke, TIA or Systemic embolus At least 2 or 3 required*

7 Primary Efficacy Outcome Stroke and non-CNS Embolism Event Rates are per 100 patient-years Based on Protocol Compliant on Treatment Population No. at risk: Rivaroxaban Warfarin Warfarin HR (95% CI): 0.79 (0.66, 0.96) P-value Non-Inferiority: <0.001 Days from Randomization Cumulative event rate (%) Rivaroxaban Warfarin Event Rate

8 RivaroxabanWarfarin Event Rate HR (95% CI) P-value On Treatment N= 14, (0.65,0.95) ITT N= 14, (0.74,1.03) Rivaroxaban better Warfarin better Primary Efficacy Outcome Stroke and non-CNS Embolism Event Rates are per 100 patient-years Based on Safety on Treatment or Intention-to-Treat thru Site Notification populations

9 RivaroxabanWarfarin Event Rate HR (95% CI)P-value Vascular Death, Stroke, Embolism (0.84, 1.05)0.265 Stroke Type Hemorrhagic Ischemic Unknown Type (0.38, 0.89) 0.99 (0.82, (0.55, 2.01) Non-CNS Embolism (0.42, Myocardial Infarction (0.72, 1.16)0.464 All Cause Mortality Vascular Non-vascular Unknown Cause (0.82, 1.03) 0.94 (0.81, 1.08) 0.94 (0.75, 1.18) 0.80 (0.57, 1.12) Key Secondary Efficacy Outcomes Event Rates are per 100 patient-years Based on Intention-to-Treat Population

10 RivaroxabanWarfarin Event Rate or N (Rate) HR (95% CI) P- value Major >2 g/dL Hgb drop Transfusion (> 2 units) Critical organ bleeding Bleeding causing death (0.90, 1.20) 1.22 (1.03, 1.44) 1.25 (1.01, 1.55) 0.69 (0.53, 0.91) 0.50 (0.31, 0.79) Intracranial Hemorrhage55 (0.49)84 (0.74)0.67 (0.47, 0.94)0.019 Intraparenchymal37 (0.33)56 (0.49)0.67 (0.44, 1.02)0.060 Intraventricular2 (0.02)4 (0.04) Subdural14 (0.13)27 (0.27)0.53 (0.28, 1.00)0.051 Subarachnoid4 (0.04)1 (0.01) Event Rates are per 100 patient-years Based on Safety on Treatment Population Primary Safety Outcomes

11 Conclusions  Efficacy : Rivaroxaban was non-inferior to warfarin for prevention of stroke and non-CNS embolism. Rivaroxaban was superior to warfarin while patients were taking study drug. By intention-to-treat, rivaroxaban was non-inferior to warfarin but did not achieve superiority.  Safety : Similar rates of bleeding and adverse events. Less ICH and fatal bleeding with rivaroxaban.  Conclusion : Rivaroxaban is a proven alternative to warfarin for moderate or high risk patients with AF.

12 Stroke or Systemic Embolism Dabigatran 110 vs. Warfarin Dabigatran 150 vs. Warfarin Non-inferiority p-value <0.001 Superiority p-value 0.34 <0.001 Margin = 1.46 HR (95% CI)

13 All Intracranial Bleeding Years Cumulative Hazard Rates Dabigatran110 Dabigatran150 Warfarin # at RiskYear D110 D150 W

14 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHASIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ● 

15 EMPHASIS-HF: Major results EMPHASIS-HF OutcomeEplerenone (%)Placebo (%)Adjusted hazard ratio (95% CI) p Cardiovascular death/heart-failure hospitalization (0.54–0.74)<0.001 Cardiovascular death (0.61–0.94)0.01 Heart-failure hospitalization (0.47–0.70)<0.001 Hospitalization for hyperkalemia (0.25–5.31)0.85 NYHA Class II HF (N=2737) LV EF < 30% Eplerenone 25-50mg QD vs. Placebo

16 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHASIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ●  “a small phase II trial in the eyes of someone in the ACS world”

17 Background  Acute heart failure is a major health problem responsible for several million hospitalizations worldwide each year.  Standard therapy has not changed since 1970s and includes diuretics and variable use of vasodilators or inotropes.  In 2001, nesiritide was approved by the FDA to reduce PCWP and improve dyspnea, based on efficacy at 3 hrs.  However, in 2005 two meta-analyses raised concerns regarding the risks of mortality and renal injury.  Subsequently, an independent panel* was convened by Scios Inc and recommended that a clinical trial be conducted to definitively answer the question of nesiritide’s safety and efficacy.

