Presentation on theme: "Overview of Private Funder Approaches: The Health Research Alliance"— Presentation transcript:
1 Overview of Private Funder Approaches: The Health Research Alliance Kate AhlportExecutive Director, HRAScientific Management Review Board MeetingOctober 24, 2013
2 HRA Member Organizations AACR Foundation for the Prevention and Cure of CancerAlzheimer’s AssociationAlzheimer’s Drug Discovery FoundationAmerican Brain Tumor AssociationAmerican Cancer SocietyAmerican Diabetes AssociationAmerican Federation for Aging ResearchAmerican Heart AssociationArthritis FoundationAutism SpeaksAvon Foundation for WomenThe Breast Cancer Research FoundationBurroughs Wellcome FundCancer Research Institute, Inc.Children’s Tumor FoundationConquer Cancer Foundation of ASCOCURE | Citizens United for Research in EpilepsyDamon Runyon Cancer Research FoundationThe Donaghue FoundationDoris Duke Charitable FoundationThe Ellison Medical FoundationThe Flinn FoundationFondation LeducqFoundation Fighting Blindness, Inc.The Gerber FoundationHeart Rhythm SocietyThe Leona M. & Harry B. Helmsley Charitable TrustHoward Hughes Medical InstituteHydrocephalus AssociationIacocca Family FoundationJDRFW. M. Keck FoundationThe Klarman Family FoundationSusan G. Komen for the CureLeukemia & Lymphoma SocietyLUNGevity FoundationLupus Foundation of AmericaLymphoma Research FoundationMarch of Dimes FoundationThe Medical Foundation, a division of Health Resources in ActionMelanoma Research AllianceMPN Research FoundationMt. Sinai Health Care FoundationMultiple Myeloma Research FoundationNew York Stem Cell FoundationPancreatic Cancer Action NetworkParent Project Muscular DystrophyParkinson’s Disease FoundationPatient-Centered Outcomes Research Institute (PCORI)The Pew Biomedical ProgramsPhysicians’ Services Incorporated FoundationRheumatology Research FoundationRita Allen FoundationSimons FoundationSamuel Waxman Cancer Research FoundationMembership as of October, 20132
3 HRA Mission StatementHRA member organizations work together to maximize the impact of investment in biomedical research and training to improve human health.
4 Strategies by which HRA achieves its mission: The Health Research Alliance brings together not-for-profit, non-governmental funders of biomedical research and training committed to supporting and enhancing the continuum of biomedical research and training to:Foster open communication and collaboration among members.Provide comprehensive data and analysis about the funding of biomedical research and training by HRA members.Identify gaps in funding and facilitate innovative grantmaking.Address issues key to accelerating research discovery and its translation.
5 Diversity of HRA Membership Large voluntary health organizations:American Cancer SocietyAmerican Diabetes AssociationAmerican Heart AssociationPrivate foundations:Burroughs Wellcome FundDoris Duke Charitable FoundationSimons FoundationDisease-specific public charities:Foundation Fighting BlindnessMelanoma Research AllianceMultiple Myeloma Research Foundation
6 SMRB questions for funders: How does your organization set goals?How does your organization assess whether it is meeting its goals?How does your organization communicate the results of assessments to stakeholders and the public?
