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As A Biotherapeutic Agent In Clinical Nutrition.  Microbial Cell Preparation  Efficacy Established  Scientifically Proven Safe For Consumption  Palatable.

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Presentation on theme: "As A Biotherapeutic Agent In Clinical Nutrition.  Microbial Cell Preparation  Efficacy Established  Scientifically Proven Safe For Consumption  Palatable."— Presentation transcript:

1 As A Biotherapeutic Agent In Clinical Nutrition

2  Microbial Cell Preparation  Efficacy Established  Scientifically Proven Safe For Consumption  Palatable Flavour  No Reported Side Effect  Registered With National Pharmaceutical Control Bureau Control Bureau

3 ABSORPTIONABSORPTION CLINICALNUTRITIONCLINICALNUTRITION IMPROVEQOLIMPROVEQOL

4 & Constipation

5 Pathophysiology of Constipation

6 Aged Population Pregnant Mothers Bed Ridden Patients Premature Babies Vulnerable Groups Travelling Individual Medication Stress Laxative Abuse

7 Hemorrhoids Anal fissure Diarrhea Fecal incontinence Rectal bleeding Rectal prolapse Rectal hernia Fecal impaction Uterine hernia Uterine prolapse Prolonged Constipation May Lead To:

8 Prolong Constipation: Hemorrhoids

9 Rectal Prolapse Rectal Bleeding Anal Fissure Uterine Prolapse

10 Hexbio  Improves Chronic Constipation

11 Number of patients according to gender The study of “Efficacy of in Improving Chronic Constipation” was conducted in 12 patients consisting of 5 males and 7 females. Figure shows the total of patients (N) involved in the study according to gender.

12 Years of constipation Age of patients Chart shows the age of the patients ranging from 22 to 83 years old and the years each patients suffer from constipation ranging from 2 to 31 years. Age of patients and years of constipation years

13 Results Above graph shows the frequency of stools during the study period of 7 days. According to the results, stool frequency increased from 1.4 time a week before treatment to 4.3 a week after treatment. This indicates the efficacy of in increasing patients’ bowel movement and reduces constipation. Above graph shows the frequency of stools during the study period of 7 days. According to the results, stool frequency increased from 1.4 time a week before treatment to 4.3 a week after treatment. This indicates the efficacy of in increasing patients’ bowel movement and reduces constipation. Stool frequency per week p = Stool frequency

14 Role of Probiotic Mixture In Treatment Of Childhood Constipation The probiotic mixture was contained Bifidobacterium and lactobacillus. Frequency of Bowel Movement (BM) per week in 20 children we tested. According to the chart, the frequency of BMs in overall children increased in each week showing that the administration of probiotic mixture had a positive effect on frequency of BM. The role of probiotics mixture in the treatment of childhood constipation : a pilot study. Noor-L-Huada Bekkali, Marloes EJ Bongers, Maartje M Van den Berg, Olivia Liem and Marc A Benniga. Netherlands. Published in 4 August Frequency of Bowel Movement

15 A study to determine the prevalence of IBS and to assess the symptoms subgroups in young adult Malaysians was done. The results obtained had been categorized into few subgroups of symptoms as shown above. As conclusion, within the IBS population, the majority (77.4%) was of the constipation-predominant IBS subgroup. Prevalence of irritable bowel syndrome in young adult Malaysians: A survey among medical students. Tan, Yan-mei; Goh, Khean L; Muhidayah, Raja; Ooi, Chee L; Salem, Omar. Department of Medicine, Faculty of Medicine, University of Malaya. Prevalence of Irritable Bowel Syndrome on young adult. Malaysian: A survey among Medical Students

16 HOW HELP CONSTIPATION???

17 Bekkali et. al. (2007). The role of probiotics mixture in the treatment of childhood constipation: a pilot study. Nutrition Journal 6: 17.  Secretes organic acids, maintaining acidic environment that induce peristalsis.  Regularize bowel movement and shortens the Colonic Transit Time.Mechanism of Action ProvideAcidicEnvironment InducePeristalsisIncrease Bowel Movement Frequency Shorten Colonic Transit Time FacilitateSmootherDefecation

18 & Diarrhea

19 Is Like A Storm Raging Inside You & Its Shows Up At The Most Unexpected Time

20 Diarrhea Frequent loose or liquid bowel movements, often due to disruption of water absorption in the colon

21 Defense Mechanism  In the event of pathogenic infection, diarrhea functions as an evolved expulsion defense mechanism.  The appendix serves as a safe house for the good bacteria, protecting it from contamination and facilitating a re-start of the system once the contaminating organisms has been eliminated.

