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Antiretroviral drugs in UMMC Presenter: TE CHIN YEW Preceptor: KHOO SU LIN.

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Presentation on theme: "Antiretroviral drugs in UMMC Presenter: TE CHIN YEW Preceptor: KHOO SU LIN."— Presentation transcript:

1 Antiretroviral drugs in UMMC Presenter: TE CHIN YEW Preceptor: KHOO SU LIN

2 Treatment goal reduce HIV-associated morbidity and prolong the duration and quality of survival, restore and preserve immunologic function, maximally and durably suppress plasma HIV viral load, and prevent HIV transmission.

3 Life cycle of HIV and targets for antiretroviral drugs.

4 1 NNRTI/ 1 PI 2 NRTI 1 st line

5 Nucleoside Reverse Transcriptase Inhibitor Lamivudine, Zidovudine, Stavudine, Tenofovir

6 Lamivudine (3TC) 150mg BD Brand name: 3TC OP

7 Zidovudine (AZT) 300mg BD Brand name: Zidovudine Side effects: Bone marrow suppression: macrocytic anemia/neutropenia; GI intolerance, headache, insomnia, asthenia OP

8 Stavudine (d4T) 30mg BD Brand name: Stavudine Capsules USP Side effects: Peripheral neuropathy, lipodystrophy, panreatitis, lactic acidosis with hepatic steatosis, hyperlipidemia OP

9 Tenofovir 300mg OD Brand name: Tenvir Side effects: asthenia, headache, diarrhea, nausea, vomiting, flatulance, renal insufficiency Kedai PharmUMMC

10 Nonnucleoside Reverse Transciptase Inhibitors Efavirenz, Nevirapine

11 Efavirenz (EFV) 600mg ON Brand name: Stocrin Side effects: rash, CNS symtoms (insomnia, irritability, lethargy, dizziness, vivid dreams), increase LFT OP

12 Nevirapine (NVP) 200mg BD Brand name: Nevirapine Tablets USP Side effects: rash including Steven-Johnson Syndrome, symptomatic hepatitis (including fatal hepatic necrosis) OP

13 Kaletra, Indinavir, Ritonavir, Darunavir, Atazanavir Protease Inhibitors

14 Indinavir 800mg TDS Brand name: Crixivan Side effects: Nephrolithiasis, GI intolerance, nausea, hyperlipidemia, headache, asthenia, blurred vision, dizziness, metallic taste, thrombocytopenia, alopecia, hyperglycemia, fat maldistribution OP

15 Ritonavir 600 mg BD Brand name: Norvir Side effects: GI intolerance, nausea, diarrhea, paresthesias, hyperlipidemia, hepatitis, asthenia, hyperglycemia, fat maldistribution Kedai PharmUMMC

16 Darunavir 600mg BD Brand name: Prezista Side effects: skin rash, diarrhea, nausea, headache, hyperlipidemia, hyperglycemia, fat maldistribution Kedai PharmUMMC (Study)

17 Atazanavir 400mg OD Brand name: Reyataz Side effects: prolonged PR interval, hyperglycemia, fat maldistribution Kedai PharmUMMC (Study)

18 Integrase Inhibitor Raltegravir

19 400 mg BD Brand name: Isentress Side effetcs:headache, fatigue, dizziness, pruritis Kedai PharmUMMC

20 Combination drugs

21 Zidovudine + Lamivudine 1 tab BD Brand name: Combivir OP

22 Tenofovir + emtricitabine (Truvada) 1 tab OD Brand name: Tenvir-EM Kedai PharmUMMC

23 Lopinavir + ritonavir 2 tabs BD Brand name: Kaletra Kedai PharmUMMC

24 Stavudine + Lamivudine + Nevirapine 1 tab BD Brand name: SLN OP

25 LASA

26 References: Marie A. Chisholm-Burns, et. al Pharmacotherapy principles & practice. Mc. Graw Hill. Department of Health and Human Services (DHHS)( Guidelines. (http://aidsinfo.nih.gov)http://aidsinfo.nih.gov PPUM Drug Formulary


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