Presentation on theme: "Tobacco Cessation Interventions in Pregnancy Eric L. Johnson M.D. Physician Consultant North Dakota Tobacco Quitline/Quitnet Assistant Professor Department."— Presentation transcript:
Tobacco Cessation Interventions in Pregnancy Eric L. Johnson M.D. Physician Consultant North Dakota Tobacco Quitline/Quitnet Assistant Professor Department of Family and Community Medicine University of North Dakota School of Medicine and Health Sciences
Objectives Assess status of Tobacco Cessation Interventions for Pregnant Patients by OB/GYN providers in North Dakota Translate this data into effective practice for OB/GYN providers Understand current Tobacco Cessation Interventions for Pregnant Patients
Tobacco Cessation Interventions by OB/GYN Providers in North Dakota Study by UNDSMHS NORTHSTAR Research 7 question survey Mailed/e-mailed to 110 OB/GYN providers in North Dakota (OB/GYN, FP Physicians and Mid-levels) * 73 surveys returned (65% of total) *list compiled with assistance from North Dakota Chapter of the American College of Obstetrics and Gynecology
Do you provide care to pregnant patients in your practice?
Do you assess pregnant patients for tobacco use?
Do you offer tobacco cessation options to pregnant patients?
Which of the following cessation tools are offered in your practice?
Are any of these materials designed exclusively for pregnant women?
Do you offer counseling to pregnant patients regarding tobacco cessation?
What types of counseling do you offer pregnant patients for tobacco cessation?
Do you prescribe medications to pregnant patients for tobacco cessation?
Which medications do you prescribe to pregnant patients for tobacco cessation?
Conclusions of Study Most North Dakota OB/GYN providers are aware of Tobacco Cessation resources available to their patients who smoke Most North Dakota OB/GYN providers offer Tobacco Cessation to their pregnant patients who use tobacco Review of medication use for Tobacco Cessation in pregnant patients
Why Tobacco Cessation? Benefits in pregnancy and long term health Reduce Cardiovascular Complications Reduce Lung Disease Reduce Cancer Reduce Type 2 Diabetes Economic benefit for individual and society
Smoking in Pregnancy Smoking in pregnancy higher in North Dakota than national average: 18% vs. 11% Smokers tend to be from lower socioeconomic and educational classes WIC smoking population as high as 40%+ in North Dakota North Dakota Department of Health
Smoking in Pregnancy ~75% of pregnant smokers desire quitting ~25-30% actually quit during pregnancy ~50% resume after pregnancy Smoking Cessation is most successful prior to pregnancy Ruggiero L, et al Addict Behav. 2000 Mar-Apr;25(2):239-51 Ebert LM Fahey K Women Birth. 2007 Dec;20(4):161-8 Tong VT, et al Am J Prev Med. 2008 Oct;35(4):327-33.
Complications of Smoking in Pregnancy Fourfold increase in small for gestational age; Increased prematurity Twice the rate of spontaneous abortions Increased risk of abruptio placentae, placenta previa, premature and prolonged rupture of membranes Russell, T, et al Nicotine & Tobacco Research, Vol6, Supp 2. Apr. 2004 Gabbe: Obstetrics 4th ed 2002 George L, et al Epidemiology. 2006 Sep;17(5):500-5 Faiz AS, Ananth CV.J Matern Fetal Neonatal Med. 2003
Complications of Smoking in Pregnancy Intrauterine growth restriction Stillbirth Ectopic pregnancy Infertility Poor wound healing/surgical outcomes Russell, T, et al Nicotine & Tobacco Research, Vol6, Supp 2. Apr. 2004 Gabbe: Obstetrics 4th ed 2002 Högberg L, Cnattingius G. BJOG. 2007 Jun;114(6):699-704.