22 TypeConditionCausedEfficacy, HEXBIO ®SecretoryDiarrhea Increase secretion activity or inhibition of absorption. 1.Cholera toxinN.A. OsmoticDiarrhea Too much of water is drawn into the bowel, maldigestion. 1.Osmotic laxatives 2.Malabsorption 3.Lactose intolerance Selective Motility-RelatedDiarrhea Rapid movement of food through the intestines (hypermotility). 1.Menstruation 2.Hyperthyroidism N.A. InflammatoryDiarrhea Damage to the mucosal lining, which leads to a passive loss of protein- rich fluids, and a decreased ability to absorb these lost fluids. 1.Bacterial/ viral/ parasitic infection 2.Inflammatory bowel disease 3.Antibiotic treatment 4.Colon cancer Most Types of Diarrhea

23 Treatment of Acute Gastroenteritis in Infants (6-12 months) Raanan Shamir et. al, Evaluation of a diet containing probiotics for the treatment of mild diarrheal illness in children younger than one year of age, American College of Nutrition 2005; 24(Suppl. 5): From the study, 65 young children aged 6-12 months, suffering from acute gastroenteritis were treated daily until diarrhea resolution. As showed in the result, the feeding of microbial cell preparation reduced the severity and duration of acute gastroenteritis in young children.

24 61 children that tested positive for rotavirus were treated with microbial cell preparation/placebo for 6 days. Stools were collected and examined again after 6 days of treatment. In conclusion, oral administration of microbial cell preparation is effective in reducing the duration of rotavirus excretion. Guarino A et. al, Oral bacterial therapy reduces the duration of symptoms and of viral excretion in children with mild diarrhea, Department of Pediatrics, University Federico II of Naples, Italy

25  The largest meta-analysis to evaluate 34 different clinical trials involving 4844 patients.  Result:  Reduced the likelihood of developing antibiotic- associated diarrhea by 52%. Reduce Incidence of Antibiotic Associated Diarrhea Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:  Conclusion:  The benefits were most pronounced among children.

26  An analysis to evaluate 34 different clinical trials involving 4844 patients.  Result:  Reduced the incidence of acute diarrhea by 34%.  Review:  In 12 pediatric studies included in this analysis, it reduced the likelihood of acute diarrhea in children by 57% (p<0.001) Reduce Incidence of Acute Diarrhea Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomized, placebo-controlled trials. Lancet Infect Dis. 2006;6:  Conclusion:  The benefits were most pronounced among children.

27 Combined Treatment (with ORS) of acute diarrhea in children 37 children aged 3 to 24 months received ORS as a form of rehydration, and were treated to microbial cell preparation at 12-hours interval until the resolution of diarrhea. In conclusion, addition of microbial cell preparation to ORS was effective in the treatment of children with acute diarrhea by decreasing the duration of diarrhea. 37 children aged 3 to 24 months received ORS as a form of rehydration, and were treated to microbial cell preparation at 12-hours interval until the resolution of diarrhea. In conclusion, addition of microbial cell preparation to ORS was effective in the treatment of children with acute diarrhea by decreasing the duration of diarrhea. Simakachorn N. et. al, Clinical evaluation of the addition of lyophilized Lactobacillus LB to oral rehydration therapy in the treatment of acute diarrhea in children, Journal of Pediatric Gastroenterology and Nutrition

28 Hexbio ® + ORS Gilliland et. al. (2001). Health and nutritional properties of probiotics in foods including powder milk with live Lactic Acid Bacteria, WHO/FAO

29 HOW HELP DIARRHEA???

30 Mechanism of Action Produce anti-microbial substances Neutralize enterotoxins from pathogen Reduce rotavirus shedding Suppress the replication of virus Secretes lactase enzyme Facilitate digestion of lactose  Neutralize enterotoxins from pathogens.  Produce anti-microbial substances to suppress the growth of pathogens.  Reduce rotavirus shedding.

31 & Immunity

32  Common Cold – upper respiratory tract infection caused by either rhinoviruses or coronaviruses.  Flu – infectious disease caused by Influenza viruses. Cold and Flu

33 HOW HELP to induce immunity???

34  Induces secretion of Immunoglobin A.  Increase level of T-Lymphocyte cells as well as other helper immune cells.  Activate the human myeloid dendrite cell (MDC) to induce immune response. Mechanism of Action Immunostimulation of mucosal membrane Increase Synthesis of IgAIncreaseT-Lymphocytes Activate MDC

35 Stimulation of T-Lymphocyte Level G. Perdigon et. al, Symposium: Probiotic bacteria for humans: Clinical systems for evaluation of effectiveness, Journal of Dairy Science : Consumption of microbial cell preparation able to stimulate the level of T-Lymphocyte cells.

