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Dean’s Workshop on Biomedical Engineering Biomedical Engineering at Yale: Collaborations and Translational Partnerships W. Mark Saltzman.

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Presentation on theme: "Dean’s Workshop on Biomedical Engineering Biomedical Engineering at Yale: Collaborations and Translational Partnerships W. Mark Saltzman."— Presentation transcript:

1 Dean’s Workshop on Biomedical Engineering Biomedical Engineering at Yale: Collaborations and Translational Partnerships W. Mark Saltzman

2 Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

3 Prior to 1996: Separate faculty research activity : Whitaker Foundation Special Opportunity Award 1996: Program in BME formed Groundwork 1999: First full class of B.S. BME graduates : Provost/ Dean of Medicine task force on BME; President Levin allocates 6 new BME faculty positions 2000: PhD Specialization in BME approved by Graduate School Foundation : Mark Saltzman and Erin Lavik hired to develop biomolecular engineering effort 2002: Bioimaging faculty secure $7M Image-Guided Neurosurgery Grant (first out of new NIH- NIBIB institute) 2003: Department of BME officially begins 2004: Richard Carson and Michael Levene hired to lead molecular imaging effort 2005: Tarek Fahmy hired to bridge drug delivery/molecular imaging Growth

4 Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

5 Biomedical Engineering at Yale: Research and Educational Strengths Biomechanics Biomolecular engineering Bioimaging

6 Richard Carson, PET imaging and modeling Todd Constable, MR imaging James Duncan, Image analysis/processing Fahmeed Hyder, MR spectroscopy Michael Levene, Biophotonics/optical microscopy Douglas Rothman, MR spectroscopy Lawrence Staib, Image analysis/processing Steven Zucker, Computer vision Jacek Cholewicki, Spine biomechanics Tarek Fahmy, Targeted drug delivery Erin Lavik, Tissue engineering Mark Saltzman, Drug delivery/tissue engineering

7 Hemant Tagare, Diagnostic Radiology Xenios Papademetris, Diagnostic Radiology Robin deGraaf, Diagnostic Radiology Steven Segal, Physiology/Pierce Themis Kyriakides, Pathology Fred Sigworth, Physiology Mark Laubach, Neurobiology/Pierce Laura Niklason, Anesthesiology Francesco d’Errico, Diagnostic Radiology

8 Biomedical Engineering at Yale: Research and Educational Strengths Biomechanics Biomolecular engineering Bioimaging e.g. Molecular imaging e.g. Functional tissue engineering e.g. In vivo tissue function

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10 Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

11 System/Disease-Oriented Clusters Technology-Oriented Clusters Neuroengineering RC, TC, JD, FH, EL, ML, DR, MS, LS, SZ Biomaterials/Biomechanics JC, EL, MS, TF KEY Person: Paul van Tassel Vascular Engineering JD, TF, EL, MS KEY Person: Jordan Pober/VBT Bioimaging RC, TC, JD, FH, ML, DR, LS, SZ KEY Person: Jim Duncan Cancer Diagnostics/Therapeutics JD, MS, TF Biomolecular Engineering: Drug Delivery RC, ML, EL, MS, TF Immunotherapy MS, TF Biomolecular Engineering: Tissue Engineering EL, MS KEY Person: Themis Kyriakides

12 Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

13 #1 Imaging is central to Biomedical Engineering research

14 Biomedical Imaging at Yale fMRI MRS

15 Left hand (red/yellow) & right hand (blue) motor cortex activation fMRI MRS Image-guided neurosurgery for epilepsy Jim Duncan, Dennis Spencer et al.

16 Multiphoton in situ histology, Michael Levene Liver Lung Breast Ovary

17 Francesco d’Errico, Dept Diagnostic Radiology Microemulsions for ultrasound-controlled drug release Concept of image-guided drug release with ultrasound sensitive microemulsions Perflurocarbon droplets with oil inclusions containing a water-insoluble drug Doppler imaging of rabbit kidney whereby the vaporization of droplets in the renal artery reduces the blood flow The blood flow is gradually restored when bubbles dissolve in the blood-stream

18 #2 Biomolecular Engineering provides new opportunities for basic and translational research

19 Nanoparticles for Controlled Release of Curcumin Margaret Cartiera, Mark Saltzman, Marie Egan, Michael Caplan

20 Nanoparticles: particles as small as a virus, but engineered from safe synthetic polymers and loaded with high concentrations of drugs

21 Microengineered Scaffolds to Guide Cell Development to Tissues

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23 #3 Collaboration and translation

24 One biomedical engineer’s experience at Yale Neurobiology/Neurosurgery Rick Matthews, Joe Piepmaier Convection-enhanced delivery of nanoparticles Surgery Christopher Breuer Tissue engineering of large vessels Cancer Center/Dermatology Rick Edelson, Doug Hanlon Diagnostic Radiology Todd Constable, Francesco d’Errico Vascular Biology & Transplantation Jordan Pober, Themis Kyriakides Medicine/ Gastroenterology Chuhan Chung Physiology/Pediatrics Marie Egan, Michael Caplan Therapeutic Radiology Sarah Rockwell Obstetrics and Gynecology Hugh Taylor, Gil Mor Laboratory Medicine Diane Krause Ophthalmology Colin Barnstable Comparative Medicine Martha Harding, Janet Brandsma Genetics Dan DiMaio Epidemiology and Public Health Diane McMahon-Pratt

25 Opening Remarks Carolyn W. Slayman, Ph.D. Deputy Dean for Academic and Scientific Affairs 1:30-2:00 PM BIOMEDICAL ENGINEERING AT YALE: COLLABORATIONS AND TRANSLATIONAL PARTNERSHIPS W. Mark Saltzman, Ph.D. Goizueta Foundation Professor of Chemical and Biomedical Engineering and of Cellular and Molecular Physiology 2:00-2:30 PM TOWARDS THE CONSTRUCTION OF NEW GENERATION VACCINE SYSTEMS BASED ON BIOLOGICAL- DRIVEN DESIGNS Tarek Fahmy, Ph.D. Assistant Professor of Biomedical Engineering Ira S. Mellman, Ph.D. Sterling Professor of Cell Biology and Professor of Immunobiology 2:30-3:00 PM BRINGING MULTIPHOTON MICROSCOPY TO THE CLINIC: ASSESSMENT OF WOUND HEALING WITH ARTIFICIAL SKIN GRAFTS AND OTHER APPLICATIONS Michael J. Levene, Ph.D. Assistant Professor of Biomedical Engineering Jordan S. Pober, M.D., Ph.D. Professor of Pathology, Immunobiology and Dermatology 3:00-3:30 PM ARCHITECTURAL HYDROGELS: SCAFFOLDS FOR VASCULAR AND NEURAL PROGENITOR CELL CONSTRUCTS FOR THE NERVOUS SYSTEM Erin Lavik, Sc.D. Assistant Professor of Biomedical Engineering Joseph A. Madri, M.D., Ph.D. Professor of Pathology and of Molecular, Cellular and Developmental Biology

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