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The Immune and Lymphatic System By Renira Rugnath and Jeshanah Johnson.

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2 The Immune and Lymphatic System By Renira Rugnath and Jeshanah Johnson

3 Basics Homeostasis, or a "steady state," is a continual balancing act of the body systems to provide an internal environment that is comparable with life. The two liquid tissues of the body, the blood and lymph have separate but interrelated functions in maintaining this balance. They combine with a third system, the immune, to protect the body against pathogens that could threaten the organism's viability.

4 The blood is responsible for the following: Transportation of gases (oxygen O2) and carbon dioxide (CO2), chemical substances (hormones, nutrients, salts), and cells that defend the body. Regulation of the body's fluid and electrolyte balance, acid-base balance, and body temperature. Protection of the body from infection. Protection of the body from loss of blood by the action of clotting.



7 The Immune System The immune system, which is made up of special cells, proteins, tissues, and organs, defends people against germs and microorganisms every day. In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

8 The Lymphatic System The lymphatic system is a system of capillaries, vessels, nodes and other organs that transport a fluid called lymph from the tissues as it returns to the bloodstream. The lymphatic tissue of these organs filters and cleans the lymph of any debris, abnormal cells, or pathogens. The lymphatic system also transports fatty acids from the intestines to the circulatory system. One way system that flows toward the heart

9 In a way your lymph system works like the Nile River!

10 Lymphedema A condition caused by the excess of fluid in the tissues and the blockage in the lymphatic vessels Elephantiasis An infection in the vessels that causes a thickening of the skin and enlargement of the tissues.

11 Immune System vs. Lymphatic System Protects the body against  Bacteria  Viruses  Fungi  Toxins  Parasites  Cancer Works with the Immune System to remove disease- causing agents. Organs  Thymus  Spleen  Lymph Nodes What’s the Difference?

12 Key Characteristics 1. Recognizes specific foreign molecules. 2. Destroys key pathogens 3. Key cells – lymphocytes 4. Also includes lymphoid tissue and lymphoid organs Immune System

13 Anatomy The structures in the system 1.What they look like 2.Where they are 3.What they do

14 Bone Marrow Red bone marrow is a highly vascular tissue found in the spaces between trabeculae of spongy bone. It is mostly found in the ends of long bones and in the flat bones of the body. Red bone marrow is a hematopoietic tissue containing many stem cells that produce blood cells. All of the leukocytes, or white blood cells, of the immune system are produced by red bone marrow.

15 Leukocytes Leukocytes can be further broken down into 2 groups based upon the type of stem cells that produces them: myeloid stem cells and lymphoid stem cells.

16 Myeloid Stem Cells Lymphoid Stem Cells Myeloid stem cells produce monocytes and the granular leukocytes— eosinophils, basophils, and neutrophils. Lymphoid stem cells produce T lymphocytes and B lymphocytes

17 Monocytes are agranular leukocytes that can form 2 types of cells: macrophages and dendritic cells Macrophages Monocytes respond slowly to infection and once present at the site of infection, develop into macrophages. Macrophages are phagocytes able to consume pathogens, destroyed cells, and debris by phagocytosis. As such, they have a role in both preventing infection as well as cleaning up the aftermath of an infection. Dendritic cells Monocytes also develop into dendritic cells in healthy tissues of the skin and mucous membranes. Dendritic cells are responsible for the detection of pathogenic antigens which are used to activate T cells and B cells. Monocytes

18 Lymphoid stem cells produce T lymphocytes and B lymphocytes. T lymphocytes. T lymphocytes, also commonly known as T cells, are cells involved in fighting specific pathogens in the body. T cells may act as helpers of other immune cells or attack pathogens directly. After an infection, memory T cells persist in the body to provide a faster reaction to subsequent infection by pathogens expressing the same antigen. B lymphocytes. B lymphocytes, also commonly known as B cells, are also cells involved in fighting specific pathogens in the body. Once B cells have been activated by contact with a pathogen, they form plasma cells that produce antibodies. Lymphocytes

19 Natural killer cells. Natural killer cells, also known as NK cells, are lymphocytes that are able to respond to a wide range of pathogens and cancerous cells. NK cells travel within the blood and are found in the lymph nodes, spleen, and red bone marrow where they fight most types of infection. Antibodies then neutralize the pathogens until other immune cells can destroy them. After an infection, memory B cells persist in the body to quickly produce antibodies to subsequent infection by pathogens expressing the same antigen.

