Presentation on theme: "Uterine & Ovarian Cancer"— Presentation transcript:
1Uterine & Ovarian Cancer Uterine CancerAtypical HyperplasiaFrom hyperplasia to endometrial cancerPrevalence & IncidenceCausesRisk factorsDetectionTreatmentOvarian CancerSymptoms
2I. Endometrial Cancer – Uterine Cancer Endometrial cancer usually begins in the lining of the uterus (endometrium). It is sometimes called uterine cancer.Vast majority are adenocarcinomas – commonly detected during perimenopausebut there are other cells in the uterus that can become cancerous — such as muscle or myometrial cells.
3A. Atypical Hyperplasia = abnormal tissue growth simple hyperplasia without atypia = a proliferation of cells, but the basic structure of the endometrium is relatively unchangedcomplex hyperplasia without atypia = individual cells may be enlarged, but the internal makeup of the cells is considered to be normal. However, the cells have proliferated to the point where the normal structure of the endometrium is interfered with. Hyperplasia with atypia = precancerous, Approximately 25-30% of hyperplasia in this category will progress to endometrial cancer.
6C. Prevalence & Incidence ACS predicts that 41,200 American women will receive a diagnosis of “uterine” endometrial cancer this year, making it the fourth most common cancer found in women — after breast cancer, lung cancer and colon cancer.Although this cancer is 40% more common in white women, black women are nearly twice as likely to die from it.
8E. Risk Factorsobesity -- particularly being more than 50 pounds overweight (fat tissue can convert other hormones in the body into estrogens)type 2 diabetes - some data suggest that women who have diabetes, whether they're obese or not, are at greater risk of endometrial cancerearly menstruation (periods starting before age 12) & late menopause (after age 52)nulliparity (never having given birth) or a history of infertility (an inability to become pregnant)ovarian diseases, such as polycystic ovaries, that may cause a woman to have higher than normal estrogen levels and lower than normal progesterone levelsestrogen-only replacement therapy (ERT)
9Additional potential contributors: Family history – possible genetic linkHereditary nonpolyposis colorectal cancer (HNPCC). Inherited disease caused by an abnormality in a gene important for DNA repair. Women with HNPCC also have a significantly higher risk of endometrial cancer.Personal history of breast cancer or ovarian cancer –Stress
10F. Symptoms of endometrial cancer Abnormal uterine bleedingHeavy bleeding during or between periods, and bleeding after menopause.More frequent vaginal bleeding or spotting during the years leading up to menopause.In some cases, the discharge associated with endometrial cancer is pink, or white rather than red.Difficult or painful urination or pain during intercourse.In later stages of the disease, women may feel pelvic pain and experience unexplained weight loss.
12Hysteroscope allows doctors to do a direct visual examination of the endometrium. The lighted tip of the instrument is inserted through the vagina and cervix into the uterine cavity.There the doctor can inspect any abnormal tissues and, using a tiny electrified loop, can even take samples for later lab analysis.
13Additional Diagnostic Tests CA-125 blood test –Cystoscopy (to check for cancer in the bladder)Proctoscopy (to check for cancer in the rectum)Other imaging tests such as computed tomography (CT) scanning and magnetic resonance imaging (MRI), chest x-ray, or an intravenous pyelogram (x-rays of the pelvic region taken after the injection of a contrasting agent)
15H. TreatmentTreatment of hyperplasia without atypia
16Treatment of hyperplasia with atypia The suggested treatment for atypical complex hyperplasia is usually hysterectomyIn pre-menopausal women who wish to conceive, high dose progestin treatment with close monitoring is an accepted alternative to hysterectomyCancer - Options for treatment depend chiefly on the stage of the disease (the size of the cancer, the depth of invasion, and whether the cancer has spread to other parts of the body).Radiation therapy and/or chemotherapy may be necessary
17Stages for endometrial cancer are: Stage I. Cancer is limited to the uterus.Stage II. Cancer involves the uterus and cervix.Stage III. Cancer has spread out of the uterus but is restricted to the pelvic region.Stage IV. Cancer has spread to the bladder, bowel, or other distant locations.
18Survival rates5 year survival rates for endometrial cancer by stage are:
20II. Ovarian CancerFor most pre-menopausal women, a growth on the ovary is benign (90%) – for post-menopausal women there is a 70% chance of it being benignTumor growth that begins in the egg-producing cells (germ cell tumors) –Tumor growth that begins on the surface of the ovary (epithelial cell tumors)
21epithelial cell tumors Tumors of low malignant potential (LMP tumors) do not appear to be clearly cancerous.AKA borderline tumors.affect women at a younger age than other ovarian cancers.grow slowly and are much less serious than most ovarian cancers.Epithelial ovarian cancers: Nearly 9 out of 10 ovarian cancers are of this type.Grade 1 means the cells look more normalGrade 2 somewhat abnormalGrade 3 look highly abnormal.
22Prevalence & Incidence An estimated 20,180 women will be diagnosed with ovarian cancer in the US in 2006.This year, about 15,310 women will die of the disease –
23A. Risk FactorsContinuous egg production (never pregnant, never used birth control, or first birth after age 30)Early menstruation (periods starting before age 12) or late menopause (after age 52)ObesityDiet – saturated fat increases risk, high fiber lowers riskFertility drugs – studies indicate prolonged use clomiphene citrate, especially without achieving pregnancy, may increase the risk for developing LMP tumors.Estrogen replacement therapy? - A recent study suggested that using ERT increases the risk of developing ovarian cancer, and that the risk increases with continued use.Genetics? the risk is higher among women whose close blood relatives (mother, sister, daughter) have (or had) this disease.<10% of women found to have ovarian cancer have inherited the diseaseBRCA1 and BRCA2 are implicated in ovarian cancer tooFamily history breast cancer
24B. Symptoms of ovarian cancer Swelling of the stomach (abdomen) from a buildup of fluidUnusual vaginal bleedingPelvic pressure, crampsUnexplained changes in bowel habits, including diarrhea or constipationChanges in bladder habits, including a frequent need to urinateLoss of appetiteBack or leg painProblems such as persistent gas, bloating, long-term stomach pain, or indigestion
26D. TreatmentHow much and what type of surgery depends on how far the cancer has spread, general health, and whether or not she still hopes to have childrenFor LMP tumors:Unilateral Oophorectomy -Bilateral oophorectomy –Uni/bilateral salpingectomy –Debulking – shrinking of the tumorRadical hysterectomy + removal of omentum (fat pad that surrounds the intestines)Radiation and/or chemotherapy
27Stages of ovarian cancer Stage I: The cancer is contained within the ovary (or ovaries).Stage II: Cancer is in one or both ovaries and has spread to other organs in the pelvis, such as the bladder, rectum, or uterus.Stage III: The cancer is in one or both of the ovaries and has spread to the lining of the abdomen or to the lymph nodes.Stage IV: This is the most advanced stage. The cancer has spread from one (or both) ovaries to distant organs, such as the liver or lungs.