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Trauma in Pregnancy James Huffman Resident Rounds – October 12, 2006 Thanks to Yael and Shawn.

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Presentation on theme: "Trauma in Pregnancy James Huffman Resident Rounds – October 12, 2006 Thanks to Yael and Shawn."— Presentation transcript:

1 Trauma in Pregnancy James Huffman Resident Rounds – October 12, 2006 Thanks to Yael and Shawn

2 Epidemiology Trauma occurs more often during the 3 rd trimester than at any other time in a woman’s life 7% of pregnancies are complicated by trauma It is the leading cause of maternal death, accounting for 46% of fatalities in pregnant women Most common causes are MVCs, falls, assults, and domestic violence plays a very significant role in this population

3 Challenges Smaller evidence base Two patients Determining fetal viability Physiologic and anatomic changes 1-3% of minor trauma results in fetal death!

4 Approach Four groups: 1. Early pregnancy – mothers not aware, vulnerable to radiation 2. Fetus not yet viable – well protected in bony pelvis, required maternal survival for development 3. Viable pregnancies (>24-26 weeks) – most challenging, two patients to consider 4. Perimortem – resuscitation +/- C-section Being pregnant does not affect maternal survival The most common causes of fetal death are maternal death and placental abruption*

5 Anatomic Changes Uterus – pelvic in T1, then pushes structures out of the way Decreased sensitivity to peritoneal injury Pelvic outlet widening Symphysis pubis and SI joint spaces increase in the 7 th month  pelvic x-rays “Supine Hypotensive Syndrome” At >20 weeks GA, the uterus can compress the IVC, decreasing preload

6 Cardiovascular Changes Some changes present like shock:  Hypotension declines in T1, stabilizes in T2, returns to normal in T3 SBP (2-4 mmHg) < DBP 5-15mmHg d/t progesterone and supine hypotensive syndrome  Increased baseline HR (usu bpm)  CVP decreases to 4 from 9mm Hg by term Do not attribute changes in BP or HR entirely to physiology – consider them harbingers of shock!

7 Cardiovascular Changes - 2 Some changes mask shock: Increased blood volume – as much as 48-58%, peaking at 32-34/52 Cardiac output increased by 40% at term (6L/min) With significant blood loss, maternal BP is preserved at the expense of the uteroplacental and splanchnic circulation  early fetal monitoring Blood loss will exceed 30% of total blood volume before hypotension is manifest

8 Respiratory Changes Pregnancy significantly reduces oxygen reserve:  20% reduction in FRC 2° to diaphragm elevation  15% increase in oxygen consumption related to the growing fetus, uterus and placenta  Progesterone stimulates the respiratory centre in the medulla, leading to hyperventilation and respiratory alkalosis with metabolic compensation (pCO2 usually ranges from 27-32)  Significance: Intubation and Chest-tube placement!

9 Gastrointestinal Changes ↓ GE sphincter tone and gastrointestinal motility ↑ acid production in stomach Increased risk of aspiration!

10 Hematologic Changes Blood volume increased more than RBC mass  dilutional “anemia” (Hg as low as 100, and Hct of 32-34%) ↑ WBC (up to ) ESR increased but CRP unchanged Increased risk of thromboembolism:  ↑ stasis (venous compression, capacity, bed rest)  ↑ coagulation factors V, VII, VIII, IX, X, XII and fibrinogen (by T3) exceeds fibrinolytic activity.

11 ECG changes The elevated diaphragm causes a leftward axis shift averaging 15° Q waves in leads III and aVF Flattening of T-waves in III and aVF

12 Mechanisms of Injury: Blunt Trauma Most common cause is MVCs; half of pregnant women are not using seatbelts correctly or at all Next are assaults (domestic violence) and falls  20% incidence of domestic violence in the pregnant population  80% of falls occur after 32 weeks GA If the mother survives, placental abruption is the most common cause of fetal mortality  Incidence in minor trauma is 2-4%; 30-50% incidence in survivors of major trauma  Sensitivity of US is <50%, clinical signs and symptoms are often also unreliable Incidence of fetal loss from minor trauma is 1.7%