20 The granular leukocytes produce eosinophils, basophils, and neutrophils Eosinophils. Eosinophils are granular leukocytes that reduce allergic inflammation and help the body fight off parasites. Basophils. Basophils are granular leukocytes that trigger inflammation by releasing the chemicals heparin and histamine. Basophils are active in producing inflammation during allergic reactions and parasitic infections. Neutrophils. Neutrophils are granular leukocytes that act as the first responders to the site of an infection. Neutrophils use chemo taxis to detect chemicals produced by infectious agents and quickly move to the site of infection. Once there, neutrophils ingest the pathogens via phagocytosis and release chemicals to trap and kill the pathogens. Granular Leukocytes

21 Lymph Think of lymph as a river. It carries the pathogens through the lymphatic vessels and through the lymph nodes for filtering Clear, watery fluid Found between cells and throughout the body Created when blood plasma leaks out of the capillaries You have about five and a half gallons of lymph fluid inside of you!


23 Lymph Capillaries/Vessels Thin Permeable walls. Made of a single layer of endothelial cells. (this is why it is so easy for the lymph to transfer into the bloodstream) Only open on one end (unlike the digestive system) The closed end happens because of the overlapping of endothelial cells. It creates a flap that makes it easy for fluid to pass through the capillary. Like the digestive system, the capillaries have flaps to keep the lymph from flowing in the wrong direction. Carries harmful substances through the lymph to be expelled.

24 Pulse Activity!!! How many pulse points to you know!?

25 There Are 9!!! Temporal- temples Carotid-neck Apical-heart/chest Brachial-elbow Radial-wrist Femoral-groin Popliteal-knee Dorsalis Pedis- top of foot Posterior Tibial-behind ankle

26 Lymph Nodes Lymph nodes are small, kidney-shaped organs of the lymphatic system. There are several hundred lymph nodes found mostly throughout the thorax and abdomen of the body with the highest concentrations in the axillary (armpit) and inguinal (groin) regions. The outside of each lymph node is made of a dense fibrous connective tissue capsule. Inside the capsule, the lymph node is filled with reticular tissue containing many lymphocytes and macrophages. Range from being microscopic to the size of a marble.

27 The lymph nodes function as filters of lymph that enters from several afferent lymph vessels. The reticular fibers of the lymph node act as a net to catch any debris or cells that are present in the lymph. Macrophages and lymphocytes attack and kill any microbes caught in the reticular fibers. Efferent lymph vessels then carry the filtered lymph out of the lymph node and towards the lymphatic ducts.

28 Lymph Node Pictures

29 Can Anyone Guess How Many Lymph nodes you have in your entire body???

30 An estimated total of 100,000!

31 Mind Blowing Right?!

32 Lymph Ducts There are two main types: Right Lymphatic Duct and Thoracic Duct Lymph is delivered to one of two large ducts Right lymphatic duct drains lymph from the right upper arm and the right side of the head and thorax Thoracic duct receives lymph from the rest of the body Where all of the lymphatic vessels come together

33 Lymph Trunks Are formed by many lymphatic vessels Drain Lymph into the two lymph ducts Four types of lymph trunks: Jugular Lymph Trunks Subclavian Lymph Trunks Bronchomediastinal lymph trunks Lumbar lymph trunks Intestinal lymph trunk

34 Where are they located?

35 Lymphatic Nodules A densely packed area of lymph cells An area where lymphocyte is activated. Can appear anywhere in the body. Found within the lymph nodes Mainly in… Tonsils Spleen Thymus


37 Tonsils There are 5 tonsils in the body—2 lingual, 2 palatine, and 1 pharyngeal. The lingual tonsils are located at the posterior root of the tongue near the pharynx. The palatine tonsils are in the posterior region of the mouth near the pharynx. The pharyngeal pharynx, also known as the adenoid, is found in the nasopharynx at the posterior end of the nasal cavity. The tonsils contain many T and B cells to protect the body from inhaled or ingested substances. The tonsils often become inflamed in response to an infection.

