Presentation on theme: "Porcine Epidemic Diarrhea Virus (PEDV) Status & Research Update"— Presentation transcript:
1Porcine Epidemic Diarrhea Virus (PEDV) Status & Research Update Lisa Becton, DVM, MS, DACVPMDir. Swine Health Info & ResearchNational Pork Board
2PEDV status world-wide PEDV is currently active and considered endemic in different parts of the world (China, Japan, South Korea, Thailand, Vietnam – Pacific rim countries).Canada had first positive cases in January 2014Different strains identified in the U.K. (1970s) that did not appear as pathogenic as the Chinese strainsOther countries with cases: Germany, Spain, France, Mexico, Colombia; Ecuador, Ukraine, PeruPEDV is considered to be a production disease.Primary management tools within the U.S. = focus on targeted biosecurity efforts.Killed vaccines are approved for use in the U.S. (two currently approved).
8Research for PEDV & PDCoV 2013~$1 million for researchFunded 14 projectsBasics of diseaseSow immunity (initial work)Foundation for biosecurity2014~$2 million for researchFunded 35 projectsFeed focusAnimal focusBiosecurity validationDisease monitoring
9PEDV Research Priorities Basic Research of PEDV:Who - What - Where - When - Why - How…Diagnostic test developmentBasics of disease transmission and survivabilitySow immunity: (project duration ~ 12 months)Duration of immunityOptimizing feedback protocolsDiagnostic tests to assess sow and piglet immunity to PEDV
10PEDV/PDCoV Research For 2014 Research priorities – 2014:Feed Focus:Risk assessment for feed as transmission sourceIntervention methods for feed (pelleting/additives)Post-processing time on virusNovel bioassay modelsBiosecurity ValidationAnimal Focus:PEDV immunity developmentPDCoV = pathogenicity & diagnostic test development
11PEDV/PDCoV Research For 2015 Hone in on more specifics of development, duration and optimization of sow immunity (based on 2013/2014 work)Feed interventions (based off of info from 2014)Novel vaccine administration technologies
12Basics of virus survival - What have we learned? Survivability of the virusPEDV can survive in many different conditions:Pits; feed slurry; manure; water – fresh and recycle; feed ingredientsSurvive in cold conditionsSurvivability in pits can be time dependentPEDV + PCR found at 4 & 6 monthsPEDV bioassay only + for 4 month
13Key MessagesPEDV survives for extended time in various substances = clean/disinfect for best controlFor pit/manure management:Work at farms with longest time since infection first, and farms most recently infected lastCommunication x 10 with all parties involved!!
14Transportation - What have we learned? Transportation management is critical!!!Certain procedures for trucks can kill the virus:160˚F for 10 minutes kills PEDV68˚F for 7 days kills PEDVClean, disinfect and heat (see above) can kill PEDV and other pathogens!Quaternary ammonium/gluteraldehydeAccel – hydrogen peroxide mixOthers… (bleach; phenolics etc.)
15Key Messages Prevent contamination as much as possible. Create a “Line of Separation”Keep clean and dirty equipment separateAvoid contamination of high risk areasFocus on removal of organic material for effective cleaning and disinfection.Goal = reduce the virus load on equipment
16Identify the “Line of Separation” No cross traffic at this point !
18Feed/Feed Systems - What have we learned? Feed managementTakes a very small amount of virus to infect pigs!Some potential products can help to eliminate virus in feedFormaldehyde based; medium chain fatty acids; essential oilsAssessment of pelleting and heat treatment may be effective for point-in-time virus control
19Immunity - What have we learned? Immunity to the virusWe now have many different diagnostic tools to detect PEDV:Can detect the virus (PCR)Can detect exposure to the virus (ELISA or IFA)Can evaluate the level of immunity to the virus (FFN, IFA)Basics of immunity:Gut immunity is needed for protectionPiglets need to consume milk to be protected against PEDVThe response to PEDV can vary by sow and so can protection passed to piglets
20Immunity - What have we learned? Immunity to the virusSows do respond to feedback and develop antibodiesOral exposure is best but exposure also causes clinical illnessVaccines can help, but killed products may not have enough foreign protein to stimulate immunitySow immunity:Immunity has been seen for at least 6-7 monthsWork being done on cross-protection and some degree of protection may be happeningWill use results of these studies for continuation of work for 2015*
21Communication of Research Results Provide producers with “real-time” resultsCreated a PEDV-specific site for all informationResearch updates available bi-weekly until project completion ; See for biweekly updates
22How do we get better prepared for the “next time”?