7 Challenges recognized by the HRA membership: Length of the “translation lag:”Of 101 promising claims in major basic science journals of new discoveries with clear clinical potential, only 5 had resulted in interventions with licensed clinical use 10 years laterIoannidis D et al (2008). “Life Cycle of Translational Research for Medical Interventions,” SCIENCE. 321,Difficulty of attributing success to one specific award/funding stream
8 Challenges recognized by the HRA membership: No ideal comparison group for awardees:Unsuccessful applicants to same award programMatched applicants or awardees from another organizationDifficulty disentangling the effects of selection bias – what accounts for differences in outcomes:The difference in the awardee group (those selected are in fact different from those not selected), ORThe award itself
9 Traditional approach for career development awards: Comparison group: highly-ranked but unsuccessful applicants (same funder)Intermediate/proxy outcome measures:Scientific productivity (publications & citations)Research support (external funding received)Current faculty position (institutional prestige, tenure status)Mavis B and Katz M (2003). “Evaluation of a Program Supporting Scholarly Productivity for New Investigators.” Academic Medicine. 78(7),
10 Traditional approach for career development awards – other examples: Leukemia & Lymphoma SocietyLichtman MA and Oakes D. (2001). The productivity and impact of the Leukemia & Lymphoma Society Scholar Program: the apparent positive effect of peer review. Blood Cells Mol Dis. 27(6):Burroughs Wellcome FundPion G and Ionescu-Pioggia M. (2003). Bridging postdoctoral training and a faculty position: Initial outcomes of the Burroughs Wellcome Fund Career Awards in the Biomedical Sciences. Academic Medicine. 78(2),Pion G and Cordray DS. (2008). The Burroughs Wellcome Career Award in the Biomedical Sciences: Challenges to and Prospects for Estimating the Causal Effects of Career Development Programs. Eval Health Prof. 31,Doris Duke Charitable FoundationEscobar-Alvarez S and Myers E. (2013). The Doris Duke Clinical Scientist Development Award: Implications for Early-Career Physician Scientists. Academic Medicine. 88(11), 1-7.
11 Project Inputs/ Resources DRAFT Career Development Award Logic ModelProject Inputs/ ResourcesStrategiesShort-Term OutcomesMid-TermOutcomesLong Term OutcomesImpactApplication / Nomination processTA from fdn staffInterviewsPeer review processFunded ApplicantsFoundation fundingOther sources of fundingInstitutional commitment (laboratory space and dedicated research time for applicant)Institutional support for clinical research (from informal to formal)[Measures: protected time, tenure policy, recruiting, core support, assistance]Expanded poolof senior-levelphysicianscientists (orclinicalinvestigators)conductinghuman subjectrelated researchresearchIncreased capacity to conduct researchIncreased pursuit of risky or nontraditional research ideasIncreased quantity and quality of research activitiesImprovedcommunicationand innovationamong seniorphysicianscientistsStrongerresearchWhat we fund:Support salary & fringe of applicantProvide research project support ( travel, supplies, equipment, publication, meetings, etc.)Cover medical school debtSupport mentor sal.How we fund:FlexibilityPortabilityBank-abilityAllocation & ExpenditureMatching fundAmount of fundingLength of timeIncreased opportunitiesLeverage to garner more resourcesStatus change & recognitionAwareness of “broader universe”Beginning relationship with colleaguesApplicant’s academic recordAdvanced degrees (PhDs, MDs)Accreditation credentialsQuality of applicant’s previous researchApplicant has less than 4-5 years of postdoctoral research trainingApplicant has not yet received a NIH-type RO1 grantInternal career advancementEstablish independent research programObtain (leverage)additional research funding.Promote to tenure positionsIncreased collaboration with clinicians & scientistsWork in private industryCareer longevityImprovedclinicalpracticecapacityof physicians /systems todiagnose andtreatIncreased individual research productivity (conferences, publications.)Increased field-level research productivityQuality of the research plan (innovative, nontraditional, the “cool” factor.)Career Advancement (promote to tenure positions, work in private industry)External career advancementBecome active in professional activity, such as serving as journal reviewers, editors, study sections.Become mentorsAssumes field leadershipConducting researchWorking with a mentor or senior researcherReceiving career development trainingReceiving TA in evaluating start-up (salary) packagesGetting mentoring trainingConveningNew therapeuticsNew scientific discoveriesNew diagnosisNew preventive strategiesImprovedhealth oftargetpopulationMentor’s stature as investigator (publication and funding history)Experience in mentoring junior researchersCurrent funding available to support applicant’s research projectImproved understanding of how to be a mentorImproved mentoring skillsUnfunded Applicants:Sharpen/improve upon their ideasIncreased understanding of high quality researchImproved Interview skillsIncreased understanding of the importance of mentorshipImproved applicationPrepared by TCC Group for Health Research Alliance
12 “Evolved” ConsensusAccept that we will never be able to disentangle whether success is due to:Picking the best candidates ORCharacteristics of the award itselfAccept that we will never be able to attribute success to a specific funder/funding stream with full certaintyMonitor/track awardees to insure they are doing what they promised to doDecide on acceptable proxy measures for outcome and impact