38 Most people have them removed because they are swollen, but they are usually swollen because they are working overtime trying to produce antibodies to keep your throat healthy. Tonsils protect our throats from the plaque that we swallow. When the plaque reaches the stomach, acids usually get rid of the bacteria.

39 Tonsil Pictures

40 Adenoids The pharyngeal pharynx, also known as the adenoid, is found in the nasopharynx at the posterior end of the nasal cavity. Perform the same function and housed in the same location as the tonsils.

41 What is the dirtiest and most infectious place in the human body???


43 Thymus The thymus is a small, triangular organ found just posterior to the sternum and anterior to the heart. The thymus is mostly made of glandular epithelium and hematopoietic connective tissues. The thymus produces and trains T cells during fetal development and childhood. T cells formed in the thymus and red bone marrow mature, develop, and reproduce in the thymus throughout childhood.

44 The vast majority of T cells do not survive their training in the thymus and are destroyed by macrophages. The surviving T cells spread throughout the body to the other lymphatic tissues to fight infections. By the time a person reaches puberty, the immune system is mature and the role of the thymus is diminished. After puberty, the inactive thymus is slowly replaced by adipose tissue.

45 Thymus Pictures

46 Spleen The spleen is a flattened, oval-shaped organ located in the upper left quadrant of the abdomen lateral to the stomach. The spleen is made up of a dense fibrous connective tissue capsule filled with regions known as red and white pulp. Red pulp, which makes up most of the spleen’s mass, is so named because it contains many sinuses that filter the blood. Red pulp contains reticular tissues whose fibers filter worn out or damaged red blood cells from the blood.

47 Macrophages in the red pulp digest and recycle the hemoglobin of the captured red blood cells. The red pulp also stores many platelets to be released in response to blood loss. White pulp is found within the red pulp surrounding the arterioles of the spleen. It is made of lymphatic tissue and contains many T cells, B cells, and macrophages to fight off infections.

48 Spleen Pictures

49 Peyer’s Patch Peyer’s patches are small masses of lymphatic tissue found in the ileum of the small intestine. Peyer’s patches contain T and B cells that monitor the contents of the intestinal lumen for pathogens. Once the antigens of a pathogen are detected, the T and B cells spread and prepare the body to fight a possible infection.

50 Physiology The function of each systemThe function of each system

51 Lymph Circulation One of the primary functions of the lymphatic system is the movement of interstitial fluid from the tissues to the circulatory system. Like the veins of the circulatory system, lymphatic capillaries and vessels move lymph with very little pressure to help with circulation. To help move lymph towards the lymphatic ducts, there is a series of many one-way check valves found throughout the lymphatic vessels. These check valves allow lymph to move toward the lymphatic ducts and close when lymph attempts to flow away from the ducts.

52 In the limbs, skeletal muscle contraction squeezes the walls of lymphatic vessels to push lymph through the valves and towards the thorax. In the trunk, the diaphragm pushes down into the abdomen during inhalation. This increased abdominal pressure pushes lymph into the less pressurized thorax. The pressure gradient reverses during exhalation, but the check valves prevent lymph from being pushed backwards.

53 Transport of Fatty Acids Another major function of the lymphatic system is the transportation of fatty acids from the digestive system. The digestive system breaks large macromolecules of carbohydrates, proteins, and lipids into smaller nutrients that can be absorbed through the villi of the intestinal wall. Most of these nutrients are absorbed directly into the bloodstream, but most fatty acids, the building blocks of fats, are absorbed through the lymphatic system.

54 In the villi of the small intestine are lymphatic capillaries called lacteals. Lacteals are able to absorb fatty acids from the intestinal epithelium and transport them along with lymph. The fatty acids turn the lymph into a white, milky substance called Chyme. Chyme is transported through lymphatic vessels to the thoracic duct where it enters the bloodstream and travels to the liver to be metabolized.

55 Types of Immunity The body employs many different types of immunity to protect itself from infection from a seemingly endless supply of pathogens. These defenses may be external and prevent pathogens from entering the body. Conversely, internal defenses fight pathogens that have already entered the body. Among the internal defenses, some are specific to only one pathogen or may be innate and defend against many pathogens. Some of these specific defenses can be acquired to preemptively prevent an infection before a pathogen enters the body.