Fetal/Child Effects of Maternal Smoking in Pregnancy Sudden infant death syndrome (SIDS) and increased respiratory illnesses in children Possible Association with maternal smoking and ADHD/Behavioral Disorders Congenital Anomalies (i.e., cleft lip/palate, cardiac) Linnett KM, et al Pediatrics 2005; 116: 462-467 Malik S, et al Pediatrics 2008 Apr;121(4):e810-6 Shi M, et al Am J Hum Genet. 2007 Jan;80(1):76-90
Issues in Smoking Cessation Triggers Mood changes Withdrawal symptoms (most smokers underestimate) Weight gain Lack of support Exposure to other smokers
Smoking Cessation Interventions in Pregnancy Brief Office Counseling Smoking Cessation Class (i.e., Public Health) Third Party Payer programs Quitlines Online programs (i.e., Quitnet) Pharmacologic
Smoking Cessation Interventions in Pregnancy 5 A’s ASK about tobacco use (Tobacco as a vital sign) ADVISE to quit ASSESS willingness to make a quit attempt ASSIST those who are ready, with appropriate treatment those who are not ready, with motivational counseling ARRANGE for follow-up USPHS 2008
Pregnancy affords a great opportunity Multiple short term followup clinic visits Phone calls/e-mail/quitline/quitnet ASK every time Options every time Smoking Cessation Interventions in Pregnancy
Nicotine replacement therapy (NRT) –Gum –Patch –Spray –Inhaler –Lozenge Bupropion (Zyban, Wellbutrin) Varenicline (Chantix) All are first line non-pregnant USPHS 2008
Pharmacotherapy for Pregnant Smokers NRT- Category D. Secreted in breast milk. Crosses placenta Buproprion (Wellbutrin, Zyban)- Category B. Metabolites in breast milk. Risk of seizure (low). Increase spontaneous abortion 1 st trimester? Varenicline (Chantix)- No data (yet) Oncken CA, Kranzler HR Nic Tob Res Nov 2009
Pharmacotherapy for Pregnant Smokers USPHS 2008 more limited recommendations vs USPHS 2000 ACOG 2005: NRT for heavy smokers if other nonpharmacologic interventions fail
Nicotine Replacement Therapy in Pregnancy 6 randomized controlled trials 2000-2010 5 show possible benefit Higher birth weight in 1 trial Multimodal treatment-benefit? Oncken, C et al Obstetrics & Gynecology, 112(4), 859-867. Pollak, KI et al. American Journal ofPreventive Medicine, 33(4), 297-305. Hotham ED et al Addictive Behaviors, 31, 641-648. Hegaard HK et al Acta Obstetricia et Gynecologica Scandinavica, 82, 813-819. Kapur, B, et al Current Therapeutic Research, 62(4), 274-278. Wisborg, K, et al Obstetrics & Gynecology, 96(6), 967-971.
Pharmacotherapy for Pregnant Smokers NRT use must be risk vs benefit -heavy smoker, relapsers, other risk ? (i.e. CVD risk factors) -if NRT used, intermittent (gum, lozenge) -higher birth weight? Buproprion? 1 study shows benefit * Varenciline- not recommended presently *Chan B et al J Add Dis (24) 19-23 2005
Pharmacotherapy for Pregnant Smokers Smoking, Nicotine, and Pregnancy Trial Currently underway (UK study) Projected publication is 2013
In Office Counseling Brief No additional cost Slightly increases quit rates in non- pregnant adults
Classes Maybe difficult to access in rural areas (variable) Availability Public Health, American Lung Association, Employers Sometimes cost Effective
Quitlines Free Widely available Effective ND Quitline ~30% 13 month quitrate in general population ND Quitline Free NRT for qualifying MN Quitplan
Online Services Third party payers ND Quitnet: Premium content to ND residents, launched Feb 2010 ND Quitnet Free NRT
nd.quitnet.com Free to all North Dakota Residents Free NRT for qualifying 1-800-784-8669
Quitlines Other surrounding states have quitlines 1-800-QUITNOW is universal in U.S. Third Party Payers, Health Care Systems
Nicotine Addiction Smokers are addicts…………….. Nicotine is a highly addictive substance…. Successful treatment is based on addiction treatment principles…… Behavioral/Cognitive/Motivational Interviewing Pharmacotherapy (when appropriate)
Challenges for Long-Term Tobacco Cessation Pregnant smokers tend to not be “committed quitters” Limitations of medication prescribing for pregnant/lactating smokers Smoking is nicotine addiction, not just a bad habit
Summary Smoking is problematic in pregnancy Long Term Health issues- mother and baby Nonpharmacologic resources first line for most pregnant smokers Possible limited role for NRT in select patients
Review Articles Crawford J, et al Smoking Cessation in Pregnancy: Why, How, and What Next Clinical Obstetrics &Gynecology June 2008 Oncken CA, Kranzler HR What do we know about the role of pharmacotherapy for smoking cessation before or during pregnancy Nicotine Tob Res. Nov 2009
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Acknowledgements Dr. Charles Christianson, NORTHSTAR, UNDSMHS Jessica Behm, NORTHSTAR, UNDSMHS North Dakota Chapter of the American College of Obstetrics and Gynecology North Dakota Department of Health, Division of Tobacco Prevention and Control