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The Oxidative Steps of the Pentose Phosphate Pathway Figure 22.23 The glucose-6-phosphate dehydrogenase reaction is the committed step in the pentose phosphate.

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Presentation on theme: "The Oxidative Steps of the Pentose Phosphate Pathway Figure 22.23 The glucose-6-phosphate dehydrogenase reaction is the committed step in the pentose phosphate."— Presentation transcript:

1 The Oxidative Steps of the Pentose Phosphate Pathway Figure The glucose-6-phosphate dehydrogenase reaction is the committed step in the pentose phosphate pathway. Mistake in book NOT reversible

2 The three most energy consuming Reactions of glycolysis are replaced in gluconeogenesis, NOT just the ones in Glycolysis that consume ATP as stated in lecture. A way to remember which ones differ First two and last reaction differ. The ones here without double arrows.

3 Glycolysis substrates Good Gracious Father Frank Did Go By Picking Pumpkins (to) Prepare Pie. Glucose Glucose 6-Phosphate Fructose 6-Phosphate Fructose 1,6 Bis-Phosphate Dihydroxyacetone Phosphate Glyceraldehyde 3-Phosphate 1,3- Bisphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate Phosphoenolpyruvate Pyruvate

4 Glycolysis enzymes "High Profile People Act Too Glamorous, Picture Posing Every Place": Hexokinase Phosphoglucose isomerase Phosphofructokinase (PFK) Aldase A Triose phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase Phosphoglycerate mutase Enolase Pyruvate kinase

5 Citric acid cycle compounds "Oh Citric Acid Is Of (course) A SiLly STupid Funny Molecule": Oxaloacetate Citrate Aconitate Isocitrate Oxalosuccinate Alpha-ketoglutarate SuccinyL-CoA SuccinaTe Fumarate Malate · SilLy and sTupid used to differentiate succinyL and succinaTe

6 Deficient enzyme in glycogen storage disorder A-B Anderson-(glycogen)Branching enzyme C-D Cori's-(glycogen)Debranching enzyme M-M Mcardle's-Muscle glycogen phosphorylase H-H Her's-Hepatic glycogen phosphorylase

7 G6PD: oxidant drugs inducing hemolytic anemia AAA: Antibiotic (eg: sufamethoxazole) Antimalarial (eg: primaquine) Antipyretics (eg: acetanilid, but not aspirin or acetaminophen)

8 Carbon monoxide: electron transport chain target "CO blocks CO": Carbon monoxide (CO) blocks Cytochrome Oxidase (CO) Show Details / Rate It ---Anonymous Contributor Electron transport chain: Rotenone's site of action Rotenone is a site specific inhibitor of complex one. Metabolism sites "Use both arms to HUG": Heme synthesis Urea cycle Gluconeogenesis · These reactions occur in both cytoplasm and mitochondria.

9 Glucagon function "Mr. Gluca has Gone to the cAMP to bring out some Glucose": · Glucagon elevates glucose by cAMP mechanism.


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