56 Innate Immunity The body has many innate ways to defend itself against a broad spectrum of pathogens. These defenses may be external or internal defenses. The internal defenses include:  Fever  Inflammation  natural killer cells  phagocytes.  We will discuss in depth later on…

57 External Defenses The coverings and linings of the body constantly prevent infections before they begin by barring pathogens from entering the body. Epidermal cells are constantly growing, dying, and shedding to provide a renewed physical barrier to pathogens. Secretions like sebum, cerumen, mucus, tears, and saliva are used to trap, move, and sometimes even kill bacteria that settle on or in the body. Stomach acid acts as a chemical barrier to kill microbes found on food entering the body. Urine and acidic vaginal secretions also help to kill and remove pathogens that attempt to enter the body. Finally, the flora of naturally occurring beneficial bacteria that live on and in our bodies provide a layer of protection from harmful microbes that would seek to colonize our bodies for themselves.

58 Internal Defenses 1. Fever - In response to an infection, the body may start a fever by raising its internal temperature out of its normal homeostatic range. Fevers help to speed up the body’s response system to an infection while at the same time slowing the reproduction of the pathogen.

59 2. Inflammation - The body may also start an inflammation in a region of the body to stop the spread of the infection. Inflammations are the result of a localized vasodilation that allows extra blood to flow into the infected region. The extra blood flow speeds the arrival of leukocytes to fight the infection. The enlarged blood vessel allows fluid and cells to leak out of the blood vessel to cause swelling and the movement of leukocytes into the tissue to fight the infection.

60 3. Natural Killer Cells - Natural killer (NK) cells are special lymphocytes that are able to recognize and kill virus-infected cells and tumor cells. NK cells check the surface markers on the surface of the body’s cells, looking for cells that are lacking the correct number of markers due to disease. The NK cells then kill these cells before they can spread infection or cancer. Discuss in detail later on…

61 4. Phagocytes - The term phagocyte means “eating cell” and refers to a group of cell types including neutrophils and macrophages. A phagocyte engulfs pathogens with its cell membrane before using digestive enzymes to kill and dissolve the cell into its chemical parts. Phagocytes are able to recognize and consume many different types of cells, including dead or damaged body cells..

62 5. Cell-mediated Specific Immunity - When a pathogen infects the body, it often encounters macrophages and dendritic cells of the innate immune system. These cells can become antigen-presenting cells (APCs) by consuming and processing pathogenic antigens. The APCs travel into the lymphatic system carrying these antigens to be presented to the T cells and B cells of the specific immune system.

63 Inactive T cells are found in lymphatic tissue awaiting infection by a pathogen. Certain T cells have antigen receptors that recognize the pathogen but do not reproduce until they are triggered by an APC. The activated T cell begins reproducing very quickly to form an army of active T cells that spread through the body and fight the pathogen. Cytotoxic T cells directly attach to and kill pathogens and virus- infected cells using powerful toxins. Helper T cells assist in the immune response by stimulating the response of B cells and macrophages.

64 After an infection has been fought off, memory T cells remain in the lymphatic tissue waiting for a new infection by cells presenting the same antigen. The response by memory T cells to the antigen is much faster than that of the inactive T cells that fought the first infection. The increase in T cell reaction speed leads to immunity—the reintroduction of the same pathogen is fought off so quickly that there are few or no symptoms. This immunity may last for years or even an entire lifetime.

65 6. Antibody-mediated Specific Immunity. During an infection, the APCs that travel to the lymphatic system to stimulate T cells also stimulate B cells. B cells are lymphocytes that are found in lymphatic tissues of the body that produce antibodies to fight pathogens (instead of traveling through the body themselves). Once a B cell has been contacted by an APC, it processes the antigen to produce an MHC - antigen complex. Helper T cells present in the lymphatic system bind to the MHC -antigen complex to stimulate the B cell to become active. The active B cell begins to reproduce and produce 2 types of cells: plasma cells and memory B cells.

