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Eka Pramyrtha Hestianah 08123545890. LYMPHATIC SISTEM Consist of :  LYMPH VESSEL  LYMPHATIC ORGAN : 1.LYMPH NODE 2.SPLEEN 3.THYMUS 4.TONSILLA.

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Presentation on theme: "Eka Pramyrtha Hestianah 08123545890. LYMPHATIC SISTEM Consist of :  LYMPH VESSEL  LYMPHATIC ORGAN : 1.LYMPH NODE 2.SPLEEN 3.THYMUS 4.TONSILLA."— Presentation transcript:

1 Eka Pramyrtha Hestianah

2 LYMPHATIC SISTEM Consist of :  LYMPH VESSEL  LYMPHATIC ORGAN : 1.LYMPH NODE 2.SPLEEN 3.THYMUS 4.TONSILLA

3 LYMPH VESSELS CAPILLARY  Same structure as blood vessel capillary  The deferences : wider lumen more profundus location dead end MEDIUM LYMPH VESSELS  if the diameter > 0.2 mm, the wall can be divided into 3 layers such as unclear vein layers  Always have a pair valves

4 LARGE LYMPH VESSELS Similar structure with large vein The deferences:  Developing muscle in tunica media is more dominant  The share of the wall layers is unclear Ex : ductus lymphaticus dexter

5 LYMPHATIC TISSUE consists of two components Stroma  Frame work  The sponge is like frame work  Consists of reticuler fibers and reticullum cells  Special staint: Ag Impregnasi; PAS Free cells  Fulfilling plait eyes  They are free macrophage, small-medium-large lymphocyte and plasma cells

6 The comparison of free cells and stroma is not the same  classified into 1.Loose lymphatic tissue Fulfilling sinuses and space among nodulus Loose reticuler fibers plait, therefore the plait eyes are wide and free cells filling plait eyes are little 2.Dense lymphatic tissue Dense reticuler fibers plait, therefore plait eyes are small and free cells are denser

7 Form of dense lymphatic tissue is divided into two In the form of cord  In the medulla lymph node, in the form of medullary cord In the form of lymphoid nodule (circle)  Called lymphoid nodule  At cortex lymph node, white pulp (lien), lamina propria digestive organ and respiration, tonsilla, Peyer’s patches (illium and appendix)

8 LOOSE AND DENSE LYMPHATIC TISSUE 1 1.Nodulus limfaticus (dense lymphoid tissue) Medullary cord (dense lymphoid tissue) 3. Medullaris sinus (loose lymphoid tissue

9 LYMPHOID NODULE (Nodulus Limfaticus) 1 2  DENSE LYMPHOID TISSUE FORMED OVOID (CIRCLE) CLEARLY LIMIT * Consist of : 1.Primary nodule (folicle I) The edge of nodule Consist of small lymphocyte It looks dark at sediaan 2. Germinal center (folicle II) The center part of nodule Painted paler, because its consist of large cells None at normal thymus Appear as the reaction to infection

10 RETICULLUM CELLS From mesenchyme, except at thymus that`s from endoderm. Connected with reticuler fiber Form of cells is stellate Nucleus ovoid, open faced Characteristic: Phagocyte like fixed macrophage as a buffer similar like fibroblast cells

11 LYMPH NODE The shape is like kidney Found along the way of lymph vessels Has a concave part (HILLUS), circulation place of blood vessels and nerve and the exit of lymph vessels Covered by capsule of connective tissue Divided to medulla and cortex

12 LYMPH NODE

13 LYMPH NODE FRAME Consist of collagen and reticuler frame COLLAGEN FRAME  Consist of collagen fibers  Forming capsule  Become thicker at hillus area  Forming trabeculae entering cortex in the form of partition RETICULER FRAME  Consist of reticuler fibers and reticulum cells  Forming plaits with different density so that formed dense lymphoid tissue (folicle I+II and medullary cord) and loose lymphoid tissue (inside subcapsularis sinus,- trabecularis, and medularis)

14 CORTEX OF LYMPH NODE Outer part of tissue except hillus Consist of Dense lymphoid tissue in the form of nodule, primer folicle and germinal center Loose lymphoid tissue, filling subcapsularis sinus and trabecularis sinus (perifolicularis)

15 MEDULLA OF LYMPH NODE Inner part of tissue Consist of Dense lymphoid tissue, in the form of plaques called medullary cord Loose lymphoid tissue, filling medullaris sinus The advance of subcapsularis and trabecularis sinus

