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Understanding the “Silent” Disease: Pancreatic Cancer

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Presentation on theme: "Understanding the “Silent” Disease: Pancreatic Cancer"— Presentation transcript:

1 Understanding the “Silent” Disease: Pancreatic Cancer
Tara Woodard

2 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

3 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

4 Top 5 Deadliest Cancers: 2010 Expected Deaths:
1) Lung and bronchial cancer ( > 157,000 ) 2) Colon and rectal cancer ( > 51,000 ) 3) Breast cancer ( 40,000 ) 4) Pancreatic cancer ( 37,000 ) 5) Prostate cancer ( 32,000 ) Top 5 Deadliest Cancers: 2010 Expected Deaths:

5 American Cancer Society estimated >42,000 cases in 2009
Statistics from :

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7 5 Year Survival from 2001-2007: In 2008, >35,000 deaths
(compare to 40,930 deaths in 2008 from breast cancer) 5 Year Survival from :

8 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

9 Anatomy & Function of the Pancreas:
Spongy, 6-inch-long organ located behind the stomach. Produces digestive enzymes. Produces hormones that regulate the body’s use of starches and sugars. Anatomy & Function of the Pancreas:

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12 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

13 More than 95% of all pancreatic cancer begins in the exocrine pancreas.
Less than 5% begins in the endocrine pancreas. Main Types:

14 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

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17 Pancreatic Cancer: Carcinogenesis

18 Unique Characteristics:
The genetic basis is extremely complex and heterogeneous An average of 63 genetic abnormalities per tumor = individualized treatment. Unique Characteristics:

19 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

20 Risk Factors: You are at an increased risk if you: Are over 60
Are overweight or obese Have diabetes Smoke Have a family history of Pancreatic Cancer Are African American Have chronic inflammation of the pancreas blood type A, B, or AB Risk Factors:

21 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

22 Signs & Symptoms for Endocrine:
Abdominal Pain Stomach Pain Diarrhea Fatigue Fainting Weight gain Signs & Symptoms for Endocrine:

23 Signs & Symptoms for Exocrine:
Vague sporadic discomfort Upper abdominal or lumbar pain which worsens at night Back pain aggravated by lying flat, relieved when sitting up Radiating pain to the back Pain occurring several hours after eating Loss of appetite Weight loss Jaundice Depression Signs & Symptoms for Exocrine:

24 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

25 Tests for Diagnosis: Transabdominal ultrasound Endoscopy Ultrasound
Angiogram Biopsy CT scans Endoscopic Retrograde Cholangiopancreatogram (ERCP) Elevated blood levels of bilirubin Tests for Diagnosis:

26 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

27 Staging for Endocrine:
Gastrinoma Insulinoma Miscellaneous Recurrent Staging for Endocrine:

28 Staging for Exocrine: Stage 1A: Tumor found only in pancreas, ≤ 2cm
Stage 1B : Tumor found only in pancreas, > 2cm Stage 2A : Cancer spread to nearby organs but does not involve celiac axis or superior mesenteric artery Stage 2B : Cancer spread to regional lymph nodes Stage 3 : Cancer spread to celiac axis or the superior mesenteric artery Stage 4 : Distant metastasis Staging for Exocrine:

29 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

30 The Prognosis: Still considered largely incurable.
Low survival rates are most likely due to: < 10% of patients' tumors are confined to the pancreas at time of diagnosis Progressed malignancy The Prognosis:

31 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

32 Diets that are Thought to Help:
Increase in cruciferous vegetables (cabbage), Folic acid, and Vitamin C. (A) Alpha-lipoic acid (PA) Curcumin (PS) Genstein (A) Green tea (A) limonene (P) Melatonin (A) Mistletoe (PSA) Omega-3 fatty acid (S) Probiotics (P) Selenium [P= preventative, A= anticancer, S= supportive] Diets that are Thought to Help:

33 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

34 Surgery: When tumors can be removed
Can remove all, or part of the pancreas Whipple procedure. Long term survival: 15-20% with a median survival rate of around months. Recurrence is about 85% Surgery:

35 Uses radiation in order to damage the cancer cells and prevent them from growing.
This is given 5 days a week, for 5-6 weeks. Side effects: nausea, vomiting, and diarrhea. Radiation Therapy:

36 Chemotherapy: Kills cells that are growing or multiplying.
Given in cycles: Treatment, followed by recovery. Side effects: More likely to get infections, hair loss, digestive problems including nausea and vomiting. Chemotherapy:

37 Biological Therapy/ Immunotherapy:
Designed to restore the patients immune system. BRMs Side effects: flu-like symptoms, nausea, vomiting, and diarrhea. Biological Therapy/ Immunotherapy:

38 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

39 New targeted agents are in clinical development, including:
Small-molecule inhibitors of oncogenes and signaling pathways Monoclonal antibodies targeting cell-membrane proteins Nanotechnology and adenoviral agents The Future:

40 Content of Pancreatic Cancer Tutorial:
Statistics in the US Function of the Pancreas Types of Pancreatic Cancer An Overview of Pancreatic Cancer Who’s at Risk Signs/Symptoms Tests Staging Prognosis Diets Treatments Future of Pancreatic Cancer References Content of Pancreatic Cancer Tutorial:

41 http://www. medicinenet
“Choices- The Most Complete Sourcebook for Cancer Information.” Morra, Potts. 4th Edition. Harper Collins Publishers Inc. New York, NY. Oct 2003. “The Definitive Guide to Cancer- An Integrative Approach to Prevention, Treatment, and Healing.” Alschuler, Fabno, Gazella. 3rd Edition. Random House, Inc. New York InnoVision Health Media. References:


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