11Mendelian Inheritance Caused by mutations in the nuclear genomeNuclear DNA is inherited from both parentsSince much of the mitochondrial DNA is encoded for by the nuclear genome, mitochondrial disease can also follow a mendeliajn pattern of inheritance.That is to say, it can be inherited from the chromosomes.
12Autosomal dominant http://www.natera.com/single-gene-testing These are caused by mutations in dominant genes, which means you only need one copy of a faulty gene to express the diseaseThe person with the faulty gene has a 50% chance of passing it on to their childrenMales and females are equally affectedEither the father or the mother can pass down the faulty gene down to the next generation
13Autosomal recessive http://www.npr.org/ In autosomal recessive disease, you need two copies of a faulty gene to be present before the disease occurs
14Sporadic disease Affected Sporadic disease arises from a new mutation that occurs in the affected person. It is not inherited from either parent.However, the patient affected by a sporadic mutation can pass the faulty gene on to their children.These de novo mutations can occur in the mitochondrial genome or in the nuclear genome.Affected