Presentation on theme: "They Don’t Just Make a Man"— Presentation transcript:
1 They Don’t Just Make a Man Androgens:They Don’t Just Make a ManOut of You !Aritro Sen Ph.D.University of Rochester School of Medicine & DentistryDepartment of MedicineDivision of Endocrinology & Metabolism
22 GC-ARKO Mice Have a Normal Follicle Distribution at 4-5 Weeks % of follicles
23 GC-ARKO Mice Have Decreased Follicle Progression and Increased Follicle Atresia with Age AFAGC AR +/-GC AR -/-*% of follicles***
24 Results in Slow Follicular Growth Rate Knockout of ARs in GCsResults in Slow Follicular Growth Ratediameter (μm)Follicle*GC AR -/-GC AR +/+Sen et.al., Mol Endo 2010
25 The AR is Required for Follicle Progression from Pre-Antral to Antral Stage
26 Ovaries from GC-ARKO Mice Have High Rate of ApoptosisCleavedCaspase 3]-/-+/-Granulosa cellsActinTUNNEL assay-detects DNA fragmentation that resultsfrom apoptosisSen et.al., Mol Endo 2010Supplemental Fig 1
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