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DISCOVERY OF THE STRUCTURE OF DNA Hank Oliver and Chelsea Peacock.

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Presentation on theme: "DISCOVERY OF THE STRUCTURE OF DNA Hank Oliver and Chelsea Peacock."— Presentation transcript:

1 DISCOVERY OF THE STRUCTURE OF DNA Hank Oliver and Chelsea Peacock

2 Frederick Griffith  Discovered the process called transformation  Found a transforming agent that survived heat and change a bacteria to virulent

3 Oswald Avery and Colleagues  Proved DNA was the transforming compound  Used protein-destroying enzymes to destroy proteins, RNA-destroying enzymes to destroy RNA, and DNA- destroying enzymes to destroy DNA.  Transformation was stopped when DNA-destroying enzymes were used.

4 Alfred Hershey & Martha Chase  Performed experiment with T2 bacteriophage  Using radiolabeled proteins and DNA and followed them.  Experiment proved DNA was transforming agent

5 Rosalind Franklin & Raymond Gosling  Worked together to produce the first X-ray diffraction pictures of DNA  Their picture of DNA was stolen by Watson & Crick to determine the structure of DNA

6 Erwin Chargaff  The amount of cytosine equals the amount of guanine and the amount of adenine equals the amount of thymine.  Adenine ALWAYS pairs with Thymine; Guanine ALWAYS pairs with Cytosine – Chargaff’s Rule

7 Maurice Wilkins  Studied the orientation of purines and pyrimidines in DNA  Developed well-defined X-ray diffraction pictures of DNA which led to Watson and Crick’s DNA model

8 James Watson & Francis Crick  First to determine structure of DNA  Double helix  Chargaff’s Rule  Made of sugar-phosphate backbone with bases hydrogen bonded together holding two strands together

9 References Griffith Experiment Avery Experiment Hershey & Chase Experiment Rosalind Franklin’s X-ray Picture Rosalind Franklin Picture Raymond Gosling Picture Image for Chargaff’s Rule Chargaff Picture

10 References Maurice Wilkins Picture Watson and Crick Picture wilkins-franklin.aspx DNA Structure


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