1. Cancer diagnosis GPs view of diagnosis and treatment Bruce Arroll Dept of General Practice and Primary Health care School of Population Health

2. Disclaimer Asked to talk about experience Some in audience may have had worse health experiences AML is rare and there may be some interest in the treatment aspects

3. Diagnosis Pharyngeal pain 1 month Difficulty in swallowing Practice meeting in public holidays Partners think they can see something and so can I Email ENT classmate offers to check Referred to public system –CT scan normal apart from lump on tongue

4. Two biopsies GA for biopsy Preop/post op very friendly to everyone –no special doctor treatment ENT surgeon going overseas so phone call to say possible lymphoma 10 minutes later at Uni farewell and colleague asks how biopsy went : decide on everyone knowing or no-one knowing Tell people –the word is out so pass it on

5. Diagnosis Needed bone marrow biopsy – painful Needed lumbar puncture not painful –Colleague advised me to enjoy the pain and not resist Registrar says I have acute myeloid leukemia on my tongue but not in the bone marrow- no other cases in the literature Gap to getting treatment knowledge – hematologists have a conference

6. Toxic uncertainty Will I be dead in a week or live to 90 Appreciation of what patients go thru Relief to know that will only get chemotherapy and not radiotherapy (teeth issues) Although bone marrow clear will get ¾ rounds of chemotherapy Inspired by a patient who wanted chemotherapy for her bowel cancer Adopted a “bring on the chemotherapy”

8. Getting the hardware Insertion of a Groshong line in to chest. Goes in to the superior vena cava Done by radiology in small operating room Some fentanyl and meditation and enjoy the pain Sits in chest indefinitely –Two ports –Can infuse chemotherapy –Can take blood –Can give blood

10. Removing the hardware Klebsiella infection on Groshong Removal like pulling a weed from the garden –Not painful just alarming

11. Single room or 4 patient room Given choice most would take single room For cyclical treatment advantage of 4 patient room –Education –company For cyclical treatment advantage of 4 patient room First impression –We are all up the same creek –instant camaraderie

13. Starting chemotherapy Daunorubicin (red) and cytarabine Nurses (? Informal meeting) decide to treat me a normal patient rather than a doctor Suited me as I was pretty clueless about what was happening Except when inserting IV lines later saying doing this to a doctor made them nervous Told I would need blood and platelet tranfusions and get infections Wont happen to me!!!!!- 10 of both

14. Chemotherapy Red chemo causes red urine Blue chemo causes blue urine No vomiting –most amazing –Ondansetron Historically patients would vomit the whole time Took anti-nauseants happily as too afraid of nausea

16. Aim of chemotherapy “Wipe out” the bone marrow Kept alive with transfusions and antibiotics When bone marrow restarts they “wipe it out” again

17. First infection A few days after completing first treatment admitted with ‘infection” and neutropenia

18. Infection versus septicemia Admitted for infection –Main risk is own flora not that of others Colleagues “ingrown toenail versus septicaemia” Neutropenia and fever Don’t usually grow bacteria Klebsiella called bacteremia Mortality for treatment 5% –For BA 1%

20. Platelets What level safe to go to gym 50 ???!!! BA would consider rapid referral of someone with platelets of 50. Can do eye surgery at about 80 4 th standard deviation world

22. Allergic reaction 4 th cephalosporin and gentamicin Maculo papular rash on trunk –non itchy Decided later to try gentamicin I was amazed that they still use it

24. Other effects Hair loss Most people bald on ward

29. Cancer out patients Got to like going there –contrast to ward I was not sick “major stress” – 3hrly temperatures “Forced retirement” – social contact –More understanding of patients

31. Sign that is was over Next slide

33. Next event