18 To assess whether nesiritide vs placebo, in addition to standard care provides: Reduction in rate of HF rehospitalization or all-cause mortality through Day 30 Significant improvement in self-assessed dyspnea at 6 or 24 hrs using 7-point Likert scale Co-Primary objectives % Subjects Markedly Better Minimally Worse Moderately Better Moderately Worse Minimally Better Markedly Worse No Change

19  Double – blind placebo controlled  IV bolus (loading dose) of 2 µg/kg nesiritide or placebo Investigator’s discretion for bolus Followed by continuous IV infusion of nesiritide 0.01 µg/kg/min or placebo for up to 7 days  Usual care per investigators including diuretics and/or other therapies as needed  Duration of treatment per investigator based on clinical improvement Study design and drug procedures Nesiritide Placebo 24–168 hrs Rx Acute HF < 24 hrs from IV RX Co-primary endpoint: Dyspnea relief at 6 and 24 hrs Co-primary endpoint: 30-day death or HF rehosp All-cause mortality at 180 days

20 Co-Primary outcome: 30-day all-cause mortality or HF rehospitalization Hazard Ratio 0.93 (95% CI: 0.8,1.08) Placebo Nesiritide HF Rehospitalization30-day Death/HF Rehospitalization 30-day Death Risk Diff (95 % CI) -0.7 (-2.1; 0.7) -0.4 (-1.3; 0.5) -0.1 (-1.2; 1.0) % P=0.31

21 % Subjects 24 Hours Markedly Better Minimally Worse Moderately Better Moderately Worse Minimally Better Markedly Worse No Change Co-Primary Endpoint: 6 and 24 hour dyspnea % Subjects Hours 3444 Placebo P= Nesiritide Placebo Nesiritide P= %44.5% 66.1% 68.2%

22 Renal Safety Anytime Through Day 30 Placebo (n=3509) Nesiritide (n=3498) P-value >25% decrease eGFR29.5%31.4%0.11 End of Treatment Creatinine Creatinine (mg/dL) Cum Dist Discharge or 10 day Creatinine Creatinine (mg/dL) Cum Dist Nesiritide Placebo

23 (n=3509) Nesiritide (n=3498) Risk Difference (95% CI) P- value Any hypotension (Through Day 10/discharge) 15.3% (538) 26.6% (930) 11.3 (9.4 to 13.1) <.001 Asymptomatic Hypotension 12.4% (436) 21.4% (748) 9.0 (7.2 to 10.7) <.001 Symptomatic Hypotension 4.0% (141) 7.1% (250) 3.1 (2.1 to 4.2) <.001 Hypotension

24  Nesiritide did not reduce the rate of recurrent heart failure hospitalization or death at 30 days.  Nesiritide reduced dyspnea to a modest degree, consistent with previous findings but did not meet pre- specified protocol criteria for statistical significance at 6 and 24 hours.  Nesiritide did not affect 30-day all cause mortality nor did it worsen renal function as had been suggested by prior meta-analyses of smaller studies. Conclusions

25 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHISIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ● 

26 Standard-Dose Clopidogrel † clopidogrel 75-mg daily X 6 months High-Dose Clopidogrel † clopidogrel 600-mg, then clopidogrel 150-mg daily X 6 months Elective or Urgent PCI with DES* VerifyNow P2Y12 Test hours post-PCI PRU ≥ 230 R R GRAVITAS Study Design † placebo - controlled Primary Efficacy Endpoint: CV Death, Non-Fatal MI, Stent Thrombosis at 6 mo Key Safety Endpoint: GUSTO Moderate or Severe Bleeding at 6 mo Pharmacodynamics: Repeat VerifyNow P2Y12 at 1 and 6 months All patients received aspirin (81-162mg daily) *Peri-PCI clopidogrel per protocol-mandated criteria to ensure steady-state at hrs

27 5429 patients screened with VerifyNow P2Y hours post-PCI 2214 (41%) with high residual platelet reactivity (PRU ≥ 230) 3215 (59%) without high residual platelet reactivity (PRU < 230) Clopidogrel High Dose N=1109 Clopidogrel Standard Dose N=1105 GRAVITAS Patient Flow

28 Pharmacodynamics: Effect of SD vs HD Clopidogrel PRU value Post-PCI High-Dose 30 d 6 moPost-PCI30 d 6 mo Standard-Dose N=1013N=940N=1105 N=1012N=944N=1109 P = 0.98 P < ITT population Persistently high 30 days: 62% vs 40%, p<0.001

29 Primary Endpoint: CV Death, MI, Stent Thrombosis Observed event rates are listed; P value by log rank test.

30 Bleeding Events: Safety Population P by log rank test; observed event rates listed. HD, high-dose; SD, standard dose Severe or life-threatening: Fatal bleeding, intracranial hemorrhage, or bleeding that causes hemodynamic compromise requiring blood or fluid replacement, inotropic support, or surgical intervention Moderate: Bleeding that leads to transfusion but does not meet criteria for severe bleeding

31 GRAVITAS: Summary Compared with standard-dose therapy, high-dose clopidogrel achieved a modest pharmacodynamic effect in patients with high residual reactivity. In patients with high residual reactivity measured after PCI, 6-months of high-dose clopidogrel did not reduce the rate of cardiovascular death, non- fatal MI, or stent thrombosis and did not increase GUSTO severe or moderate bleeding.