66 Plasma and Memory B Cells Plasma cells become antibody factories producing thousands of antibodies. Memory B cells reside in the lymphatic system where they help to provide immunity by preparing for later infection by the same antigen-presenting pathogen. Antibodies are proteins that are specific to and bind to a particular antigen on a cell or virus. Once antibodies have latched on to a cell or virus, they make it harder for their target to move, reproduce, and infect cells. Antibodies also make it easier and more appealing for phagocytes to consume the pathogen.

67 7. Acquired Immunity - Under most circumstances, immunity is developed throughout a lifetime by the accumulation of memory T and B cells after an infection. There are a few ways that immunity can be acquired without exposure to a pathogen. Immunization is the process of introducing antigens from a virus or bacterium to the body so that memory T and B cells are produced to prevent an actual infection.

68 Most immunizations involve the injection of bacteria or viruses that have been inactivated or weakened. Newborn infants can also acquire some temporary immunity from infection thanks to antibodies that are passed on from their mother. Some antibodies are able to cross the placenta from the mother’s blood and enter the infant’s bloodstream. Other antibodies are passed through breast milk to protect the infant

69 Diseases of the Immune System Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer. Immunodeficiency occurs when the immune system is not as strong as normal, resulting in recurring and life- threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or through the use of immunosuppressive medication.

70 On the opposite end of the spectrum, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign bodies. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1 and systemic lupus erythematous. Asthma and allergies also involve the immune system. A normally harmless material such as grass pollen, food particles, mold or pet dander is mistaken for a severe threat and attacked. While symptoms of immune diseases vary, fever and fatigue are common signs that the immune system is not functioning properly

71 The only other system the immune system actually works with is the circulatory system. You could say this because the main mode of transport for immune cells are the blood vessels. The circulatory system allows immune cells to travel throughout the body and survey for infection. While the immune system isn't involved in any other systems, its effects can appear in others in various diseases and infections.

72 Most infections involve immune reactions that occur in the tissue of the digestive tract and there are autoimmune diseases (disorders where the immune system attacks the body instead of a pathogen) for almost any organ you can think of. I can give you some examples: Nervous system - Multiple sclerosis - the immune system attacks the myelin sheath of neurons leading to impaired ability to conduct nerve impulses resulting in increasing paralysis and dis-coordination Skeletal system - Rheumatoid arthritis - the immune system attacks the synovial membranes that lubricate joints causing inflammation at the joints

73 Muscular system - Myasthenia gravis - the immune system attacks the synapse between motor neurons and muscles impairing the ability to tell muscles when or when not to contract resulting in muscle weakness and spasms Endocrine system - type I diabetes - immune system attacks the beta cells in the pancreas that produce insulin resulting in high blood glucose due to insulin deficiency Digestive system - Celiac's Disease - immune system attacks gluten in the intestines leading to an over reactive response that damages nearby tissue

74 Fun Facts Antibacterial products may actually weaken the immune system Intense endurance exercice disrupts immune system functions.

75 Laughter is the best medicine! Laughter improves resistance to disease by: Decreasing stress hormones Increasing immune cells and infection-fighting antibodies Even just anticipating a funny effect can positively affect your immune system ! The immune system is strengthened only one month after quitting smoking Dieting weakens the immune system

76 Do You Know Your Defense? Time for an activity! Test your knowledge on the immune and lymphatic system. 1.Divide into two groups 2.Elect a speaker 3.Have fun

77 15510 Structure Function Difference Speaker

78 Structure What are the primary organs of the immune and lymphatic systems? Show Answer 5

79 1.Tonsil and Adenoids 2.Thymus 3.Lymph Nodes 4.Appendix 5.Bone Marrow 6.Lymphatic Vessels 7.Spleen Back to Board 5

80 Structure What is this a diagram of? Show Answer 10

81 Lymph Nodes Back to Board 10

82 Structure What is this a diagram of? Show Answer 15

83 Thymus Back to Board 15

84 Structure __________ is the largest lymphatic vessel that empties into left Subclavian Vein Show Answer 20

85 Thoracic Duct Back to Board 20

86 Structure What is this? Show Answer 25

87 Spleen Back to Board 25 Double or Nothing?

88 The Spleen houses what types of cells? Hint: They are one of the main defense against antigens in blood 50 Back to Board