13 Penetrating Trauma Maternal visceral injuries are less common during pregnancy Fetus is at high risk Fetal injury complicates 66% of gunshot wounds to the uterus Fetal mortality ranges from 40-70% in cases of penetrating trauma (stab wounds carry a lower mortality for both mother and fetus)

14 Burns In severe burns there is a dramatic increase in fetal mortality, approaching 100% for burns >50% TBSA; only 6% survival for burns >30% TBSA Risk to the fetus is maternal death, fetal death, and preterm labor (PGE 2 ) Maternal carbon monoxide levels are a poor predictor of fetal carboxyhemoglobin

15 Other Mechanisms of Injury Domestic Abuse  between 0.9% and 20.1% of pregnant women are victims of domestic violence Self-harm  Suicide was the cause of death in 13% of maternal deaths in one study (New York)

16 General Management The most common cause of fetal death is maternal death*, so efforts to assess fetal well being are second to resuscitation of the mother Fetal distress may be the earliest indication of maternal injury, so FHR should be used early as an adjunct to the secondary survey Prehospital tachycardia (HR >110), chest pain, LOC, and 3 rd trimester GA all independently correlate with the need for a trauma centre

17 Primary Survey Should be no different in the pregnant patient Airway Fetal RBC have increased affinity for O2, so oxygen can provide significant improvement in fetal saturation Breathing Consider hyperventilation due to chronic resp. alkalosis ABG for acidosis, Base Deficit (hemorrhage) and hypoxia Circulation IVC compression  need to displace uterus to the left Early crystalloid fluid resuscitation (RL vs NS) Avoid vasopressors  reduce uterine blood flow Likely little roll for tocolytics Caudal central venous access if possible

18 Primary Survey - 2 *Abdominal exam/Fetal Primary Survey Assess uterine size re:fetal viability (beware of uterine rupture) Viable fetus (22-26 weeks) – 2-3 finger breadths above uterus Uterine Rupture/Abrutio Placentae Peritoneal finding will likely be masked Initial fetal heart tones (FHT) >10 weeks Continuous Cardiotocographic monitoring (CTM) if viable fetus

19 Algorithm

20 Secondary Survey The secondary survey includes a more thorough fetal assessment, a pelvic exam and a history including pertinent prenatal information. Re-assessment of fetal viability CTM should be initiated in a viable fetus The pelvic exam includes a sterile spec exam for amniotic fluid, cervical dilation & effacement, signs pelvic trauma, vaginal bleeding (+/- cultures) but… NO PELVIC IN T3 BLEEDS! Diagnostic adjuncts (labs, imaging)

21 Intellectual Breather… Who needs a preg test?

22 Intellectual Breather… Oldest person to give birth? Adriana Iliescu  Age 66  Romania  2005

23 Intellectual Breather… Youngest person to give birth? Lina Medina  5 years, 7 months  Peru  1939

24 Laboratory “trauma labs” plus Rh status, coags, fibrinogen levels βhCG:  +’ve in serum 9d post conception  +’ve in urine 28d after last menstrual period A Kleihauer-Betke test may be considered in an Rh –’ve mother for evaluation of fetal-maternal hemmorhage Complications include Rh sensitization, fetal anemia or fetal death from exsanguination Lab only screens for FMH of >5mL, therefore all Rh –’ve mothers should receive prophylactic RhIG

25 RhIG 1 st trimester patients should receive 50mcg dose (covers 5mL bleeding); patients >12 weeks should get 300mcg dose (protects against 30mL FMH) KB test quantifies FMH – >12 weeks may have more than 30mL FMH and need a second dose of RhIG RhIG effective if given in first 72 hours after FMH

26 Diagnostic Imaging General rule: If imaging is indicated, it should be done 1 rad of exposure – no increase risk to the fetus 10 rad exposure – carries only a small increase in the number of childhood cancers 15 rads exposure - carries a 6% chance of MR, 3% chance of cancer, 15% chance of microcephaly >20 weeks, radiation is unlikely to cause fetal anomalies, particularly if the exposure is <10 rads A CT abdo pelvis exposes the fetus to 5-10 rads