32 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHASIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ● 

33 Reperfusion of Acute Myocardial Infarction in Carolina Emergency Departments – Emergency Response (RACE-ER) Project on behalf of RACE Coordinators, Nurses, Physicians, Paramedics, and Administrators

34 Regional approach to overcoming systematic barriers 1) Increase reperfusion rate 2) Increase speed of reperfusion RACE Pilot RACE 65 hospitals RACE - ER 119 hospitals Objectives

35 Primary PCI (21) Transfer for Primary PCI (52) Lytics (31) Mixed (15) (primary PCI if transport readily available RACE Hospitals by PCI and Reperfusion Designation

36 Reperfusion Strategy Overall population, Eligible Patients P = for PCI group trend

37 Use of Pre-hospital 12-lead ECG (Direct presenters via EMS to PCI Centers)

38 Transfer Patients: Time to lytic or to device by designation strategy

39 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHASIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ● 

40 A Randomized, Double-blind, Placebo-controlled Trial of Intravenous Erythropoietin in Patients with ST-Segment Elevation Myocardial Infarction – Primary Results of the REVEAL Trial

41 STEMI n=110 Primary or rescue PCI TIMI 0-1 flow in IRA Primary or rescue PCI TIMI 0-1 flow in IRA Successful PCI IV EPO Matching saline placebo placebo Infarct size in IRA territory 2-6 days by cMRI - Randomize - Study drug within 4 hrs

42 Results: Primary endpoint Mean (SE) infarct size at 2-6 days after study drug admin EPO vs. placebo 15.8% vs. 15.0%, P=NS P-value adjusted for age, infarct location, enrollment phase EPOPlacebo Infarct Size (%LV)

43 Conclusions n These data, coupled with the lack of efficacy seen in other STEMI trials involving EPO (REVIVAL-3 1, HEBE III 2 ), do not support the hypothesis that EPO favorably impacts outcome after reperfusion for STEMI n Whether earlier administration or alternate dosing provides a cardioprotective effect of EPO in humans remains to be determined 1 Ott I, et. al. Circ:CV Intv Voors AA, et. al. EHJ 2010

44 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHASIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ● 

45 Background: CETP inhibition HDL LDL / VLDL Liver Bile CE LDL-R FC FC LCAT CETP CE SR-B1 X inhibition Cholesteryl ester transfer protein (CETP) is a plasma protein that catalyzes the transfer of CE from HDL to apoB-containing lipoproteins (VLDL and LDL-C) in exchange for Trig. Free Cholesterol (FC) in Extrahepatic tissues

46 Anacetrapib l Orally active, potent, selective CETP inhibitor l Robust lipid efficacy in Phase I-II studies l No effects on blood pressure, electrolytes, and aldosterone in preclinical and Phase I-II clinical studies l In vitro HDL functional assays: HDL particles isolated from anacetrapib-treated patients demonstrate preserved (and possibly enhanced) cholesterol efflux properties l Dose of 100 mg selected based on PK/PD modeling: minimal dose to achieve maximal effects on HDL and LDL

47 Study Design Age: years NCEP ATPIII goal < 100 mg/dL Statin ± other lipid modifying therapy Week Visit Screening Placebo Run-in Treatment Phase Stable dose-regimen of lipid-modifying therapy R 12 week follow-up Anacetrapib 100 mg n=750 Placebo n=750 Randomization 1:1 Ratio Reversibility Phase Study drug stopped if LDL-C<25mg/dL during treatment

48 Effects on LDL-C and HDL-C LDL- C Study Week BaselineWk 6Wk 12Wk 18Wk 24Wk 30Wk 46Wk 62Wk 76 LDL-C (mg/dL) (SE) Anacetrapib Placebo Anacetrapib n = Placebo n = % (p<0.001) % (p<0.001)

