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HIV & Pregnancy Dr. med. Annette E. Haberl Universitätsklinikum Frankfurt am Main Infektionsambulanz.

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Presentation on theme: "HIV & Pregnancy Dr. med. Annette E. Haberl Universitätsklinikum Frankfurt am Main Infektionsambulanz."— Presentation transcript:

1 HIV & Pregnancy Dr. med. Annette E. Haberl Universitätsklinikum Frankfurt am Main Infektionsambulanz

2 Frankfurt HIV-Cohort Patients May May 2001 (n=2465) 1898 (77%) 567 (23%)

3 Frankfurt HIV-Cohort: Increase of Patients 19% 36%22% 24% 19%24%

4 Frankfurt HIV-Cohort: Pregnancies since January 1999 all pregnancies: 78 born children to date: 57 (1999: n=15; 2000: n=27; 2001: n=15) missed abortions: 4 interruption (medical reasons): 1 ongoing pregnancies: May 2001

5 Frankfurt HIV-Cohort: Characteristics of pregnant women 15 patients: IDU 35 patients: Pattern II 28 patients: HES Period of observation: January 1999-May 2001n= 78 patients

6 Pregnant Patients from Pattern-II- countries (n=35) Countries of origin of the children fathers 17/35 with a German husband/boyfriend HIV-test 6/17 : 1/6 HIV-positive 18/35 with a husband/boyfriend from the same mother-country HIV-test 7/18 : 1/7 HIV-positive

7 Frankfurt HIV-Cohort: Prophylaxis of vertical transmission & HAART during pregnancy high risk for transmission: 10 pts. HAART: 24 pts. prophylaxis : 23 pts Period of observation January 1999-May 2001n= 57 patients

8 Frankfurt HIV-Cohort: Prophylaxis of vertical transmission (n=23) Combivir:21patients Retrovir:2patients

9 Frankfurt HIV-Cohort: Prophylaxis of vertical transmission high risk patients (n=10) NRTI´splus NNRTI (n=9) NRTI´s (n=1)

10 Frankfurt HIV-Cohort: HAART of pregnant women (n=24) NRTI´splus PI10patients NRTI´splus NNRTI14patients

11 HIV & pregnancy: Improvement in quality German-Austrian Recommendations for the Treatment of HIV-positive Pregnant Women Resistence testing Pharmacokinetics Documentation & publication

12 Frankfurt HIV-Cohort: Management of pregnant women from Pattern-II-countries First positive HIV-test during pregnancy (all: 18/78; migrants: 12/35) Communication problems Social and/or political situation Isolation Lost-to-follow-up after delivery

13 Frankfurt HIV-Cohort: Management of pregnant IDU´s Comorbidity Lack of compliance Ongoing use of illegal drugs Social problems Lost-to-follow-up after delivery

14 Frankfurt HIV-Cohort: Management of HIV & Pregnancy Results observational period I/1999-V/2001; n=57 no case of vertical transmission of HIV 1 case of transmission of HCV (12 pregnant women coinfected with hepatitis C)

15 Management of HIV & Pregnancy Social work Medical care mother Political duty Medical care child

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