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اعمال طحال اعمال طحال 1-Filtration 2-Immunologic 3-Reservoir 4-hematopoietic Dr.Azarm.

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Presentation on theme: "اعمال طحال اعمال طحال 1-Filtration 2-Immunologic 3-Reservoir 4-hematopoietic Dr.Azarm."— Presentation transcript:

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3 اعمال طحال اعمال طحال 1-Filtration 2-Immunologic 3-Reservoir 4-hematopoietic Dr.Azarm

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5 The presence of HowellJolly bodies in the peripheral blood indicates that the patient has had a splenectomy or has a process that has rendered the spleen nonfunctional

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7 The white pulp of the spleen contains macrophages, B lymphocytes, and T lymphocytes, participates in the recognition of microorganisms and foreign proteins, and is involved in the primary immune response

8 Cellular and humoral immiunity Cellular and humoral immiunity Removal of senescent red blod cells,bacteria and other particulates from the circulation Removal of senescent red blod cells,bacteria and other particulates from the circulation One third of circulating platelets are sequestered in the spleen One third of circulating platelets are sequestered in the spleen The spleen may become the site of extramedullary hematopoisis,abnormally The spleen may become the site of extramedullary hematopoisis,abnormally

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11 Physical examination(the most important) X-ray Nuclear medicine CT scan MRI

12 The splenic red pulp occupies more than half the volume of the spleen and is the site where senescent red cells are identified and destroyed and red blood cell inclusions are removed by a process known as pitting

13 It’s in posterior portion of the left upper quadrant of peritoneal cavity. It’s in posterior portion of the left upper quadrant of peritoneal cavity. It’s below the diaphragm and adjacent to the 9 th to the 11 th ribs,stomach,colon,left kidney and tail of pancreas. It’s below the diaphragm and adjacent to the 9 th to the 11 th ribs,stomach,colon,left kidney and tail of pancreas. It weighs 80 to 200 gr in males and 70 to 180 gr in females. It weighs 80 to 200 gr in males and 70 to 180 gr in females.  It is not usually palpable,except in children,adolescents and some adults especially those of asthenic build.

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15 These patients are more susceptible to bacterial sepsis,especially with encapsulated organisms.

16 Without spleen, different abnormal red cells will be present in blood circulation:  senescent red cells  red cells with nuclear remnants(Howell-jolly bodies)  insoluble globin precipitates(Heinz bodies)

17 Sepsis with encapsulated organisms,esp in children Mild degrees of thrombocytosis and leukocytosis Howell-jolly bodies in circulating red cells,along with increased number of target cells ans misshapen red cells. Increased number of erythrocyte and Heinz bodies.

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19 It is caused by splenic implants which may result from the spillage of cells from the splenic pulp following injury or splenectomy. It is caused by splenic implants which may result from the spillage of cells from the splenic pulp following injury or splenectomy.

20 . It can be located in peritoneal cavity and even in pleural or pericardial cavities. These are normal splenic tissues and can be diagnosed via tissue biopsy techniques

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22 The spleen is the larg est lymphatic organ in the body and is sometim es approached clinic ally as though it wer e a very large lymph node.

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