49 Lipid Parameters Parameter LS Mean Percent (95% CI) Placebo-Adjusted Change from Baseline Week 24Week 76 Non-HDL-C -31.7* (-33.6, -29.8) -29.4* (-31.6, -27.3) Apo B -21.0* (-22.7, )-18.3* (-20.2, -16.4) Apo A * (42.8, 46.5) 42.3* (40.5, 44.1) TC 13.7* (12.0, 15.3) 15.6* (13.8, 17.3) TG -6.8 (-9.9, -3.9) -5.3 (-8.9, -1.7) Lp(a) (-40.7, -32.3) (-44.5, -33.9) ApoE 29.2* (24.7, 33.7) 35.3* (30.6, 40.1) *p<0.001; means for all variables except for triglycerides, lipoprotein(a), for which medians are shown

50 Anacetrapib had no effect on BP

51 l Anacetrapib treatment had robust effects on HDL-C, LDL-C, non HDL-C and Lp(a) with sustained effects over 18 months. l Anacetrapib had an acceptable side-effect profile with no effects on blood pressure, electrolytes or aldosterone. l Within the power of the study, anacetrapib did not exhibit adverse cardiovascular effects seen with a prior CETP inhibitor l The long term safety and efficacy of anacetrapib will now be tested in a large clinical outcomes trial.

52 30,000 patients with occlusive arterial disease in North America, Europe and Asia Background LDL-lowering with atorvastatin Randomized to anacetrapib 100 mg vs. placebo Scheduled follow-up: 4 years Primary outcome: Coronary death, myocardial infarction or coronary revascularization

53 All Rights Reserved, Duke Medicine 2008 Hot Science ROCKET-AF EMPHASIS-HF ASCEND-HF GRAVITAS RACE-ER REVEAL DEFINE ● 

54 PI3K Regulates  2-Adrenergic Receptor Stimulated EGFR Transactivation Kevin M. Alexander, Supachoke Mangmool, Chetan B. Patel, Kunhong Xiao, and Howard A. Rockman Duke University Medical Center Durham, NC

55 β-AR Mediated EGFR Transactivation Noma et. al. (2007) J. Clin. Invest. and Engelhardt (2007) J. Clin. Invest.

56 PI3K is Required for  2AR Mediated EGFR Transactivation EGFR Phosphorylation Src Activity  Both the lipid and protein kinase activity of PI3K are necessary for  2AR mediated EGFR transactivation.  PI3K protein kinase activity appears to lead to Src activation.  Both the lipid and protein kinase activity of PI3K are necessary for  2AR mediated EGFR transactivation.  PI3K protein kinase activity appears to lead to Src activation. β2AR stable HEK-293 cells

57 PI3K is Required for  2AR-EGFR Complex Formation Fluorescence Resonance Energy Transfer (FRET) PI3K Inhibition

58 Grow two populations of HEK-293 cells expressing HA-Src and β2AR “Light” medium “Heavy” medium LY + ISO L-Arg L-Lys HCl [ 13 C6, 15 N2 ]-L-Lys HCl (+8) [ 13 C6, 15 N4]-L-Arg (+10) ISO Mix, IP, trypsin digest, and IMAC phosphopeptide enrichment Phosphopeptide analysis by LC-MS Relative Abundance peptide A peptide B peptide C peptide D peptide E peptide F Extracted Ion Chromatogram (XIC) Light Heavy Quantification of Src Phosphorylation Using Stable Isotope Labelling with Amino Acids in Cell Culture (SILAC) Measure area under the curve

59 Sites of Src Phosphorylation by PI3K SH3 SH2

60 PI3K Regulates β2AR Stimulated EGFR Transactivation Function of PI3K in β2AR stimulated EGFR transactivation 1. Formation of PIP 3 2. Src phosphorylation

61 All Rights Reserved, Duke Medicine 2008 Agenda Hot Science Duke at the AHA Modern Communication

62 All Rights Reserved, Duke Medicine 2008 Duke At the AHA An Award Presentations Fellow Presentations LBCT & LBSS The Duke Reception

63 All Rights Reserved, Duke Medicine 2008 Award Dr. Victor Dzau receives the 2010 Research Achievement Award at the AHA Opening Sessions

64 All Rights Reserved, Duke Medicine 2008 Duke Presentations

65 All Rights Reserved, Duke Medicine 2008 Duke Presentations Saturday November 13 th 5 Sunday November 14 th 23 Monday November 15 th 57 Tuesday November 16 th 52 Wednesday November 17 th 18 Total155