89 One of the purposes of the immune system is to prevent ________ from entering the body. Show Answer 5

90 Antigens Back to Board 5

91 The major immune function of the B-cells is to _________________ Show Answer 10

92 Produce Antibodies Back to Board 10

93 Vaccinations for diphtheria, measles, mumps, pertussis, etc. is known as: Show Answer 15

94 artificial active immunity Back to Board 15

95 Discuss at least one thing that happens in each of the four stages of immune system action. Stage 1 Stage 2 Stage 3 Stage 4 Show Answer 20

96 Stage 1: virus invades body, Helper T cells activates Stage 2: Helper T cells multiply and stimulate B cells that start producing antibodies Stage 3: Complement proteins break cell walls and antibodies attack the virus Stage 4: Suppressor T cells stop immune process and B cells remain ready to fight Back to Board 20

97 The major body defense represented by the skin, tears, and mucous membranes is the _________________ system. Show Answer 25

98 Mechanical Back to Board 25

99 Immune vs. Lymphatic System Main Difference: ___________ diseases ___________ defense Show Answer 5

100 Prevents Active Back to Board 5

101 The Immune System is a _____________________ system The Lymphatic System is a ____________________ system Show Answer 10

102 Functional Structural Back to Board 10

103 Name one thing that both the lymphatic and immune system share. Show Answer 15

104 Anatomical structures Back to Board 15

105 The Immune system _________ pathogens while the Lymphatic system ________ pathogens. Show Answer 20

106 Prevents Remove Back to Board 20

107 The lymphatic system also transports _________ from the intestines to the circulatory system. Show Answer 25

108 Fatty acids Back to Board 25

109 J enny, a 6-year-old child who has been raised in a germ-free environment from birth, is a victim of one of the most severe examples of an abnormal immune system. Jenny also suffers from cancer caused by the Epstein Barr virus. Relative to this case: Show Question BP

110 ( a) What is the usual fate of children with Jenny's condition and similar circumstances if no treatment is attempted? (b) Why is Jenny's brother chose as the hematopoietic stem cell donor? (c) Why is her physician planning to use the umbilical cord blood as a source of stem cells for transplant if her brother's stem cells fail (what are the hoped for results)? (d) attempt to explain Jenny's cancer. (e) What similarities and dissimilarities exists between Jenny's illness and aids? BP Show Answer

111 a. Jenny has severe combined immunodeficiency disease (SCID), in which T cells and B cells fail to develop. At best there are only a few detectable lymphocytes. If left untreated, this condition is fatal. BP B. And C.

112 b. Jenny's brother has the closest antigenic match, as both children are from the same parents. c. Bone marrow transplant using umbilical cord stem cells is the next best chance for survival. It is hoped that by replacing marrow stem cells, the populations of T cells and B cells would approach normal. D BP

113 d. Epstein-Barr virus is the etiologic agent of infectious mononucleosis, usually a self-limiting problem with recovery in a few weeks. Rarely, the virus causes the formation of cancerous B cells— Burkitt's lymphoma. E BP

114 e. SCID is a congenital defect in which there is a lack of the common stem cell that develops into T cells and B cells. AIDS is the result of an infectious process by a virus that selectively incapacitates the CD4 (helper) T cells. Both result in a severe immunodeficiency that leaves the individual open to opportunistic pathogens and body cells that have lost normal control functions (cancerous). Back to Board BP

115 Citation 1.Jeff Ertzberger. Big Board Facts August 22, 2.National Institute of Allergy and Infectious Diseases. The Immune System August 22, Bozeman Science. The Immune System August 23, M.J. Farabee. Lymphatic System and Immunity. August 23, Drinker, Cecil K. The Lymphatic System 404th ser (1945): Print. Annual Reviews. Web of Science. Web. 28 Aug Booth, Whicker, Wyman, Pugh, and Thompson. "Google." Google. The McGraw-Hill Company, Web. 28 Aug w- /589006/Chapter_32_The_Lymphatic_and_Immun e_System.ppt+lymphatic+system+powerpoint&cd=6&hl=en&ct=clnk&gl=us

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