Presentation on theme: "The Oxidative Steps of the Pentose Phosphate Pathway"— Presentation transcript:
1 The Oxidative Steps of the Pentose Phosphate Pathway Mistake in bookNOT reversibleFigure The glucose-6-phosphate dehydrogenase reaction is the committed step in the pentose phosphate pathway.
2 The three most energy consuming Reactions of glycolysis are replaced ingluconeogenesis, NOT just the ones inGlycolysis that consume ATP as statedin lecture.A way to remember which ones differFirst two and last reaction differ.The ones here without double arrows.
3 Glycolysis substrates Good Gracious Father Frank Did Go By Picking Pumpkins (to) Prepare Pie. Glucose Glucose 6-Phosphate Fructose 6-Phosphate Fructose 1,6 Bis-Phosphate Dihydroxyacetone Phosphate Glyceraldehyde 3-Phosphate 1,3- Bisphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate Phosphoenolpyruvate Pyruvate
4 Glycolysis enzymes"High Profile People Act Too Glamorous, Picture Posing Every Place": Hexokinase Phosphoglucose isomerase Phosphofructokinase (PFK) Aldase A Triose phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase Phosphoglycerate mutase Enolase Pyruvate kinase
5 Citric acid cycle compounds "Oh Citric Acid Is Of (course) A SiLly STupid Funny Molecule": Oxaloacetate Citrate Aconitate Isocitrate Oxalosuccinate Alpha-ketoglutarate SuccinyL-CoA SuccinaTe Fumarate Malate · SilLy and sTupid used to differentiate succinyL and succinaTe
7 G6PD: oxidant drugs inducing hemolytic anemia AAA: Antibiotic (eg: sufamethoxazole) Antimalarial (eg: primaquine) Antipyretics (eg: acetanilid, but not aspirin or acetaminophen)
8 Carbon monoxide: electron transport chain target "CO blocks CO": Carbon monoxide (CO) blocks Cytochrome Oxidase (CO) Show Details / Rate It ---Anonymous Contributor Electron transport chain: Rotenone's site of actionRotenone is a site specific inhibitor of complex one.Metabolism sites"Use both arms to HUG": Heme synthesis Urea cycle Gluconeogenesis · These reactions occur in both cytoplasm and mitochondria.
9 Glucagon function"Mr. Gluca has Gone to the cAMP to bring out some Glucose": · Glucagon elevates glucose by cAMP mechanism.