66 All Rights Reserved, Duke Medicine 2008 Duke Fellow Presentations (5) Gerald BloomfieldStudying Non-Communicable Cardiovascular Diseases in sub-Saharan Africa: One Fellow's Journey Early Career: Global Cardiovascular Research Training, Opportunities and Experiences Todd Kiefer, Lawrence Park, Christophe Tribouilloy, Claudia Cortes, Riccardo Utilli, Andrew Wang Heart Failure Complicating Infective Endocarditis: An Analysis of In-Hospital Mortality from the International Collaboration on Endocarditis Prospective Cohort Study Valvular Heart Disease: Diagnosis, Pathophysiology and Medical Management II Robin Mathews, Eric D. Peterson, Anita Y. Chen, Tracy Wang, Chee T. Chin, Gregg C. Fonarow, Christopher P. Cannon, Matthew T. Roe, Karen P. Alexander Prediction of In-Hospital Major Bleeding Among Patients With Acute Myocardial Infarction: Results From 90,273 Patients in the Acute Coronary Treatment Intervention Outcomes Network Registry®- Get With the Guidelines™ (AR-G) Best of AHA Specialty Conferences Poster Session: QCOR 2010 Robb D. Kociol, Li Liang, Adrian F. Hernandez, Lesley H. Curtis, Paul A. Heidenreich, Clyde W. Yancy, Gregg C. Fonarow, Eric D. Peterson Are We Targeting the Right Economic Metric for Heart Failure? Association of Hospital 30-Day Heart Failure Readmission Rates and Total Inpatient Days Best of AHA Specialty Conferences Poster Session: QCOR 2010 Sumeet Subherwal, Eric D. Peterson, Anita Y. Chen, Richard G. Bach, Brian F. Gage, Deepak L. Bhatt, Stephen D. Wiviott, Jeffrey B. Washam, Matthew T. Roe, Karen P. Alexander, Tracy Y. Wang Is Bleeding Risk Augmented With Acute Therapies Across Increasing INR Levels Among NSTEMI Patients on Home Warfarin Therapy? Atrial Fibrillation/Arrhythmias: Epidemiology, Quality of Care and Outcomes

67 All Rights Reserved, Duke Medicine 2008 Duke Fellow Presentations (9) Chee Tang Chin, John C Messenger, Lisa A Kaltenbach, Michael A Kutcher, H Vernon Anderson, Matthew T Roe, Tracy Y Wang Comparison of Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention for Previously Stented versus De Novo Culprit Lesions: Insights from the National Cardiovascular Data Registry CathPCI Registry Acute Coronary Syndromes and Percutaneous Coronary Intervention: Quality of Care and Outcomes Sergio Leonardi, Amanda Stebbins, Renato D Lopes, Yuliya Lokhnygina, Deepak L Bhatt, Gregg W Stone, Michael A Lincoff, Harold L Dauerman, C. Michael Gibson, Harvey D White, Keyur Parick, Luis Gruberg, Howard C Herrmann, Brent T McLaurin, Shaun Goodman, Robert A Harrington, Kenneth W Mahaffey Pre-Treatment With Thienopyridines Reduces The Amount of Myonecrosis in Acute Coronary Syndrome Patients Invasively Managed: Insights from the CHAMPION trials What's New in the Treatment of Patients with Acute Coronary Syndromes? Kevin M Alexander, Supachoke Mangmool, Chetan B Patel, Kunhong Xiao, Howard A Rockman Phosphoinositde 3-Kinase Regulates β2-Adrenergic Receptor Stimulated Epidermal Growth Factor Receptor Transactivation Vascular Signaling Thomas T Tsai, John C Messenger, J Matthew Brennan, Uptal D Patel, David Dai, Robert Piana, Kevin J Anstrom, Eric L Eisenstein, Rachel S Dokholyan, Eric D Peterson, Pamela S Douglas Contemporary Risk of Follow-up Adverse Events in Older Patients with Chronic Kidney Disease and Dialysis Undergoing Percutaneous Coronary Interventions: A Report from the Merged NCDR CMS Registry The Role of Comorbidities in Cardiovascular Disease

