LYMPHOPOEISIS THYMUS LYMPH PPT SC CFU S CFU L NK PRO T PRO B CD 3, 4, 8 TCRBCR BONE MARROW TdTADA Gene Reshuffling CD 8CD 4 Lack = X-linked agammaglobulinemia Lack = SCID GVHD Lack: Di George’s Syndrome
B-cell Maturation Humoral Immunity Lymph Tissues Resp. TractGI Tract Payer's Patches Lack of IgA: Selective IgA Deficiency PRO BPRE BImmature B Naïve B B Cell Memory Cell Plasma Cell Mainly IgA, IgG Chr 14 Reshuffling Heavy Chain Mu Chr 2-22 Reshuffling Light Chain Y Y Y YY Y Y Y Y Y Switch Class IgM IgG Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Antigen CD-10 CALLAALL Pre-B CD-21 EBV Y Y Rabbit Ab To count B cells Multiple Myeloma if found in blood Adult ALL, CLL Y Y Y Transplant Hyperacute reaction Encapsulated Bacteria Strep pneumonia Diphtheria Or Tetanus Toxin Thyroid Loses TdT Tumor Y B-cells
T-cell Maturation Cell Mediated Immunity THYMUS THTX LYMPH THTX TH TH 1 TH 2 TDH TX T Reg B BLOOD CD 4 CD 8 CD 4 MAC HIV Mast BM Loses TdT IL 2 IFN MHC-I MHC-II Endogenous: I’m infected, kill me! Exogenous: I’ve seen this bug, make Abs! IL 1 and cytokines IL 4, 5, 6, 10, 13 “Make Abs to this Ag” Transplant Delayed Rejection Anergy Test And contact dermatitis Thyroid “Remember this Ag” TB or virus Bacteria IL and cytokines Y Histamine release IgE
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