36 Reduction of Cold and Flu Symptoms  For 6 months, 326 children, aged 3 to 5 were treated twice a day.  Results: Probiotic Effects on cold and influenza-like symptom incidence and duration in children. American Academy of Pediatrics SymptomsIncidence Rate Treatment Group Control Group Cough29.5%83.7% Fever16.1%63.5%  Microbial cell preparation reduces the incidence and severity of cold and flu symptoms in children.

37 & Other Diseases

38 STROKE

39 Chart shows the overall rates of complications in the Asian region. Among the non- neurologic complications, the most commonly encountered were chest infections, constipation and urinary retention with a rate of 19%, 15% and 11% respectively. Complication of Acute Stroke : A study in Ten Asian countries. Jose C.Navvaro MD MSc et.al, Neurology Asia 2008; 13: University of Santo Thomas, Espana, Manila, Phillipines.

40 DIABETES

41 Gastrointestinal Symptoms associated to Diabetic Complications. Scientist state that 76% of DM patients undergo at least one gastrointestinal problem and the majority of them suffer from constipation. The percentage are as shown below:- DIABETES TYPE 1 Is a failure of the pancreas to produce insulin TYPE 2 Is insulin resistance or impaired glucose tolerance

42 Diabetes Related GIT Symptoms Irritable Bowel Syndrome Constipation Dyschezia (Painful Defecation) Diarrhea Fecal incontinence Dyspepsia (Upset Stomach, Indigestion) Nausea /vomiting Heartburn

43 The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 1 compared to respective control. As showed above, the highest symptom stand of peripheral neuropathy for muscle numbness, continued by dyspepsia and constipation which holds the third place with percentage of 16.7%.

44 The chart pie above shows the prevalence of GI tract symptoms among patients with DM type 2 compared to respective control. As showed above, the highest symptom is peripheral neuropathy with 51.6%, continued by heartburn 19.8%, dyspepsia 13.4% and constipation 10.1%.

45 COLON CANCER

46 DEFECATION.. Is not evaluated according to HOW MANY times we defecate.. It is evaluated according to the TYPES of stool that been eliminated.. Types of Stool Evaluation Of Stool

47 Constipation Normal Diarrhea Bristol Stool Chart

48 Bowel Movement (BM) Frequency and Risk of Colorectal Cancer in a Large Cohort Study of Japanese Men and Women IRR BM Above chart shows the average Incidence Rate Ratios (IRR) for colorectal and colon cancer according to BM frequency. As shown, it is the best to have BM every 2-3 days as it shows the lowest IRR. Too often of BM per day can cause higher risk of colon and colorectal cancer. This is the same with BM every 6 days or less which has IRR of 1.81 average for both men and women. British Journal of Cancer (2004) 90,

49 Colon Cancer

50

51 Safety  Acute Oral Toxicity Test for Hexbio  was done in TÜV SÜD PSB Singapore to find out the Adverse Effect of Hexbio.  Necropsy Result shows there is no weight & colour change of the liver. SafetySafety

52 Nutrition Fact ContentUnit Protein gram per sachet 0.16 Fat gram per sachet 0 Fiber gram per sachet 0 Carbohydrate gram per sachet 2.7 Calories gram per sachet 11.6 * Hexbio ® * Hexbio ® is safe for all type of patients’ consumption since the Carbohydrate and the Calories are in the safe range for everybody

53 Sleeping Activity Appetite Psychology Hexbio In Balancing QOL When there is Constipation; Diarrhea; Cold or Flu Our normal daily activities (as mentioned) will be disturbed. Hexbio is here to overcome the symptoms and improve the Quality of Life!

54 HOW TO USE ? WHEN TO USE ?

55 Consume: 1 sachet during each meal BreakfastBreakfast DinnerDinner As a good treatment; For good absorption of nutrients; and for faster recovery Hexbio can function at BOTH small intestine & large intestine

56 2. Liquid Dose 1 sachet (3g) to 5ml water/juices/energy drinks/milk Pour 1 sachet into 5ml water Stir to mix Feed using syringe 1. Oral Dose Consume 2 sachets during Breakfast & Dinner each by directly pour into the mouth Dosage

57 Before any patient been discharged, it is very important for a Medical Practitioner to ensure that the patient’s bowel movement is smooth and able to have good absorption of nutrient, for a promising RECOVERY!

58 Thank You! B-CROBES MARKETING (M) SDN. BHD.


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