68 All Rights Reserved, Duke Medicine 2008 Duke Fellow Presentations (14) Jonathan P Piccini, Bradley G. Hammill, Moritz F. Sinner, Paul N. Jensen, Adrian F. Hernandez, Susan R. Heckbert, Emelia J. Ben, Lesley H. Curtis Incidence of Atrial Fibrillation and Associated Mortality among Medicare Beneficiaries from 1993 to 2007 Epidemiology and Outcomes in Atrial Fibrillation Robin Mathews, Anita Y Chen, Chee T Chin, Tracy Y Wang, Kevin L Thomas, Matthew T Roe, Eric D Peterson Short- and Long-term Outcomes Among Black vs. White Patients with Non-ST-segment Elevation Myocardial Infarction Diagnosis and Outcomes Chee Tang Chin, Robert V Kelly, Mauricio G Cohen, Marc Cohen, J Richard Trout, Gregg W Stone, Jan T Christenson, Robert J Freedman Jr, Ramachandra C Reddy, Debra Joseph, E Magnus Ohman The Impact of Anticoagulation During Intra-Aortic Balloon Counterpulsation Pump Placement on In-Hospital Outcomes in 18,875 Patients Undergoing Cardiac Revascularization Heart Failure: Pacing and Other Therapeutic Devices Sergio Leonardi, L. Kristin Newby, E. Magnus Ohman, Paul W Armstrong Lack of Implementation of ESC/ACC Definition of Myocardial Infarction in Contemporary Randomized Clinical Trials From Acute Thrombotic to Chronically Occluded Coronary Arteries Zubin J Eapen, Shelby D Reed, Lesley H Curtis, Adrian F Hernandez, Eric D Peterson Do Heart Failure Disease Management Programs Make Financial Sense Under a Bundled Payment System? Heart Failure: Disease Management, Quality of Care, Anemia

69 All Rights Reserved, Duke Medicine 2008 Duke Fellow Presentations (18) Rajendra H Mehta, Jonathan P Piccini, James T Tcheng, Martin Fahy, Roxana Mehran, Gregg W Stone, On Behalf of HORIZONS-AMI Investigators Prognostic Significance of Post-Procedural Sustained Ventricular Tachycardia or Fibrillation in Patients Undergoing Primary Percutaneous Coronary Intervention: Insights from the HORIZONS AMI Trial From Acute Thrombotic to Chronically Occluded Coronary Arteries Robin Mathews, Eric D. Peterson, Shuang Li, Matthew T. Roe, Stephen D. Wiviott, Jorge F. Saucedo, Elliott M. Antman, Tracy Y. Wang Under-utilization of Emergency Medical Service Transport Among Contemporary Patients with ST Elevation Myocardial Infarction: Findings from the National Cardiovascular Data Registry ACTION - Get With The Guidelines From Acute Thrombotic to Chronically Occluded Coronary Arteries J. Matthew Brennan, Eric D Peterson, Yue Zhao, Sean O'Brien, Rachel Dokholyan, Pamela S Douglas, Fred H Edwards Predictors of Bioprosthetic Aortic Valve Failure: Results in 73,616 Patients from the Society of Thoracic Surgeons (STS) Adult Cardiac Surgery National Database Cardiac Surgery: Valvular Heart Disease (Not Including Percutaneous Valves) IV Jonathan P. Piccini, Jennifer A. White, Rajendra H. Mehta, Sana M. Al-Khatib, Pierluigi Tricoci, Charles V. Pollack Jr, Gilles Montalescot, Frans Van de Werf, C. Michael Gibson, Robert A. Harrington, L. Kristin Newby Sustained Ventricular Tachycardia and Ventricular Fibrillation are Infrequent Events but are Associated with Increased Arrhythmic and All-cause Death Following Non-ST- Segment Elevation Acute Coronary Syndromes Noninvasive Arrhythmia Testing/Risk Assessment

70 All Rights Reserved, Duke Medicine 2008 Duke LBCT & LBSS Late Breaking Clinical Trials –ROCKET-AF –ASCEND-HF Late Breaking Sciences Sessions –RACE-ER –REVEAL

71 All Rights Reserved, Duke Medicine 2008 Interviews at the DCRI Reception “The Duke Reception” Sponsors Duke Heart Center Duke Division of Cardiology Duke Clinical Research Institute Networking Current Faculty & Fellows Heart Center, Division, DCRI Staff Former Fellows Academic & Industry Collaborators

72 All Rights Reserved, Duke Medicine 2008

73 Agenda Hot Science Duke at the AHA Modern Communication

74 All Rights Reserved, Duke Medicine 2008

75 Internet Abuse Shutdown Nov 15 13:55 Hello Michael, Your server's switchport has been shutdown due to broad/multi casted traffic affecting multiple clients on our network and saturating their switchports. We request a response from you with an explanation for the large amount of traffic. If we do not receive a response in a timely manner we may need to terminate your account for violation of our acceptable use policy agreement. 44 Shows Broadcast in Real Time Duke TV Temporarily Shut Down for “Internet Abuse”

