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Bcl-2 and its Role in Cancer. Mitochondria in the Cell

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Presentation on theme: "Bcl-2 and its Role in Cancer. Mitochondria in the Cell"— Presentation transcript:

1 Bcl-2 and its Role in Cancer

2 Mitochondria in the Cell

3 Cytochrome C’s Dual Functionality Protein that carries electrons in electron transport chain between mitochondrial membranes BUT released into cytosol, triggers apoptosis Cytochrome_C.png

4 Bcl-2 family – apoptosis regulators ma_htmlcourse/page3

5 Stress signal (DNA damage, heat shock) Pro-apoptotic members activated Cytochrome c release via MOMP Cytochrome c complexes with ATP and Apaf-1 (enzyme) Caspase-9 activated, then forms apoptosome with previous complex Caspase cascade to apoptosis Apoptosis Pathway

6 Viable, but smaller Half die by 6 weeks Smaller kidneys Skeletal development Immune failure Bcl-2 Knockout Mice

7 https://encrypted- tbn3.gstatic.com/images?q=tbn:ANd9GcTkoz4iPsXeDUTi1dbV1wzIQsD8sDB7HqkRJaxih9U4 UWe9Cusd-A Non- Hodgkin Lymphoma

8 Bcl-2 Translocations Found in Cancer

9 htmlcourse/page3 Overexpression of Bcl-2 on the Outer Membrane of Mitochondria

10 Inhibiting Bcl-2

11 m4s3c_3.jpg Potential Therapeutic Undergoing Clinical Trials

12 Sources / /pdf/iep_79.pdf ngcancer/targetedtherapies/lymphoma_htmlcour se /S


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