16 Through Vasa afferent at upper convex Subcapsularis Sinus Trabekularis Sinus Medullaris Sinus Finally exit through Vasa efferent at hillus area Liquid lymph node circulation

17 Function To form lymphocyte To filter liquid lymph node To form antibody

18 The histology structure sketchof lymph node

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20  DEFINITION :  Accumulation of lymphoid tissue (primary nodule and germinal center) has capsule covered by epithel tissue  There are 3 kinds of tonsils 1.Tonsilla palatina 2.Tonsilla lingualis 3.Tonsilla pharyngica TONSILLA

21 TONSILLA PALATINA  Location : between arcus glosso-palatinus and arcus pharyngo-palatinus  Stratified squamous nonkeratinazing epithelium  to make deep and branch dents called “crypte”  Content, usually one lymphonoduli layer  Has capsule  No vasa afferent

22 Tonsilla palatina

23 TONSILLA LINGUALIS  Location: at radix linguae  Stratified squamous non keratinizing epithelium  Crypte: shallow, little, and seldom have branches  Related with weber gland at tongue  Has no vasa afferent

24 Tonsila lingualis

25 TONSILLA PHARYNGICA  Location: back wall of nasopharynx  Pseudostratified ciliated columnar with goblet cells epithelium  Has no crypte  Has no vasa afferent

26 TONSILLA PHARYNGICA

27 The biggest lymphatic organ Covered by dense connective tissue capsule that forms the fold in parenchym spleen  trabeculae Has concave medial surface, hillus  in and out circulation blood vessels place, nerve and the exit through vasa efferent There isn’t vasa afferent SPLEEN

28 Makroskopis Consist of 1.Round shapes / long called white pulp (diameter mm) 2.Dark red area called red pulp

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30 Microscopis WHITE PULP  Dense lymphoid tissue  Forming veil surrounds arteria centralis  Consist of 2 parts 1.Splenic nodule 2.Peri-arterial lymphoid sheath RED PULP  Consist of sinusoid plait with branch and anastomose  Red pulp tissue between sinusoids is called billroth cord  contains macrophage, erythrocyte, thrombocyte and plasmocyte

31 SPLENIC NODULE (CORPUSCLE)  Consist of: Primary nodule Germinal center  Composed from small – medium lymphocyte cell from B-lymphocyte, monocyte cell and plasma cell

32 PALS Peri-arterial lymphoid sheath are densely populated with T-cells The form lengthen, because follows the path of centralis artery

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34 Marginal Zone The border between white pulp and red pulp Loose lymphoid tissue Sinusoid is smaller than red pulp The first connection place for blood cell with parenchyme tissue Consist of macrophage cell and B- lymphocyte

35 MZ

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37 CAPSULE AND TRABECULAE Consist of reticuler, collagen fibers and smooth muscle Surface covered by mesothelium Trabeculae contains many elastic fibers and inside of it, there are artery and vein trabecularis also lymph node

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39 Trabecularis arteri / vein

40 ARTERY PENICILLAR Consist of 3 components 1.Pulp artery  Quite long, has one smooth muslce layer and some layers lymphoid tissue 2.Sheathed artery  It’s capillary, but has a cover scheiweigger- seidel sheath that consists of reticuler fibers & reticullum cells  looks clear at cat / dog 3.Terminal artery  Capillary related to venous sinusoid or venule directly in red pulp

41 Sheated artery trabeculae

42 Pulp artery

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44 Lymphatic organ formed earliest (6 th week of pregnancy) and keep bigger till puberty, then going down ( aged involution) Location : mediastinum proximal, in front of large blood vessel Macroscopis: flat shape, grey and consist of two lobes THYMUS

45 Microscopis Each lobus covered by thin loose connective tissue capsule Has no vasa afferent Each lobulus is devided into : 1. cortex (dark) and 2. medulla (bright)

46 CORTEX  Looks darker  Constructed from : Reticuler cells Large lymphocyte (edge) Medium lymphocyte (center) Small lymphocyte (inside/near medulla) Macrophage  spreaded in cortex  it’s amount increases at cortex border and medulla There are mast cells in extralobuler

47 MEDULLA  Composed from: Reticullum cell small lymphocyte, called thymocyte, little amount, not in order shape, more cytoplasma Rare macrophage Little eosinophil Countain no plasma cell

48 Hassal’s Corpuscle oSize: 100 micron oComposed from flat reticulum cell oConcentris arrangement oHas ceratohyaline granules oHas filamen cytoplasma protusion oIts center will be hyaline degeneration / calsification

49 Function Forming T-lymphocyte Body immunity

50 Cortex

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