76 All Rights Reserved, Duke Medicine 2008 Dr. Hisao Ogawa reviews: ROCKET-AF and RELY, A Japanese Perspective in Japanese. Dr. Robert Harrington, Dr. Robert Califf, Dr. C. Michael Gibson present: AHA 2010 wrap-up. Dr. Robert Califf, Dr. Manesh Patel, Dr. Kenneth Mahaffey, and Dr. Keith Fox discuss: Stroke Prevention Using the Oral Direct Factor Xa Inhibitor Rivaroxaban Compared with Warfarin in Patients with Nonvalvular Atrial Fibrillation (ROCKET-AF). Dr. Matthew Price presents: Standard Versus High-Dose Clopidogrel According to Platelet Function Testing After PCI: Results of the GRAVITAS Trial. Dr. Robert Califf, Dr. Adrian Hernandez, Dr. Christopher O'Connor and Dr. Randy Starling discuss: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Dr. Clyde Yancy presents ASCEND: Historical perspective, implications for patients Failure Trial (ASCEND-HF). Dr. Anthony Furlan and Dr. Duane Pinto discuss: CLOSURE I Trial: A Prospective, Multicenter, Randomized Controlled Trial to Evaluate the Safety and Efficacy of the STARFlex Septal Closure System Versus Best Medical Therapy in Patients with a Stroke or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale.

77 All Rights Reserved, Duke Medicine 2008 Dr. Renato Lopes, Dr. Alexandre Quadros, Dr. Antonio Carlos Carvalho and Dr. Roberto Giraldez: AHA wrap-up in Portuguese. Dr. Hisao Ogawa and Dr. Yoshihiko Saito: An AHA 2010 wrap-up in Japanese. Professor Murray Esler and Dr. Duane Pinto discuss: Symplicity HTN-2: International, Multicenter, Prospective, Randomized, Controlled Trial Of Endovascular Selective Renal Sympathetic Denervation For The Treatment Of Hypertension. Dr. Jonathan Piccini and Dr. Duane Pinto discuss: Sustained Ventricular Tachycardia and Ventricular Fibrillation Are Infrequent Events but are Associated with Increased Arrhythmic and All-Cause Death Following Non-ST-Segment Elevation Acute Coronary Syndromes. Dr. Stephen Nicholls and Dr. Ravi Karra discuss the results of the ASSERT study, the first major clinical trial of an oral agent inducing Apo A1 synthesis: A new approach to HDL raising and CV risk modification. Dr. Magnus Ohman and Dr. C. Michael Gibson discuss LVADs: Improving Outcomes. Dr. Matthew Brennan and Dr. C. Michael Gibson discuss: Anticoagulation Following Bioprosthetic Aortic Valve Replacement.

78 All Rights Reserved, Duke Medicine 2008 Dr. Christopher Granger, Mayme Roettig, RN, MSN, and Dr. Ravi Karra discuss: Mission Lifeline Update Dr. Peter Kowey provides and expert opinion on ROCKET AF and RELY. Dr. Robert Harrington presents: Beyond 2010, The Future of Antithrombic Therapy - Old Agent Replacement, Combination Therapy, and the Impact of Generics. Dr. Kristin Newby and Dr. Duane Pinto discuss: An EARLY-ACS Update. Dr. Chistopher Cannon presents: Primary Results of the DEFINE trial: Determining the EFficacy and Tolerability of CETP INhibition with AnacEtrapib. Dr. Peter Kowey discusses: Efficacy And Safety Of Prescription Omega-3-Acid Ethyl Esters (P-OM3) For The Prevention Of Recurrent Symptomatic Atrial Fibrillation (AF). Dr. Magnus Ohman reviews: TRILOGY: An Update. Dr. Karen Alexander and Dr. Duane Pinto describe: The Coming Tsunami: Cardiovascular Disease in the Elderly.

79 All Rights Reserved, Duke Medicine 2008 Dr. Tracy Wang and Dr. Duane Pinto discuss: Under-Utilization of Emergency Medical Service Transport Among Contemporary Patients with ST-Elevation Myocardial Infarction – Findings from the National Cardiovascular Data Registry ACTION, Get with the Guidelines. Dr. Sara Pasquali and Grendel Burrell discuss: The Impact of Intensive Care Unit Structure on Post-operative Outcomes Following Congenital Heart Surgery: Analysis of a Multi- institutional Database. Dr. Jennifer Li, Dr. C. Michael Gibson, and Grendel Burrell discuss: Lessons from Pediatric Cardiovascular Drug Trials. Dr. Dominick Angiolillo presents: Commentary on GRAVITAS. Dr. Christopher Granger and Dr. Ravi Karra discuss: Reperfusion of Acute Myocardial Infarction in Carolina Emergency Departments - Emergency Response (RACE-ER) Project. Bradi Granger RN, PhD and Dr. Ravi Karra discuss: The Duke Translational Nursing Institute. Dr. Otavio Berwanger and Dr. Duane Pinto discuss: Acetylcystein for the Prevention of Contrast-Induced nephropaThy (ACT) Trial: a Pragmatic Multicenter Randomized Trial to Evaluate the Efficacy of Acetylcysteine for the Prevention of Renal Outcomes in Patients Undergoing Coronary and Vascular Angiography.