23Emerging Diseases of Swine Examples of recent emerging diseases of concern:Porcine Circovirus Type 2b (China)PEDVPorcine kubovirus
24NPPC 2014 Resolution NPPC Forum Resolution 2014: A proposed plan of coordination and program execution for the US Swine Industry in the event of the identification/introduction of any new economically significant swine disease (defined as not currently identified in the United States as of March 1, 2014).This shall include all possible non-reportable diseases which may afflict swine
25Working on Our Preparedness Response PlanNPPC is managing in 2015Coordinated state-federal-industry responseSwine Matrix Project = Identifying “What’s next?”AASV is managing in 2015Will need research and updatingSwine disease information sharingNPB is managing in 2015Swine Health and Information CenterTo address these concerns about how to better address future emerging diseases NPPC passed a wide-ranging resolution at this spring’s Pork Forum.It was a multi-part resolution – including developing a plan in the event of new economically significant swine diseases. T
26Response Plan – NPPC Focus Working with industry and government partners to provide input and guidance for an emerging disease response planOutline clear responsibilities for all partiesHave that available to all parties for useHave had several in-person meetings and document is becoming finalized
27Swine Disease Matrix project Identify “what’s next”?Use both US and global surveillance of literature, reports, other info for diseases of potential interestLiterature search on targeted diseasesIdentify basic knowledge gapsFocus resource deploymentDevelop a one pager on prioritized diseasesWork with government partners (federal and state)Determine roles and outcomes –Define who handles data, confidentiality, disease control measures?
28Key Points Focus on global production diseases Establish a mechanism for evaluating disease implications and prioritizing threatsWork towards recognizing and filling resource/knowledge gapsEstablish a diagnostic/surveillance system that searches for the introduction of emerging diseases
29Expert Working Group Patrick Webb - NPB Joe Connor - Practitioner Doug MacDougald – Practitioner (Canada)Kent Schwartz – ISU VDLEric Bush – USDA EpidemiologistDick Hesse – KSU VirologistJane Christopher-Henning – SDSU VDLMike McIntosh – USDA FADDLDermott Hayes – Ag EconomistKurt Rossow – MN VDLJohn Waddell – AASV SHC ChairHarry Snelson – AASVMark Engle – WG Chair (unable to attend)
31Swine Health and Information Center MissionTo protect and enhance the health of the US swine herd throughtargeted research investments that minimize the impact of future disease threats;collection and analysis of swine health dataglobal disease monitoring.To address these concerns about how to better address future emerging diseases NPPC passed a wide-ranging resolution at this spring’s Pork Forum.It was a multi-part resolution – including developing a plan in the event of new economically significant swine diseases. T
32Swine Health and Information Center OperationsWork in synergy with the National Pork Board, the National Pork Producers Council, and the American Association of Swine VeterinariansAdd to and not duplicate the capabilities of the associationsLocationVirtual “Center”To address these concerns about how to better address future emerging diseases NPPC passed a wide-ranging resolution at this spring’s Pork Forum.It was a multi-part resolution – including developing a plan in the event of new economically significant swine diseases. T
33Swine Health and Information Center Board of DirectorsDirection and oversight of programsResearch Selection Task ForceEndemic Swine Disease Task ForceInternational Swine Disease Task ForceLifespan5 year lifetime unless it is extended by recommendation of the Center’s Board of Directors and the approval by the NPBTo address these concerns about how to better address future emerging diseases NPPC passed a wide-ranging resolution at this spring’s Pork Forum.It was a multi-part resolution – including developing a plan in the event of new economically significant swine diseases. T
34Swine Health and Information Center Scope of Work:Swine Disease Matrix projectSwine health data monitoring, management and analysis for disease trendsPriority Order:Swine Health Monitoring ProjectEmerging disease monitoring dataProduction Animal Disease Risk Assessment Program (PADRAP)Secure Pork Supply databaseTrade supportUSDA sanction of data is essential to fulfilling this functionTo address these concerns about how to better address future emerging diseases NPPC passed a wide-ranging resolution at this spring’s Pork Forum.It was a multi-part resolution – including developing a plan in the event of new economically significant swine diseases. T
35SummaryPEDV probably will not be the last emerging disease the industry faces; therefore, an emerging disease plan is essential!!As part of that plan, monitoring of global disease issues is critical and includes pre-emptive plan for key needs for disease Dx and managementCooperation and collaboration between all sectors of industry and government is a must.