27 Radiation Doses (mrad) Low dose plain film  Head, c-spine, thoracic spine, chest, extremities (<1 mrad) High dose plain film  L-spine ( )  Pelvis ( )  Hip ( )  IVP ( )  KUB ( ) CT  Head (<50)  Chest (<1000)  Upper abdomen (<3000)  Lower abdomen ( )

28 Diagnostic Imaging Adjuncts Ultrasound/FAST  Best modality for assessment of mother and fetus in setting of trauma, rapid and safe  Sensitivity of 88%, specificity of 99% for detecting abdominal injury in blunt trauma  Screens for free fluid and establishes fetal well being, GA and placental location DPL  Supra-umbilical approach, open technique  Useful in the first trimester patient with an equivocal FAST, and later in pregnancy to help differentiate intraperitoneal bleeding from a uteroplacental source

29 Algorithm

30 Fetal Evaluation - FHT Fetal heart tones can be heard by doppler beginning at weeks If FHR 160, fetal distress is likely and urgent obstetric consultation is indicated (they should hopefully be there already!) If FHR is normal, proceed to continuous CTM for at least four hours

31 Fetal Evaluation CTM has an excellent sensitivity for detecting abruption; 100% NPV for adverse outcomes if reassuring clinical exam and normal observation period  If >3 uterine contractions/hr, persistent uterine tenderness, non-reassuring fetal monitoring strip, vag bleeding, ROM, or serious maternal injury = admit for long term monitoring CTM recommended for a minimum of 4 hours for all patients >20 weeks GA with any multisystem or minor abdominal trauma Increase to 24 hours if any abnormalities

32 CTM – what are we looking for? Baseline FHR ( ) Variability – indicator of oxygenation  Beat-to-beat (CNS)  Long term (fetal activity) Periodicity  Accelerations  Decelerations

33 CTM - Decelerations Early Decelerations:  Gradual and uniform in shape  Early in contraction and quick return to baseline  Benign, vagal response to head compression Variable Decelerations:  Variable in shape, onset and duration  Usually due to cord compression  Benign unless meets the rule of 60’s: decel to 60 below baseline, >60s in duration

34 CTM - Decelerations Late Decelerations:  Uniform shape  Onset is late in contraction  Must see 3 in a row (same shape)  Due to fetal hypoxia, acidemia, maternal hypotension  Sign of uteroplacental insufficiency

35 CTM - Decelerations

36 Discharge and Disposition Mother stable/fetus stable: Should be instructed to record fetal movements for 1 week Should return to hospital if <4 FM over 1 hour or <10 FM in 12 hours Should also return if any abdominal pain, leaking fluid, vag bleeding, or >6 uterine contractions/hr

37 Algorithm

38 Discharge and Disposition Mother stable/fetus unstable: In trauma, fetal death rates are 3-9 times that of maternal death rates If a viable fetus remains in distress despite maternal optimization, c-section should be performed No survival if no fetal heart tone before emergency C-section begins If FH tones present and >26 weeks, infant survival for emergency C/S is 75% in the trauma setting

39 Algorithm

40 Discharge and Disposition Mother unstable/fetus unstable If mom’s conditions is critical, primary repair of her wounds is the best course even if fetus is in distress However, extended and exclusive attention to the mother in cardiac arrest mother may prevent recovery of a potentially viable fetus If no response to ACLS and there is a potentially viable fetus (fundal height above the umbilicus & FHT +’ve) a decision for perimortem c-section must be made

41 Algorithm

42 Perimortem Cesarean Section If performed at appropriate time, can benefit both fetus and mother (due to improvement in maternal circulation) If mother arrests and does not respond to resuscitative efforts within 4 minutes, preparation for open cardiac massage and C-section should begin 70% of children who survived perimortem C-sections were delivered in less than 5 min of onset of arrest (4 min resuscitation and prep time, 1 min delivery time)

43 Perimortem Cesarean Section Vertical midline incision from epigastrum to symphysis pubis Penetrate all abdominal layers into peritoneum Vertical midline incision in anterior aspect of uterus from fundus to bladder (avoid paired uterine vessels laterally) Extend caudally using blunt dissection (scissors), placing your hand between the uterine wall and the fetus Deliver head and shoulders, body follows spontaneously Suction, clamp and cut cord, resuscitate neonate prn

44 Questions?

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