80 All Rights Reserved, Duke Medicine 2008 Dr. Christoph Kaiser and Dr. Duane Pinto discuss: The BASKET PROspective Evaluation Examination (BASKET PROVE): Late Cardiac Clinical Death and Myocardial Infarction Associated With Late Stent Thrombosis in Large Vessel Stenting After 1st or 2nd Generation Drug-eluting Compared to Bare-metal Stents. Dr. William Weintraub and Dr. Ravi Karra discuss: Top 100 Vocabulary Project. Dr. Richard Becker and Dr. Ravi Karra discuss: Pathways in Anticoagulation: What's Most Efficacious, Safest. Karen Pieper and Dr. Duane Pinto present: Insights from Plato: Proton Pump Inhibitor Use Is Likely a Marker for, Rather than a Cause of, a Higher Risk of Cardiovascular Events. Dr. Thomas Povsic and Dr. Duane Pinto discuss: A Prospective RADAR Pharmacokinetic and PharmacodynamicSubstudy: Pegnivacogin (RB006), a Direct Factor IXa Inhibitor, Results in Consistent and Near Complete Inhibition of Factor IX Activity in Patients with Acute Coronary Syndromes. Dr. Sunil Rao and Dr. Ravi Karra discuss: The Primary Results of the REVEAL Trial: A Randomized Placebo Controlled Trial of Intravenous Erythropoietin to Reduce Infarct Size After ST-Segement Elevation Myocardial Infarction.

81 All Rights Reserved, Duke Medicine 2008 Dr. Kristin Newby and Dr. Duane Pinto discuss: MURDOCK Study Progress and Substudies. Dr. Keith Aaronson and Dr. Duane Pinto discuss: Evaluation of the Heartware HVAD Left Ventricular Assist Device System for the Treatment of Advanced Heart Failure: Results of the ADVANCE Bridge to Transplant Trial. Dr. James Daubert and Dr. Duane Pinto discuss: QTc Prolongation During Therapeutic Hypothermia: Does it Deserve Attention? Dr. David Cohen and Dr. Duane Pinto discuss: PARTNER Trial (Cohort B): Health-Related Quality of Life After Transcatheter Aortic Valve Implantation vs. Non-Surgical Therapy Among Inoperable Patients With Severe Aortic Stenosis. Dr. Karen Alexander discusses: Frail Older Adults at Risk for Loss of Independence Following MI. Dr. Kenneth Ellenbogen and Dr. Duane Pinto discuss: SMART AV: Comparison of AV Optimization Methods Used in Cardiac Resynchronization Therapy (CRT). Dr. Deepak Voora and Dr. Duane Pinto discuss: A Whole Blood RNA Signature Accurately Classifies Multiple Measures of Platelet Function on Aspirin in Healthy Volunteers and Highlights a Common Underlying Pathway.

82 All Rights Reserved, Duke Medicine 2008 Dr. James Januzzi and Dr. Duane Pinto discuss: PROTECT: Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting. Dr. Chris O'Connor, Dr. Randy Starling, and Dr. Clyde Yancy provide historical perspective and discuss the results/implications for ASCEND. Dr. Christopher O'Connor and Dr. Zubin Eapen discuss Duke's Presence at AHA, What's Happening, What to Expect. Dr. Rob Califf talks with Dr. Zubin Eapen about a Cardiology Fellow's Perspective from AHA 2010.

83 All Rights Reserved, Duke Medicine 2008

84 Daily Heart Line Memos From Chris & Marti

85 All Rights Reserved, Duke Medicine 2008 Post-Test Question Question: What was the most important advance by Duke Heart Center faculty or fellows from the AHA? Answer Options: ROCKET-AF ASCEND RACE-ER The Duke Cardiology Fellows Blog DUKE-TV

86 All Rights Reserved, Duke Medicine 2008 Post-Test Question Question: What was the most important advance by Duke Heart Center faculty or fellows from the AHA? Answer Options: ROCKET-AF ASCEND RACE-ER The Duke Cardiology Fellows Blog DUKE-TV

87 John H. Alexander, MD Director, Heart Center SBR Co-Director, DCRI CV Research Thank You! Have a Happy Thanks Giving! Cardiology Grand Rounds November 23, 2010


Download ppt "John H. Alexander, MD Director, Heart Center SBR Co-Director, DCRI CV Research American Heart Association Update “Highlights of the AHA” “Duke at the AHA”"

Similar presentations


Ads by Google